{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:20:36Z","timestamp":1789395636191,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2023YFF1000903"],"award-info":[{"award-number":["2023YFF1000903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"China Agriculture Research System","award":["CARS-38"],"award-info":[{"award-number":["CARS-38"]}]},{"award":["CARS-38"],"award-info":[{"award-number":["CARS-38"]}],"id":[{"id":"https:\/\/ror.org\/03p5eky76","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Hainan Provincial Flexible Talent Introduction Collaborative Innovation Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet. Sci.","Veterinary Sciences"],"abstract":"<jats:p>Klebsiella pneumoniae (K. pneumoniae) belongs to the genus Klebsiella of the Enterobacteriaceae family. In goats, K. pneumoniae infection can result in respiratory diseases such as pneumonia and bronchopneumonia. In this study, caprine bronchial epithelial cells were infected with K. pneumoniae, and multi-omics integration analysis was conducted to investigate the immune defense mechanisms triggered by the infection. Enrichment analysis of differentially expressed genes (DEGs) using the KEGG database revealed that immune-related signaling pathways involving TNF and IL-17 were among the top 20 most enriched. Based on the TNF and IL-17 signaling pathways, ten immune pathway-related genes, including CCL20, CXCL1, TRAF4, FOS, IL6, PTGS2, TNF, CXCL8, TNFAIP3, and JUN, were selected for RT-qPCR validation. In addition, four miRNAs targeting genes involved in the above pathways, namely chi-miR-148a-5p, miR-1285-z, miR-16-x, and miR-6119-x, were verified by RT-qPCR. The expression trends of chi-miR-148a-5p and miR-1285-z were consistent with microRNA sequencing results. Furthermore, gain- and loss-of-function experiments indicated that chi-miR-148a-5p may target TNF and PTGS2, while miR-1285-z may target NFKBIZ, with CSF2 predicted as a potential target. This study suggests that chi-miR-148a-5p and miR-1285-z may participate in the TNF and IL-17 signaling pathways by regulating their predicted target genes. Moreover, the TNF and IL-17 signaling pathways are among the most highly enriched immune-related pathways involved in the innate immune response of caprine bronchial epithelial cells. This study provides insights into the molecular mechanisms underlying immune responses in goats infected with K. pneumoniae.<\/jats:p>","DOI":"10.3390\/vetsci13090953","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:05:26Z","timestamp":1789391126000},"page":"953","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of the Potential chi-miR-148a-5p-PTGS2 Regulatory Axis Mediating TNF and IL-17 Signaling Pathways in Caprine Bronchial Epithelial Cells Challenged with Klebsiella Pneumoniae"],"prefix":"10.3390","volume":"13","author":[{"given":"Yimei","family":"Chen","sequence":"first","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Zhenxing","family":"Gong","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"software","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Hui","family":"Jing","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"}]},{"given":"Hao","family":"Duan","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Hejie","family":"Qian","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Tengjiao","family":"Li","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Shihua","family":"Niu","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Lili","family":"Wu","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Ziying","family":"Wang","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Mengqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Yiwen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Churiga","family":"Man","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4442-9450","authenticated-orcid":false,"given":"Qiaoling","family":"Chen","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Li","family":"Du","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"given":"Hongyan","family":"Gao","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"given":"Fengyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, School of Animal Science and Veterinary Medicine, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/s41467-025-56309-8","article-title":"Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance","volume":"16","author":"Bray","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e0020622","DOI":"10.1128\/iai.00206-22","article-title":"Klebsiella pneumoniae l-Fucose Metabolism Promotes Gastrointestinal Colonization and Modulates Its Virulence Determinants","volume":"90","author":"Hudson","year":"2022","journal-title":"Infect. Immun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e01622-19","DOI":"10.1128\/AAC.01622-19","article-title":"Whole-Genome Sequencing To Identify Drivers of Carbapenem-Resistant Klebsiella pneumoniae Transmission within and between Regional Long-Term Acute-Care Hospitals","volume":"63","author":"Han","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Abbas, R., Chakkour, M., Zein El Dine, H., Obaseki, E.F., Obeid, S.T., Jezzini, A., Ghssein, G., and Ezzeddine, Z. (2024). General Overview of Klebsiella pneumonia: Epidemiology and the Role of Siderophores in Its Pathogenicity. Biology, 13.","DOI":"10.3390\/biology13020078"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1128\/CMR.11.4.589","article-title":"Klebsiella spp. as nosocomial pathogens: Epidemiology, taxonomy, typing methods, and pathogenicity factors","volume":"11","author":"Podschun","year":"1998","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/femsre\/fux013","article-title":"Klebsiella pneumoniae: A major worldwide source and shuttle for antibiotic resistance","volume":"41","author":"Kondratyeva","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"127839","DOI":"10.1016\/j.micres.2024.127839","article-title":"Hypervirulent and carbapenem-resistant Klebsiella pneumoniae: A global public health threat","volume":"288","author":"Lei","year":"2024","journal-title":"Microbiol. Res."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"He, M., Li, H., Zhang, Z., Jiang, J., Li, H., Yang, W., Cheng, Y., Gao, H., Chen, Q., and Du, L. (2022). Microbiological Characteristics and Pathogenesis of Klebsiella pneumoniae Isolated from Hainan Black Goat. Vet. Sci., 9.","DOI":"10.3390\/vetsci9090471"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"102077","DOI":"10.1016\/j.cimid.2023.102077","article-title":"Hypervirulent Klebsiella pneumoniae among diarrheic farm animals: A serious public health concern","volume":"102","author":"Mario","year":"2023","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_10","first-page":"170","article-title":"Antimicrobial resistance patterns of multidrug resistant ESBL-producing Escherichia coli and Klebsiella pneumoniae isolated from sheep and goats in Punjab, India","volume":"26","author":"Mushtaq","year":"2025","journal-title":"Iran. J. Vet. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Mahrous, S.H., El-Balkemy, F.A., Abo-Zeid, N.Z., El-Mekkawy, M.F., El Damaty, H.M., and Elsohaby, I. (2023). Antibacterial and Anti-Biofilm Activities of Cinnamon Oil against Multidrug-Resistant Klebsiella pneumoniae Isolated from Pneumonic Sheep and Goats. Pathogens, 12.","DOI":"10.3390\/pathogens12091138"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Chen, R., Shang, H., Niu, X., Huang, J., Miao, Y., Sha, Z., Qin, L., Huang, H., Peng, D., and Zhu, R. (2021). Establishment and evaluation of an indirect ELISA for detection of antibodies to goat Klebsiella pneumonia. BMC Vet. Res., 17.","DOI":"10.1186\/s12917-021-02820-1"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6697","DOI":"10.4049\/jimmunol.171.12.6697","article-title":"Outer membrane protein A from Klebsiella pneumoniae activates bronchial epithelial cells: Implication in neutrophil recruitment","volume":"171","author":"Pichavant","year":"2003","journal-title":"J. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2449722","DOI":"10.1080\/21505594.2025.2449722","article-title":"Klebsiella pneumoniae derived outer membrane vesicles mediated bacterial virulence, antibiotic resistance, host immune responses and clinical applications","volume":"16","author":"Li","year":"2025","journal-title":"Virulence"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"108794","DOI":"10.1016\/j.vetmic.2020.108794","article-title":"Cholesterol-rich lipid rafts both in cellular and viral membrane are critical for caprine parainfluenza virus type3 entry and infection in host cells","volume":"248","author":"Li","year":"2020","journal-title":"Vet. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e13047","DOI":"10.7717\/peerj.13047","article-title":"The mRNA and miRNA profiles of caprine bronchial epithelial cells stimulated by Pasteurella multocida strains of serotype A and D","volume":"10","author":"An","year":"2022","journal-title":"PeerJ"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Chen, Q., Chen, Z., Zhang, Z., Pan, H., Li, H., Li, X., An, Q., Cheng, Y., Chen, S., and Man, C. (2023). Profiling Chromatin Accessibility Responses in caprine bronchial Epithelial Cells Infected with Pasteurella multocida. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021312"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.fsi.2021.10.002","article-title":"Molecular identification of Klebsiella pneumoniae and expression of immune genes in infected spotted gar Lepisosteus oculatus","volume":"119","author":"Wu","year":"2021","journal-title":"Fish. Shellfish Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e16888","DOI":"10.15252\/emmm.202216888","article-title":"In vivo single-cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection","volume":"14","author":"Dumigan","year":"2022","journal-title":"EMBO Mol. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"101886","DOI":"10.1016\/j.xcrm.2024.101886","article-title":"High-alcohol-producing Klebsiella pneumoniae aggravates lung injury by affecting neutrophils and the airway epithelium","volume":"6","author":"Cui","year":"2025","journal-title":"Cell Rep. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jaci.2017.08.034","article-title":"MicroRNA","volume":"141","author":"Lu","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1111\/febs.16422","article-title":"The intricate balance between microRNA-induced mRNA decay and translational repression","volume":"290","author":"Naeli","year":"2023","journal-title":"FEBS J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.7150\/ijbs.86492","article-title":"The PTGS2\/COX2-PGE(2) signaling cascade in inflammation: Pro or anti? A case study with type 1 diabetes mellitus","volume":"19","author":"Lorenzo","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41577-022-00792-3","article-title":"Death by TNF: A road to inflammation","volume":"23","author":"Bertrand","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Feng, Y., Chen, Z., Xu, Y., Han, Y., Jia, X., Wang, Z., Zhang, N., and Lv, W. (2023). The central inflammatory regulator I\u03baB\u03b6: Induction, regulation and physiological functions. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1188253"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.immuni.2019.03.022","article-title":"GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation","volume":"50","author":"Dougan","year":"2019","journal-title":"Immunity"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Huang, J., and Zhou, Q. (2022). Gene Biomarkers Related to Th17 Cells in Macular Edema of Diabetic Retinopathy: Cutting-Edge Comprehensive Bioinformatics Analysis and In Vivo Validation. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.858972"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"105806","DOI":"10.1016\/j.micpath.2022.105806","article-title":"Bovine skin fibroblasts mediated immune responses to defend against bovine Acinetobacter baumannii infection","volume":"173","author":"Hou","year":"2022","journal-title":"Microb. Pathog."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Pagin, M., Pernebrink, M., Pitasi, M., Malighetti, F., Ngan, C.-Y., Ottolenghi, S., Pavesi, G., Cant\u00f9, C., and Nicolis, S.K. (2021). FOS Rescues Neuronal Differentiation of Sox2-Deleted Neural Stem Cells by Genome-Wide Regulation of Common SOX2 and AP1(FOS-JUN) Target Genes. Cells, 10.","DOI":"10.3390\/cells10071757"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41419-021-04016-9","article-title":"The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging","volume":"12","author":"Jiang","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41392-024-01986-y","article-title":"MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"108183","DOI":"10.1016\/j.micpath.2025.108183","article-title":"PBMCs of Hainan Black goats mediate immune responses against Mannheimia haemolytica infection","volume":"210","author":"Wang","year":"2026","journal-title":"Microb. Pathog."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cyto.2011.09.016","article-title":"Bronchial epithelial cells release IL-6, CXCL1 and CXCL8 upon mast cell interaction","volume":"56","author":"Cao","year":"2011","journal-title":"Cytokine"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1465-9921-9-9","article-title":"Cryptococcus neoformans induces IL-8 secretion and CXCL1 expression by human bronchial epithelial cells","volume":"9","author":"Guillot","year":"2008","journal-title":"Respir. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"122134","DOI":"10.1016\/j.envres.2025.122134","article-title":"Pro-inflammatory effects of road wear particles and diesel exhaust particles in bronchial epithelial cells and macrophages","volume":"283","author":"Grytting","year":"2025","journal-title":"Environ. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e2500820122","DOI":"10.1073\/pnas.2500820122","article-title":"Epithelial Regnase-1 inhibits colorectal tumor growth by regulating IL-17 signaling via degradation of NFKBIZ mRNA","volume":"122","author":"Iguchi","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Svraka, L., Andersen, A.S., Touborg, T., Emmanuel, T., Gk, U., Kadarmideen, H.N., Bertelsen, T., Vestergaard, C., and Johansen, C. (2026). IL-17 Cytokines Induce I\u03baB\u03b6 in Dermal Fibroblasts to Promote Pro-Inflammatory Gene Expression in Psoriasis. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27031297"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.18332\/tid\/138227","article-title":"MiR-937 serves as an inflammatory inhibitor in cigarette smoke extract-induced human bronchial epithelial cells by targeting IL1B and regulating TNF-\u03b1\/IL-17 signaling pathway","volume":"19","author":"Liu","year":"2021","journal-title":"Tob. Induc. Dis."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/13\/9\/953\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:44:54Z","timestamp":1789393494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/13\/9\/953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,12]]},"references-count":38,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["vetsci13090953"],"URL":"https:\/\/doi.org\/10.3390\/vetsci13090953","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,12]]}}}