{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:18:27Z","timestamp":1787653107909,"version":"build-2736575974"},"reference-count":53,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Afyon Kocatepe University Scientific Research Coordination Unit","award":["25.VF.08."],"award-info":[{"award-number":["25.VF.08."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet. Sci.","Veterinary Sciences"],"abstract":"<jats:p>Pumpkin (Cucurbita pepo L.) seed oil (PSO) is rich in polyunsaturated fatty acids and bioactive compounds, but evidence regarding its biological effects in small ruminants remains limited. This study evaluated the effects of oral PSO supplementation in 45 clinically healthy weaned male P\u0131rlak lambs with a mean initial age of 119.64 \u00b1 35.25 days and a mean initial body weight of 37.55 \u00b1 9.77 kg, allocated to three groups: control (n = 9), 0.5 mL\/kg PSO (n = 18), and 1 mL\/kg PSO (n = 18). PSO was administered orally once daily for 45 days. Body weight was measured, and blood samples were collected on days 0, 15, 30, and 45. Serum growth hormone, immunoglobulin G (IgG), oxidative status, and selected biochemical parameters were evaluated. PSO supplementation did not significantly affect body weight gain or serum growth hormone concentrations. Total oxidant status was lower in both PSO groups than in the control group on day 30, whereas the oxidative stress index was lower in the 1 mL\/kg group than in the control group on day 45. Serum IgG concentrations were higher in the PSO groups throughout the study, although between-group differences were already present at baseline. Serum high-density lipoprotein cholesterol (HDL) concentrations increased over time, particularly in the 1 mL\/kg group, whereas low-density lipoprotein cholesterol (LDL) concentrations remained unchanged. Serum glucose concentrations decreased over time and were lower on day 45 than at baseline. No consistent dose-dependent adverse changes were observed in liver or kidney function indicators. Oral PSO supplementation did not improve growth performance but was associated with selective changes in oxidative balance and lipid metabolism without evident hepatic or renal adverse effects. Longer-term studies are required to confirm these effects and clarify their biological significance.<\/jats:p>","DOI":"10.3390\/vetsci13090859","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:04:30Z","timestamp":1787648670000},"page":"859","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Oral Pumpkin (Cucurbita pepo L.) Seed Oil Supplementation on Body Weight, Oxidative Status, Serum IgG Concentrations, and Serum Biochemical Parameters in Weaned P\u0131rlak Lambs"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7583-0488","authenticated-orcid":false,"given":"Mehmet Ali","family":"Erfidan","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, Emirda\u011f Vocational School, Afyon Kocatepe University, Afyonkarahisar 03600, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durmu\u015f Fatih","family":"Ba\u015fer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar 03204, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/10495398.2019.1674861","article-title":"Growth performance and carcass characteristics of finishing male lambs fed barberry pomace-containing diets","volume":"32","author":"Moghaddam","year":"2021","journal-title":"Anim. 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