{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:28:14Z","timestamp":1787632094522,"version":"build-2736575974"},"reference-count":174,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32502991"],"award-info":[{"award-number":["32502991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32072809"],"award-info":[{"award-number":["32072809"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["32502991"],"award-info":[{"award-number":["32502991"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"award":["32072809"],"award-info":[{"award-number":["32072809"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Jiangsu Province Outstanding Postdoctoral Research Project","award":["2025ZB572"],"award-info":[{"award-number":["2025ZB572"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet. Sci.","Veterinary Sciences"],"abstract":"<jats:p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most prevalent chronic liver diseases worldwide, involving multiple pathological mechanisms such as lipid metabolism disorders, oxidative stress, chronic inflammation, insulin resistance, and dysregulation of the gut\u2013liver axis. Currently, there remains a lack of effective and long-term safe therapeutic strategies for MASLD, necessitating the development of novel interventions. Plant-derived exosome-like nanovesicles (PELNs) represent naturally secreted nanoscale vesicles derived from plant cells. Their advantages, including extensive availability, high biocompatibility, low immune activation, remarkable stability, and convenient oral administration, make them attractive platforms for therapeutic delivery. PELNs can not only encapsulate natural bioactive compounds such as polyphenols, alkaloids, terpenoids, and polysaccharides but also serve as drug delivery vehicles to achieve liver-targeted transport and synergistic therapy. Current evidence for PELNs in MASLD is predominantly preclinical. In vitro studies have provided mechanistic insights into their effects on lipid metabolism, oxidative stress, inflammatory signaling, and hepatocellular injury, whereas animal studies have demonstrated improvements in hepatic steatosis and related metabolic abnormalities for selected PELNs. A smaller number of studies have investigated tissue distribution, oral uptake, or preliminary biosafety. However, systematic pharmacokinetic, long-term toxicological, and target-species clinical evidence remains insufficient. Accordingly, the therapeutic effects discussed in this review should be interpreted primarily as preclinical findings, and the applicability of PELNs in veterinary practice remains to be established.<\/jats:p>","DOI":"10.3390\/vetsci13090851","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:20:43Z","timestamp":1787577643000},"page":"851","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plant-Derived Exosome-like Nanovesicles for Metabolic Dysfunction-Associated Steatotic Liver Disease"],"prefix":"10.3390","volume":"13","author":[{"given":"Tinghong","family":"Kuang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaning","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1042\/CS20220572","article-title":"Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): Functional analysis of lipid metabolism pathways","volume":"136","author":"Badmus","year":"2022","journal-title":"Clin. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Nassir, F. (2022). NAFLD: Mechanisms, Treatments, and Biomarkers. Biomolecules, 12.","DOI":"10.3390\/biom12060824"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Pouwels, S., Sakran, N., Graham, Y., Leal, A., Pintar, T., Yang, W., Kassir, R., Singhal, R., Mahawar, K., and Ramnarain, D. (2022). Non-alcoholic fatty liver disease (NAFLD): A review of pathophysiology, clinical management and effects of weight loss. BMC Endocr. Disord., 22.","DOI":"10.1186\/s12902-022-00980-1"},{"key":"ref_4","first-page":"251","article-title":"Clinical applications and challenges in the field of extracellular vesicles","volume":"35","author":"Nieuwland","year":"2023","journal-title":"Med. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.7150\/thno.75899","article-title":"Multiplexed strategies toward clinical translation of extracellular vesicles","volume":"12","author":"Song","year":"2022","journal-title":"Theranostics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jconrel.2023.11.057","article-title":"Extracellular vesicles and their engineering strategies, delivery systems, and biomedical applications","volume":"365","author":"Yang","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Di Bella, M.A. (2022). Overview and Update on Extracellular Vesicles: Considerations on Exosomes and Their Application in Modern Medicine. Biology, 11.","DOI":"10.3390\/biology11060804"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Nowak, M., G\u00f3rczy\u0144ska, J., Ko\u0142odzi\u0144ska, K., Rubin, J., and Choroma\u0144ska, A. (2023). Extracellular Vesicles as Drug Transporters. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241210267"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Liu, Z., Yin, R., and Tian, J. (2025). Extracellular vesicles: Mechanisms and prospects in type 2 diabetes and its complications. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1521281"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12943-020-01278-3","article-title":"Exosome-based immunotherapy: A promising approach for cancer treatment","volume":"19","author":"Xu","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"105692","DOI":"10.1016\/j.phrs.2021.105692","article-title":"The role of extracellular vesicles in regulating local and systemic inflammation in cardiovascular disease","volume":"170","author":"Ohayon","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e30630","DOI":"10.1016\/j.heliyon.2024.e30630","article-title":"Plant-derived exosome-like nanovesicles: A novel nanotool for disease therapy","volume":"10","author":"Jin","year":"2024","journal-title":"Heliyon"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"12793","DOI":"10.2147\/IJN.S496664","article-title":"Engineering Strategies of Plant-Derived Exosome-Like Nanovesicles: Current Knowledge and Future Perspectives","volume":"19","author":"Li","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.2147\/IJN.S420748","article-title":"Plant-Derived Exosome-Like Nanovesicles: Current Progress and Prospects","volume":"18","author":"Mu","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kim, K., Park, J., Sohn, Y., Oh, C.-E., Park, J.-H., Yuk, J.-M., and Yeon, J.-H. (2022). Stability of Plant Leaf-Derived Extracellular Vesicles According to Preservative and Storage Temperature. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14020457"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.1021\/acs.jafc.2c00631","article-title":"Advances in Bioactivity of MicroRNAs of Plant-Derived Exosome-Like Nanoparticles and Milk-Derived Extracellular Vesicles","volume":"70","author":"Li","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1186\/s12951-025-03715-1","article-title":"Plant-derived exosome-like nanovesicles: A novel therapeutic perspective for skin diseases","volume":"23","author":"Liu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12951-023-01919-x","article-title":"Novel plant-derived exosome-like nanovesicles from Catharanthus roseus: Preparation, characterization, and immunostimulatory effect via TNF-\u03b1\/NF-\u03baB\/PU.1 axis","volume":"21","author":"Ou","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jplph.2018.07.006","article-title":"Protein biocargo of citrus fruit-derived vesicles reveals heterogeneous transport and extracellular vesicle populations","volume":"229","author":"Pocsfalvi","year":"2018","journal-title":"J. Plant Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12951-023-01858-7","article-title":"Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human disease and therapeutic modalities","volume":"21","author":"Xu","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5596","DOI":"10.7150\/thno.73650","article-title":"Turmeric-derived nanovesicles as novel nanobiologics for targeted therapy of ulcerative colitis","volume":"12","author":"Gao","year":"2022","journal-title":"Theranostics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1016\/j.ymthe.2021.05.005","article-title":"Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12","volume":"29","author":"Teng","year":"2021","journal-title":"Mol. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jconrel.2024.01.060","article-title":"Brucea javanica derived exosome-like nanovesicles deliver miRNAs for cancer therapy","volume":"367","author":"Yan","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Yu, Y., Zhu, G., Zeng, L., Xu, S., Cheng, H., Ouyang, Z., Chen, J., Pathak, J.L., and Wu, L. (2022). The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.896745"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1097\/HEP.0000000000000520","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"78","author":"Korenjak","year":"2023","journal-title":"Hepatology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e70132","DOI":"10.1002\/edm2.70132","article-title":"Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Mechanisms, Clinical Implications and Therapeutic Advances","volume":"8","author":"Miller","year":"2025","journal-title":"Endocrinol. Diabetes Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s42255-024-01043-6","article-title":"An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"6","author":"Vacca","year":"2024","journal-title":"Nat. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12944-024-02108-x","article-title":"Updated mechanisms of MASLD pathogenesis","volume":"23","author":"Li","year":"2024","journal-title":"Lipids Health Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2024.04.031","article-title":"EASL\u2013EASD\u2013EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"81","author":"Tacke","year":"2024","journal-title":"J. Hepatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/s41423-025-01307-5","article-title":"Immunopathogenic mechanisms and immunoregulatory therapies in MASLD","volume":"22","author":"He","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1056\/NEJMoa2401943","article-title":"Tirzepatide for Metabolic Dysfunction\u2013Associated Steatohepatitis with Liver Fibrosis","volume":"391","author":"Loomba","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jhep.2025.02.033","article-title":"Integrative metabolism in MASLD and MASH: Pathophysiology and emerging mechanisms","volume":"83","author":"Steinberg","year":"2025","journal-title":"J. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Kuentzel, K.B., Trammell, S.A.J., Hassing, A.S., Bradi\u0107, I., Damgaard, M., Fals, E.B., Michler, K.T., Dooley, M., Jacobsen, J.C.B., and Suppli, M.P. (2026). Arachidonoyl-taurine is elevated in human MASLD and protects against hepatic steatosis and inflammation in preclinical models. J. Hepatol.","DOI":"10.1016\/j.jhep.2026.04.033"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"118646","DOI":"10.1016\/j.jep.2024.118646","article-title":"Specnuezhenide ameliorates hepatic fibrosis via regulating SIRT6-Mediated inflammatory signaling cascades","volume":"335","author":"Qin","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jhep.2023.03.038","article-title":"An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH","volume":"79","author":"Tacke","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Shi, S., Zhou, Y., Zhang, H., and Zhang, J. (2025). TREM2 in MASH: Integrating lipid metabolism and immune response. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1604837"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e70190","DOI":"10.1111\/liv.70190","article-title":"Pathogenesis, Non-Invasive Assessments and Treatment of Hepatic Fibrosis in Autoimmune Liver Diseases","volume":"45","author":"Lytvyak","year":"2025","journal-title":"Liver Int."},{"key":"ref_39","first-page":"e0602","article-title":"Key role of macrophages in the progression of hepatic fibrosis","volume":"9","author":"Zhao","year":"2024","journal-title":"Hepatol. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"168062","DOI":"10.1016\/j.bbadis.2025.168062","article-title":"Interactions between hepatic stellate cells and immune cells: Implications for liver fibrosis","volume":"1872","author":"Xie","year":"2026","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"ref_41","first-page":"e0893","article-title":"Hepatocyte\u2013hepatic stellate cell interactions in liver fibrosis: Mechanisms and therapeutic implications","volume":"10","author":"Hong","year":"2026","journal-title":"Hepatol. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1080\/15548627.2020.1834711","article-title":"TXNIP\/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation","volume":"17","author":"Park","year":"2021","journal-title":"Autophagy"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Tauil, R.B., Golono, P.T., de Lima, E.P., de Alvares Goulart, R., Guiguer, E.L., Bechara, M.D., Nicolau, C.C.T., Yanaguizawa Junior, J.L., Fiorini, A.M.R., and M\u00e9ndez-S\u00e1nchez, N. (2024). Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols. Pharmaceuticals, 17.","DOI":"10.3390\/ph17101354"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wang, X., Rao, J., Tan, Z., Xun, T., Zhao, J., and Yang, X. (2022). Inflammatory signaling on cytochrome P450-mediated drug metabolism in hepatocytes. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1043836"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s00018-023-05061-7","article-title":"Contributing roles of mitochondrial dysfunction and hepatocyte apoptosis in liver diseases through oxidative stress, post-translational modifications, inflammation, and intestinal barrier dysfunction","volume":"81","author":"LeFort","year":"2024","journal-title":"Cell Mol. Life Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.14336\/AD.2019.0116","article-title":"Pyroptosis in Liver Disease: New Insights into Disease Mechanisms","volume":"10","author":"Wu","year":"2019","journal-title":"Aging Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41590-025-02088-9","article-title":"Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants","volume":"26","author":"Feng","year":"2025","journal-title":"Nat. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.7150\/ijbs.47143","article-title":"Kupffer Cells in Non-alcoholic Fatty Liver Disease: Friend or Foe?","volume":"16","author":"Chen","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cmet.2017.03.004","article-title":"Imbalanced Insulin Actions in Obesity and Type 2 Diabetes: Key Mouse Models of Insulin Signaling Pathway","volume":"25","author":"Kubota","year":"2017","journal-title":"Cell Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.3748\/wjg.v29.i25.3999","article-title":"Insulin resistance and adipose tissue interactions as the cornerstone of metabolic (dysfunction)-associated fatty liver disease pathogenesis","volume":"29","author":"Pal","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1053\/j.gastro.2012.02.003","article-title":"Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications","volume":"142","author":"Cusi","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1097-2765(05)00015-8","article-title":"Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction","volume":"6","author":"Michael","year":"2000","journal-title":"Mol. Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1126\/science.1160794","article-title":"A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance","volume":"322","author":"Sabio","year":"2008","journal-title":"Science"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.2337\/diabetes.54.12.3458","article-title":"Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor-\u03baB Pathway in Rat Liver","volume":"54","author":"Boden","year":"2005","journal-title":"Diabetes"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Abenavoli, L., Maurizi, V., Rinninella, E., Tack, J., Di Berardino, A., Santori, P., Rasetti, C., Procopio, A.C., Boccuto, L., and Scarpellini, E. (2022). Fecal Microbiota Transplantation in NAFLD Treatment. Medicina, 58.","DOI":"10.3390\/medicina58111559"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Mori, H., Svegliati Baroni, G., Marzioni, M., Di Nicola, F., Santori, P., Maroni, L., Abenavoli, L., and Scarpellini, E. (2022). Farnesoid X Receptor, Bile Acid Metabolism, and Gut Microbiota. Metabolites, 12.","DOI":"10.3390\/metabo12070647"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Pinart, M., D\u00f6tsch, A., Schlicht, K., Laudes, M., Bouwman, J., Forslund, S.K., Pischon, T., and Nimptsch, K. (2022). Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis. Nutrients, 14.","DOI":"10.3390\/nu14010012"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12944-021-01440-w","article-title":"Compositional alterations of gut microbiota in nonalcoholic fatty liver disease patients: A systematic review and Meta-analysis","volume":"20","author":"Li","year":"2021","journal-title":"Lipids Health Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.aohep.2019.04.006","article-title":"Microbiota and nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis (NAFLD\/NASH)","volume":"18","author":"Duarte","year":"2019","journal-title":"Ann. Hepatol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Li, L., Cai, F., Guo, C., Liu, Z., Qin, J., and Huang, J. (2024). Gut microbiome and NAFLD: Impact and therapeutic potential. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1500453"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Fang, J., Yu, C.-H., Li, X.-J., Yao, J.-M., Fang, Z.-Y., Yoon, S.-H., and Yu, W.-Y. (2022). Gut dysbiosis in nonalcoholic fatty liver disease: Pathogenesis, diagnosis, and therapeutic implications. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.997018"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1111\/liv.14696","article-title":"Intestinal permeability in human nonalcoholic fatty liver disease: A systematic review and meta-analysis","volume":"40","author":"Xu","year":"2020","journal-title":"Liver Int."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: A narrative review","volume":"19","author":"Petito","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Xu, S., Li, X., Zhang, S., Qi, C., Zhang, Z., Ma, R., Xiang, L., Chen, L., Zhu, Y., and Tang, C. (2023). Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn\u2019s disease: A multi-omics Mendelian randomization study. BMC Med., 21.","DOI":"10.1186\/s12916-023-02878-8"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/gutjnl-2024-332398","article-title":"Interplay between gut microbiome, host genetic and epigenetic modifications in MASLD and MASLD-related hepatocellular carcinoma","volume":"74","author":"Ha","year":"2025","journal-title":"Gut"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Ni, Y., Lu, M., Xu, Y., Wang, Q., Gu, X., Li, Y., Zhuang, T., Xia, C., Zhang, T., and Gou, X.-j. (2022). The Role of Gut Microbiota-Bile Acids Axis in the Progression of Non-alcoholic Fatty Liver Disease. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.908011"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1136\/gutjnl-2017-314307","article-title":"Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD","volume":"67","author":"Jiao","year":"2018","journal-title":"Gut"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: Pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jhep.2013.12.019","article-title":"Altered profile of human gut microbiome is associated with cirrhosis and its complications","volume":"60","author":"Bajaj","year":"2014","journal-title":"J. Hepatol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"G675","DOI":"10.1152\/ajpgi.00152.2012","article-title":"Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation","volume":"303","author":"Bajaj","year":"2012","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Tyc, O., Kraus, N., Wiedemann, T., Erasmus, H.-P., Ortiz, C., Vasseur, J., Hourfar, K., Seidl, C., M\u00fccke, M.M., and Storf, H. (2025). Enterococcus faecium DNA in acute decompensated cirrhosis: A key player in inflammation and kidney dysfunction. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1629210"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2413197","DOI":"10.1002\/advs.202413197","article-title":"Advances in Fecal Microbiota Transplantation for Gut Dysbiosis-Related Diseases","volume":"12","author":"Hou","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"20503121241257486","DOI":"10.1177\/20503121241257486","article-title":"Fecal microbiota transplantation and next-generation therapies: A review on targeting dysbiosis in metabolic disorders and beyond","volume":"12","author":"Sahle","year":"2024","journal-title":"SAGE Open Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13568-023-01520-3","article-title":"The gut microbiota pathway mechanisms of diabetes","volume":"13","author":"Bajinka","year":"2023","journal-title":"AMB Express"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/hep.30690","article-title":"Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo-Controlled Trial","volume":"70","author":"Bajaj","year":"2019","journal-title":"Hepatology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.chom.2025.04.017","article-title":"The microbiome: An actor or stage for the beneficial action of probiotics, prebiotics, synbiotics, and postbiotics?","volume":"33","author":"Sanders","year":"2025","journal-title":"Cell Host Microbe"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Guti\u00e9rrez, B., and Domingo-Calap, P. (2020). Phage Therapy in Gastrointestinal Diseases. Microorganisms, 8.","DOI":"10.3390\/microorganisms8091420"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Airola, C., Severino, A., Porcari, S., Fusco, W., Mullish, B.H., Gasbarrini, A., Cammarota, G., Ponziani, F.R., and Ianiro, G. (2023). Future Modulation of Gut Microbiota: From Eubiotics to FMT, Engineered Bacteria, and Phage Therapy. Antibiotics, 12.","DOI":"10.3390\/antibiotics12050868"},{"key":"ref_80","first-page":"1107","article-title":"Expert Consensus on Clinical Applications of Fecal Microbiota Transplantation for Chronic Liver Disease (2025 edition)","volume":"13","author":"Zhou","year":"2025","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1186\/s12967-025-07037-6","article-title":"Mechanistic insights into post-translational modifications in hepatic fibrosis: Pathogenic roles and therapeutic potentials","volume":"23","author":"Bai","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/MCG.0000000000000708","article-title":"Hepatocellular Carcinoma Surveillance Among Patients with Cirrhosis in a Population-based Integrated Health Care Delivery System","volume":"51","author":"Chubak","year":"2017","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.jhep.2017.07.027","article-title":"Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD","volume":"67","author":"Nasr","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/j.gastro.2018.04.034","article-title":"Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients with Advanced Nonalcoholic Fatty Liver Disease: A Multi-National Cohort Study","volume":"155","author":"Castellanos","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5919","DOI":"10.3748\/wjg.v26.i39.5919","article-title":"Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease","volume":"26","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s12015-021-10286-9","article-title":"Stem Cell-based Therapy Strategy for Hepatic Fibrosis by Targeting Intrahepatic Cells","volume":"18","author":"Deng","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2613502","DOI":"10.1080\/07853890.2026.2613502","article-title":"Advances in pharmacological interventions for hepatic fibrosis: From pathogenic mechanisms to novel therapeutic targets","volume":"58","author":"Zhang","year":"2026","journal-title":"Ann. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2445780","DOI":"10.1080\/07853890.2024.2445780","article-title":"Research advances in the diagnosis and treatment of MASLD\/MASH","volume":"57","author":"Wang","year":"2025","journal-title":"Ann. Med."},{"key":"ref_89","first-page":"e86963","article-title":"Pathological Evolution and Internal Medicine Management of Nonalcoholic Fatty Liver Disease (NAFLD) in the Era of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)","volume":"17","author":"Hashim","year":"2025","journal-title":"Cureus"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/JCMA.0000000000001254","article-title":"Complexity of metabolic dysfunction\u2013associated steatotic liver disease: State of the art review","volume":"88","author":"Tsai","year":"2025","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1001\/jama.2024.10816","article-title":"Medications for Obesity: A Review","volume":"332","author":"Gudzune","year":"2024","journal-title":"JAMA"},{"key":"ref_92","first-page":"e80321","article-title":"Comparative Effectiveness of Semaglutide, Liraglutide, Orlistat, and Phentermine for Weight Loss in Obese Individuals: A Systematic Review","volume":"17","author":"Patel","year":"2025","journal-title":"Cureus"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Liu, Q.K. (2024). Mechanisms of action and therapeutic applications of GLP-1 and dual GIP\/GLP-1 receptor agonists. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1431292"},{"key":"ref_94","first-page":"487","article-title":"Chronic Disease Management Branch of China Medical Biotechnology Association; Chinese Research Hospital Society; Chinese Society of General Practice, Chinese Medical Association; Expert Group of Guidelines for Diagnosis; Management of Metabolic Dysfunction-associated Fatty Liver Disease in Primary Care. Guidelines for Diagnosis and Management of Metabolic Dysfunction-associated Fatty Liver Disease in Primary Care (2025)","volume":"14","author":"Ni","year":"2026","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e186425","DOI":"10.1172\/JCI186425","article-title":"Therapeutic horizons in metabolic dysfunction\u2013associated steatohepatitis","volume":"135","author":"Newsome","year":"2025","journal-title":"J. Clin. Investig."},{"key":"ref_96","first-page":"111435","article-title":"Efficacy and safety of anti-obesity drugs in metabolic dysfunction-associated steatotic liver disease: An updated review","volume":"31","year":"2025","journal-title":"World J. Gastroenterol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e12404","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"8433","DOI":"10.1021\/acsnano.4c16854","article-title":"Surface Components and Biological Interactions of Extracellular Vesicles","volume":"19","author":"Wang","year":"2025","journal-title":"ACS Nano"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13287-025-04330-5","article-title":"Small extracellular vesicles: The origins, current status, future prospects, and applications","volume":"16","author":"Zhou","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2401069","DOI":"10.1002\/advs.202401069","article-title":"Extracellular Vesicle Preparation and Analysis: A State-of-the-Art Review","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Yang, L., Huang, S., Zhang, Z., Liu, Z., and Zhang, L. (2022). Roles and Applications of Red Blood Cell-Derived Extracellular Vesicles in Health and Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23115927"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.amjmed.2023.03.026","article-title":"Prediction of Post-Acute-Sequelae of COVID-19 by Cargo Protein Biomarkers of Blood Total Extracellular Vesicles in Acute COVID-19","volume":"136","author":"Goetzl","year":"2023","journal-title":"Am. J. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e12400","DOI":"10.1002\/jev2.12400","article-title":"A beginner\u2019s guide to study extracellular vesicles in human blood plasma and serum","volume":"13","author":"Nieuwland","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12943-022-01509-9","article-title":"Exosomes as a new frontier of cancer liquid biopsy","volume":"21","author":"Yu","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e12432","DOI":"10.1002\/jev2.12432","article-title":"Surface protein profiling and subtyping of extracellular vesicles in body fluids reveals non-CSF biomarkers of Alzheimer\u2019s disease","volume":"13","author":"Cai","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Wu, J., Liu, G., Jia, R., and Guo, J. (2023). Salivary Extracellular Vesicles: Biomarkers and Beyond in Human Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242417328"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/bs.acc.2019.12.003","article-title":"Chapter Three-Advances in extracellular vesicles analysis","volume":"Volume 97","author":"Makowski","year":"2020","journal-title":"Advances in Clinical Chemistry"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Lu, Y., Liu, D., Feng, Q., and Liu, Z. (2020). Diabetic Nephropathy: Perspective on Extracellular Vesicles. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00943"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Simeone, P., Bologna, G., Lanuti, P., Pierdomenico, L., Guagnano, M.T., Pieragostino, D., Del Boccio, P., Vergara, D., Marchisio, M., and Miscia, S. (2020). Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072514"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Zhang, B., Zhao, M., and Lu, Q. (2021). Extracellular Vesicles in Rheumatoid Arthritis and Systemic Lupus Erythematosus: Functions and Applications. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.575712"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"177976","DOI":"10.1016\/j.ejphar.2025.177976","article-title":"Extracellular vesicles as multiorgan crosstalk mediators in cardiovascular diseases: Emerging biomarkers and therapeutic targets","volume":"1004","author":"Meng","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.xphs.2018.11.022","article-title":"The Potential of Exosomes From Cow Milk for Oral Delivery","volume":"108","author":"Betker","year":"2019","journal-title":"J. Pharm. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13000-018-0768-y","article-title":"Bacterial outer membrane vesicles, a potential vaccine candidate in interactions with host cells based","volume":"13","author":"Cai","year":"2018","journal-title":"Diagn. Pathol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ymthe.2020.11.030","article-title":"Plant Exosome-like Nanovesicles: Emerging Therapeutics and Drug Delivery Nanoplatforms","volume":"29","author":"Dad","year":"2021","journal-title":"Mol. Ther."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"108092","DOI":"10.1016\/j.biotechadv.2022.108092","article-title":"Alternative biological sources for extracellular vesicles production and purification strategies for process scale-up","volume":"63","author":"Giancaterino","year":"2023","journal-title":"Biotechnol. Adv."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e12048","DOI":"10.1002\/jev2.12048","article-title":"A call for Rigor and standardization in plant extracellular vesicle research","volume":"10","author":"Pinedo","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.7150\/thno.97096","article-title":"Exosome-like nanoparticles derived from fruits, vegetables, and herbs: Innovative strategies of therapeutic and drug delivery","volume":"14","author":"Zhao","year":"2024","journal-title":"Theranostics"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Hade, M.D., Suire, C.N., and Suo, Z. (2021). Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine. Cells, 10.","DOI":"10.3390\/cells10081959"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41582-018-0126-4","article-title":"Exosomes\u2014beyond stem cells for restorative therapy in stroke and neurological injury","volume":"15","author":"Zhang","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1186\/s12967-025-07101-1","article-title":"Plant-derived extracellular vesicles: Composition, function and clinical potential","volume":"23","author":"Huang","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.2147\/IJN.S264498","article-title":"Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications","volume":"15","author":"Zhang","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jgr.2024.01.001","article-title":"Ginseng root-derived exosome-like nanoparticles protect skin from UV irradiation and oxidative stress by suppressing activator protein-1 signaling and limiting the generation of reactive oxygen species","volume":"48","author":"Choi","year":"2024","journal-title":"J. Ginseng Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s13770-021-00367-8","article-title":"The Antioxidant Effect of Small Extracellular Vesicles Derived from Aloe vera Peels for Wound Healing","volume":"18","author":"Kim","year":"2021","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s12010-018-2913-1","article-title":"In Vitro Wound Healing Activity of Wheat-Derived Nanovesicles","volume":"188","author":"Kala","year":"2019","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"7520","DOI":"10.1039\/D3FO01094E","article-title":"Garlic-derived exosome-like nanovesicles alleviate dextran sulphate sodium-induced mouse colitis via the TLR4\/MyD88\/NF-\u03baB pathway and gut microbiota modulation","volume":"14","author":"Zhu","year":"2023","journal-title":"Food Funct."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12951-022-01421-w","article-title":"Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy","volume":"20","author":"Liu","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.apsb.2021.08.016","article-title":"Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation","volume":"12","author":"Chen","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/20415990.2024.2354119","article-title":"Exosomes isolated from citrus lemon: A promising candidate for the treatment of Alzheimer\u2019s disease","volume":"15","author":"Dolma","year":"2024","journal-title":"Ther. Deliv."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1016\/j.scib.2024.10.027","article-title":"Targeting modulation of intestinal flora through oral route by an antimicrobial nucleic acid-loaded exosome-like nanovesicles to improve Parkinson\u2019s disease","volume":"69","author":"Cui","year":"2024","journal-title":"Sci. Bull."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41401-021-00681-w","article-title":"Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress","volume":"43","author":"Zhao","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","article-title":"A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis","volume":"390","author":"Harrison","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"115682","DOI":"10.1016\/j.foodres.2025.115682","article-title":"Plant polyphenols as natural bioactives for alleviating lipid metabolism disorder: Mechanisms and application challenges","volume":"203","author":"Wei","year":"2025","journal-title":"Food Res. Int."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2446391","DOI":"10.1080\/19490976.2024.2446391","article-title":"Gut microbiota-derived 4-hydroxyphenylacetic acid from resveratrol supplementation prevents obesity through SIRT1 signaling activation","volume":"17","author":"Wang","year":"2025","journal-title":"Gut Microbes"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"12340","DOI":"10.1021\/acs.jafc.4c00523","article-title":"Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2\/GPx4 Pathway","volume":"72","author":"Zhang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Ding, S.-B., Chu, X.-L., Jin, Y.-X., Jiang, J.-J., Zhao, X., and Yu, M. (2023). Epigallocatechin gallate alleviates high-fat diet-induced hepatic lipotoxicity by targeting mitochondrial ROS-mediated ferroptosis. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1148814"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Shabbir, U., Rubab, M., Daliri, E.B.-M., Chelliah, R., Javed, A., and Oh, D.-H. (2021). Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota. Nutrients, 13.","DOI":"10.3390\/nu13010206"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"104665","DOI":"10.1016\/j.fitote.2020.104665","article-title":"Tetrahydrocurcumin ameliorates diabetes profiles of db\/db mice by altering the composition of gut microbiota and up-regulating the expression of GLP-1 in the pancreas","volume":"146","author":"Yuan","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"110351","DOI":"10.1016\/j.biopha.2020.110351","article-title":"Dendrobium nobile Lindl. alkaloids-mediated protection against CCl4-induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway","volume":"129","author":"Zhou","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"110375","DOI":"10.1016\/j.intimp.2023.110375","article-title":"Leonurine alleviates acetaminophen-induced acute liver injury by regulating the PI3K\/AKT signaling pathway in mice","volume":"120","author":"Yu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Zhu, X., Bian, H., and Gao, X. (2016). The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease. Molecules, 21.","DOI":"10.3390\/molecules21101336"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/jgh.70201","article-title":"Effects of Piperine on Obese and Lean Nonalcoholic Fatty Liver Disease in Mice","volume":"41","author":"Fan","year":"2026","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12986-018-0250-6","article-title":"Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1\u03b2","volume":"15","author":"Miyazawa","year":"2018","journal-title":"Nutr. Metab."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Zhang, L., Wu, X., Yang, R., Chen, F., Liao, Y., Zhu, Z., Wu, Z., Sun, X., and Wang, L. (2021). Effects of Berberine on the Gastrointestinal Microbiota. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.588517"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Wan, X., Ma, J., Bai, H., Hu, X., Ma, Y., Zhao, M., Liu, J., and Duan, Z. (2025). Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs. Biomolecules, 15.","DOI":"10.3390\/biom15010140"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Nguyen, H.N., Ullevig, S.L., Short, J.D., Wang, L., Ahn, Y.J., and Asmis, R. (2021). Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits. Antioxidants, 10.","DOI":"10.3390\/antiox10081161"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"11647","DOI":"10.1021\/acs.jafc.8b04116","article-title":"Ursolic Acid, a Novel Liver X Receptor \u03b1 (LXR\u03b1) Antagonist Inhibiting Ligand-Induced Nonalcoholic Fatty Liver and Drug-Induced Lipogenesis","volume":"66","author":"Lin","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Li, S., Meng, F., Liao, X., Wang, Y., Sun, Z., Guo, F., Li, X., Meng, M., Li, Y., and Sun, C. (2014). Therapeutic Role of Ursolic Acid on Ameliorating Hepatic Steatosis and Improving Metabolic Disorders in High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Rats. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0086724"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1972746","DOI":"10.1080\/19490976.2021.1972746","article-title":"Ursolic acid reverses liver fibrosis by inhibiting NOX4\/NLRP3 inflammasome pathways and bacterial dysbiosis","volume":"13","author":"Nie","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"6699560","DOI":"10.1155\/2021\/6699560","article-title":"Exploring the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Glycyrrhizic and Glycyrrhetinic Acids","volume":"2021","author":"Richard","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Li, J.-Z., Chen, N., Ma, N., and Li, M.-R. (2023). Mechanism and Progress of Natural Products in the Treatment of NAFLD-Related Fibrosis. Molecules, 28.","DOI":"10.3390\/molecules28237936"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.1021\/acs.jafc.1c02257","article-title":"Oleanolic Acid Targets the Gut\u2013Liver Axis to Alleviate Metabolic Disorders and Hepatic Steatosis","volume":"69","author":"Xue","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"155919","DOI":"10.1016\/j.phymed.2024.155919","article-title":"Yellow tea polysaccharides protect against non-alcoholic fatty liver disease via regulation of gut microbiota and bile acid metabolism in mice","volume":"133","author":"Huang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.1039\/D3FO01691A","article-title":"Large yellow tea polysaccharides ameliorate obesity-associated metabolic syndrome by promoting M2 polarization of adipose tissue macrophages","volume":"14","author":"Wang","year":"2023","journal-title":"Food Funct."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"7230","DOI":"10.1021\/acs.jafc.4c00616","article-title":"Large Yellow Tea Polysaccharide Alleviates HFD-Induced Intestinal Homeostasis Dysbiosis via Modulating Gut Barrier Integrity, Immune Responses, and the Gut Microbiome","volume":"72","author":"Ma","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Zhang, J., and Feng, Q. (2022). Pharmacological Effects and Molecular Protective Mechanisms of Astragalus Polysaccharides on Nonalcoholic Fatty Liver Disease. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.854674"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"129036","DOI":"10.1016\/j.ijbiomac.2023.129036","article-title":"The polysaccharides from the fruits of Lycium barbarum ameliorate high-fat and high-fructose diet-induced cognitive impairment via regulating blood glucose and mediating gut microbiota","volume":"258","author":"Tian","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"111408","DOI":"10.1016\/j.foodres.2022.111408","article-title":"Mechanism of glycometabolism regulation by bioactive compounds from the fruits of Lycium barbarum: A review","volume":"159","author":"Liu","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"23344","DOI":"10.1021\/acs.jafc.5c04523","article-title":"Citrus Exosome-like Nanoparticles Reversed High-Fat Diet-Induced Microbiota Dysbiosis and Associated Short-Chain Fatty Acid Production","volume":"73","author":"Zhan","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.2147\/IJN.S478589","article-title":"Tangerine Peel-Derived Exosome-Like Nanovesicles Alleviate Hepatic Steatosis Induced by Type 2 Diabetes: Evidenced by Regulating Lipid Metabolism and Intestinal Microflora","volume":"19","author":"Zou","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"117532","DOI":"10.1016\/j.biopha.2024.117532","article-title":"Protective effects of lemon nanovesicles: Evidence of the Nrf2\/HO-1 pathway contribution from in vitro hepatocytes and in vivo high-fat diet-fed rats","volume":"180","author":"Gasparro","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"105734","DOI":"10.1016\/j.jff.2023.105734","article-title":"Pomegranate-derived exosome-like nanovesicles ameliorate high-fat diet-induced nonalcoholic fatty liver disease via alleviating mitochondrial dysfunction","volume":"108","author":"Hou","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.7150\/thno.65427","article-title":"Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut\/brain axis","volume":"12","author":"Sundaram","year":"2022","journal-title":"Theranostics"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"154679","DOI":"10.1016\/j.phymed.2023.154679","article-title":"Garlic-derived exosomes regulate PFKFB3 expression to relieve liver dysfunction in high-fat diet-fed mice via macrophage-hepatocyte crosstalk","volume":"112","author":"Liu","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"105997","DOI":"10.1016\/j.jff.2023.105997","article-title":"Kidney bean derived exosome-like nanovesicles ameliorate high-fat diet-induced obesity via reshaping gut microbiota","volume":"113","author":"Pang","year":"2024","journal-title":"J. Funct. Foods"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.7150\/thno.62514","article-title":"Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance","volume":"12","author":"Kumar","year":"2022","journal-title":"Theranostics"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"23117","DOI":"10.1021\/acsnano.4c05309","article-title":"Development and Evaluation of Reconstructed Nanovesicles from Turmeric for Multifaceted Obesity Intervention","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s12951-023-02120-w","article-title":"Natural exosomes-like nanoparticles in mung bean sprouts possesses anti-diabetic effects via activation of PI3K\/Akt\/GLUT4\/GSK-3\u03b2 signaling pathway","volume":"21","author":"He","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Zhang, F., Liu, R., Xu, T., Xu, W., Huang, K., and He, X. (2026). Broccoli-Derived Exosome-like Nanoparticles Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease Through Modulating the Gut\u2013Liver Axis. Nutrients, 18.","DOI":"10.3390\/nu18060953"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"94907986","DOI":"10.26599\/NR.2025.94907986","article-title":"Honeysuckle-derived exosome-like nanovesicles ameliorate metabolic-associated fatty liver disease by modulating gut microbiota and its metabolites","volume":"18","author":"Li","year":"2025","journal-title":"Nano Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40643-025-00844-1","article-title":"Tea leaf exosome-like nanoparticles (TELNs) improve oleic acid-induced lipid metabolism by regulating miRNAs in HepG-2 cells","volume":"12","author":"Lei","year":"2025","journal-title":"Bioresour. Bioprocess."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"36504","DOI":"10.1039\/D5RA03044G","article-title":"Changes in tea exosome-like nanoparticles fermented by Aspergillus cristatus and the preventive effects on non-alcoholic fatty liver disease","volume":"15","author":"Guo","year":"2025","journal-title":"RSC Adv."},{"key":"ref_172","first-page":"101105","article-title":"Ginseng-derived exosome-like nanovesicles protect against liver fibrosis by regulating TIMP2 pathways and gut dysbiosis","volume":"20","author":"Kim","year":"2025","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"116855","DOI":"10.1016\/j.biopha.2024.116855","article-title":"Investigating the proliferative inhibition of HepG2 cells by exosome-like nanovesicles derived from Centella asiatica extract through metabolomics","volume":"176","author":"Huang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"2502001","DOI":"10.1002\/smll.202502001","article-title":"Oral Plant-Derived Nanomedicines Mitigate Acetaminophen-Induced Liver Injury by Modulating the Gut-Liver Axis and Intestinal Microbiota Metabolism","volume":"21","author":"Chen","year":"2025","journal-title":"Small"}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/13\/9\/851\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:16:37Z","timestamp":1787631397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/13\/9\/851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,22]]},"references-count":174,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["vetsci13090851"],"URL":"https:\/\/doi.org\/10.3390\/vetsci13090851","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,22]]}}}