{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:50:10Z","timestamp":1793253010338,"version":"4.5.0"},"reference-count":27,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Candioli S.r.l"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet. Sci.","Veterinary Sciences"],"abstract":"<jats:p>(1) Background: Acute diarrhea is a frequent clinical manifestation in dogs, often involving dysbiosis and mucosal barrier impairment. This study evaluated the efficacy of Florentero Complex\u00ae (Candioli S.r.l.), a multi-targeted dietary supplement combining probiotics, prebiotics, and antioxidant components, in supporting the recovery of dogs with acute diarrhea. (2) Methods: In a randomized, controlled trial, 28 client-owned dogs presenting with acute diarrhea for 3\u20134 days were assigned to either a Treated Group (TRT: standard commercial diet plus supplement) or a Control Group (CTR: standard commercial diet alone) for 7 days. Daily defecation frequency (nDEF), fecal score (FS), and inflammatory markers (fecal cytology and C-reactive protein) were monitored throughout the study. (3) Results: Both groups showed a reduction in nDEF over time, with no significant difference observed between groups. However, a significant intergroup difference in FS was observed, with the supplemented dogs showing a faster and more pronounced improvement in stool consistency than the CTR. Fecal cytology and serum CRP levels also showed a trend toward reduced inflammation in the TRT group. (4) Conclusions: Florentero Complex\u00ae appears to provide nutritional support that improves clinical signs and stool quality beyond standard dietary management alone.<\/jats:p>","DOI":"10.3390\/vetsci13080837","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:57:53Z","timestamp":1787230673000},"page":"837","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Dietary Supplement Supporting the Resolution of Acute Diarrhea in Dogs"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4703-7559","authenticated-orcid":false,"given":"Francesca","family":"Perondi","sequence":"first","affiliation":[{"name":"Department of Veterinary Science, University of Pisa, 56122 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4062-8006","authenticated-orcid":false,"given":"Natascia","family":"Bruni","sequence":"additional","affiliation":[{"name":"Candioli S.r.l., 10092 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Adami","sequence":"additional","affiliation":[{"name":"Candioli S.r.l., 10092 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4969-5136","authenticated-orcid":false,"given":"Giorgia","family":"Meineri","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Turin, 10095 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8405-226X","authenticated-orcid":false,"given":"Lucia","family":"Zema","sequence":"additional","affiliation":[{"name":"PhormulaMI Lab, Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-3314","authenticated-orcid":false,"given":"Alice","family":"Melocchi","sequence":"additional","affiliation":[{"name":"PhormulaMI Lab, Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0247-6670","authenticated-orcid":false,"given":"Elisa","family":"Martello","sequence":"additional","affiliation":[{"name":"Centre for Evidence Based Healthcare, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tvjl.2016.04.011","article-title":"Diagnosis and interpretation of intestinal dysbiosis in dogs and cats","volume":"215","author":"Suchodolski","year":"2016","journal-title":"Vet. 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