{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:05:24Z","timestamp":1760241924870,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","award":["U01-003-572"],"award-info":[{"award-number":["U01-003-572"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Shiga toxin-producing Escherichia coli, like E. coli O157:H7, are important human and animal pathogens. Naturally-acquired E. coli O157:H7 infections occur in numerous species but, particularly, cattle have been identified as a significant reservoir for human cases. E. coli O157:H7 are isolated from a number of domestic and wild animals, including rodents that share a living space with cattle. These Shiga toxin-producing E. coli O157:H7 strains can be highly virulent in humans, but little is known about the sequelae of interspecies transfer. In a group of neonatal calves, we determined the differences in colonization patterns and lesions associated with infection using either a wildlife or bovine E. coli O157:H7 strain. In calves challenged with the wildlife E. coli O157:H7 strain, the large (descending) colon was solely colonized, which differed substantially from the calves inoculated with the bovine E. coli O157:H7 strain, where the spiral colon was the principal target of infection. This study also demonstrated that while both interspecies- and intraspecies-derived E. coli O157:H7 can infect young calves, the distribution and severity differs.<\/jats:p>","DOI":"10.3390\/vetsci5040088","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T02:52:53Z","timestamp":1539658373000},"page":"88","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Pathogenicity of Wildlife and Bovine Escherichia coli O157:H7 Strains in Experimentally Inoculated Neonatal Jersey Calves"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4779-4816","authenticated-orcid":false,"given":"Elizabeth M.","family":"Antaki-Zukoski","sequence":"first","affiliation":[{"name":"Department of Population Health and Reproduction, University of California, Davis, CA 95616, USA"},{"name":"Western Institute for Food Safety and Security, University of California, Davis, CA 95618, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunde","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, University of California, Davis, CA 95616, USA"},{"name":"Western Institute for Food Safety and Security, University of California, Davis, CA 95618, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Pesavento","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of California, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran H. B.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, University of California, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce R.","family":"Hoar","sequence":"additional","affiliation":[{"name":"College of Agriculture and Natural Resources, University of Wyoming, Laramie, WY 82071, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward R.","family":"Atwill","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, University of California, Davis, CA 95616, USA"},{"name":"Western Institute for Food Safety and Security, University of California, Davis, CA 95618, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,15]]},"reference":[{"key":"ref_1","unstructured":"Centers for Disease Control and Prevention (2018, October 14). 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