{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:10:18Z","timestamp":1760195418804,"version":"build-2065373602"},"reference-count":9,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T00:00:00Z","timestamp":1516406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>An 8-year-old male (neutered) Labrador with a history of erythematous skin lesions and exercise intolerance for a prolonged period was suddenly found dead. Necropsy findings revealed an infiltrative, focally extensive mass which occupied 25% of the cardiac interventricular septum. Severe endocardiosis was also found on the bicuspid and tricuspid valves. The submandibular lymph nodes and kidneys were bilaterally enlarged, and the pre-hepatic lymph node and spleen were also enlarged. Multiple dermal pustules were present around the mouth and on the ear, and small ulcers were present on the tongue. Histopathological examination detected the presence of neoplastic lymphocytes with a plasmacytoid morphology in these tissues as well as in the tongue and skin lesions. Immunohistochemical (CD3+\/CD18+) evaluation was consistent with a T-cell lymphoma, which could be classified as a peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS).<\/jats:p>","DOI":"10.3390\/vetsci5010010","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T04:51:13Z","timestamp":1516596673000},"page":"10","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Multicentric T-Cell Lymphoma with a Plasmacytoid Morphology in a Dog"],"prefix":"10.3390","volume":"5","author":[{"given":"Alissa","family":"Bally","sequence":"first","affiliation":[{"name":"The School of Veterinary Medicine, University of the West Indies, Saint Augustine, Trinidad and Tobago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5094-8866","authenticated-orcid":false,"given":"Karelma","family":"Acevedo","sequence":"additional","affiliation":[{"name":"The School of Veterinary Medicine, University of the West Indies, Saint Augustine, Trinidad and Tobago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5624-3341","authenticated-orcid":false,"given":"Indira","family":"Pargass","sequence":"additional","affiliation":[{"name":"The School of Veterinary Medicine, University of the West Indies, Saint Augustine, Trinidad and Tobago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana","family":"Gyan","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Laboratory, Ministry of Agriculture, Land and Fisheries, Eric Williams Medical Sciences Complex, Uriah Butler Highway, Mt Hope, Trinidad and Tobago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacy","family":"Rajh","sequence":"additional","affiliation":[{"name":"The School of Veterinary Medicine, University of the West Indies, Saint Augustine, Trinidad and Tobago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rod","family":"Suepaul","sequence":"additional","affiliation":[{"name":"The School of Veterinary Medicine, University of the West Indies, Saint Augustine, Trinidad and Tobago"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Meuten, D.J. (2017). Tumors of Domestic Animals, John Wiley & Sons, Inc.. [5th ed.].","DOI":"10.1002\/9781119181200"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1177\/0300985810363902","article-title":"A morphological study of 608 cases of canine malignant lymphoma in France with a focus on comparative similarities between canine and human lymphoma morphology","volume":"47","author":"Ponce","year":"2010","journal-title":"Vet. Pathol."},{"key":"ref_3","unstructured":"Valli, V.E.O., Kiupel, M., Bienzle, D., and Wood, D.R. (2016). Jubb, Kennedy and Palmer's Pathology of Domestic Animals Volume 3, Elsevier. [6th ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1177\/104063870301500405","article-title":"High-grade canine T-cell lymphoma\/leukemia with plasmacytoid morphology: A clinical pathological study of nine cases","volume":"15","author":"Ponce","year":"2003","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1136\/jcp.44.8.632","article-title":"Immunohistological diagnosis of \u201cplasmacytoid T cell lymphoma\u201d in paraffin wax sections","volume":"44","author":"Thomas","year":"1991","journal-title":"J. Clin. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1354\/vp.42-4-437","article-title":"Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors","volume":"42","author":"Fernandez","year":"2005","journal-title":"Vet. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1354\/vp.44-6-875","article-title":"Immunohistochemical detection of multiple myeloma 1\/interferon regulatory factor 4 (MUM1\/IRF-4) in canine plasmacytoma: Comparison with CD79a and CD20","volume":"44","author":"Miller","year":"2007","journal-title":"Vet. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1399-0039.1990.tb01831.x","article-title":"Canine leukocyte integrins: characterization of a CD18 homologue","volume":"36","author":"Moore","year":"1990","journal-title":"Tissue Antigen."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/vcp.12503","article-title":"A metastatic secretory gastric plasmacytoma with aberrant CD3 expression in a dog","volume":"46","author":"Atherton","year":"2017","journal-title":"Vet. Clin. 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