{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T09:41:27Z","timestamp":1775209287418,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Pneumoperitoneum may induce important hemodynamic alterations in healthy subjects. Pulse pressure variation (PPV) is a hemodynamic parameter able to discriminate preload dependent subjects. Anesthesia records of dogs undergoing laparoscopy were retrospectively evaluated. The anesthetic protocol included acepromazine, methadone, propofol and isoflurane administered with oxygen under mechanical ventilation. The hemodynamic parameters were considered five minutes before (BASE) and ten minutes after (P10) the pneumoperitoneum. Based on the cardiac index (CI) variation, at P10, dogs were classified as sensitive (S group, CI \u2264 15%) and non-sensitive (NO-S group). Data were analyzed with the ANOVA test and the ROC curve (p &lt; 0.05). Fifty-five percent of dogs (S) had a reduction of CI \u2265 15% at P10 (2.97 \u00b1 1.4 L\/min\/m2) compared to BASE (4.32 \u00b1 1.62 L\/min\/m2) and at P10 in the NO-S group (4.51 \u00b1 1.41 L\/min\/m2). PPV at BASE was significantly higher in the S group (22.4% \u00b1 6.1%) compared to the NO-S group (10.9% \u00b1 3.3%). The ROC curve showed a threshold of PPV &gt; 16% to distinguish the S and NO-S groups. PPV may be a valid predictor of the hemodynamic response to pneumoperitoneum in dogs. A PPV &gt; 16% can identify patients that may require fluid administration before the creation of pneumoperitoneum.<\/jats:p>","DOI":"10.3390\/vetsci6010017","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T11:45:39Z","timestamp":1550663139000},"page":"17","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pulse Pressure Variation Can Predict the Hemodynamic Response to Pneumoperitoneum in Dogs: A Retrospective Study"],"prefix":"10.3390","volume":"6","author":[{"given":"Caterina","family":"Di Bella","sequence":"first","affiliation":[{"name":"PhD Course in Tissues and Organs Transplantation and Cellular Therapies, Department of Emergency and Organ Transplantation, University of Bari, 70010 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Lacitignola","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Section of Veterinary Clinics and Animal Production; University of Bari, 70010 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Fracassi","sequence":"additional","affiliation":[{"name":"PhD Course in Tissues and Organs Transplantation and Cellular Therapies, Department of Emergency and Organ Transplantation, University of Bari, 70010 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Despoina","family":"Skouropoulou","sequence":"additional","affiliation":[{"name":"PhD Course in Tissues and Organs Transplantation and Cellular Therapies, Department of Emergency and Organ Transplantation, University of Bari, 70010 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Crovace","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Section of Veterinary Clinics and Animal Production; University of Bari, 70010 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2085-376X","authenticated-orcid":false,"given":"Francesco","family":"Staffieri","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Section of Veterinary Clinics and Animal Production; University of Bari, 70010 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.4187\/respcare.03486","article-title":"Cardiorespiratory interactions: The relationship between mechanical ventilation and hemodynamics","volume":"59","author":"Cheifetz","year":"2014","journal-title":"Respir. Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00000542-200508000-00026","article-title":"Changes in arterial pressure during mechanical ventilation","volume":"103","author":"Michard","year":"2005","journal-title":"Anesthesiology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1053\/j.jvca.2009.10.008","article-title":"Arterial pressure variation and goal-directed fluid therapy","volume":"24","author":"Cannesson","year":"2010","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1186\/s13054-014-0650-6","article-title":"Does pulse pressure variation predict fluid responsiveness in critically ill patients? A systematic review and meta-analysis","volume":"18","author":"Yang","year":"2014","journal-title":"Crit. Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s00134-014-3285-9","article-title":"Respiratory variations in the arterial pressure during mechanical ventilation reflect volume status and fluid responsiveness","volume":"40","author":"Perel","year":"2014","journal-title":"Intensive Care Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1097\/CCM.0b013e3181a590da","article-title":"Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: A systematic review of the literature","volume":"37","author":"Marik","year":"2009","journal-title":"Crit. Care Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.vaa.2017.06.001","article-title":"Evaluation of the dynamic predictors of fluid responsiveness in dogs receiving goal-directed fluid therapy","volume":"45","author":"Drozdzynska","year":"2018","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/bja\/aei116","article-title":"Pulse pressure and stroke volume variations during severe haemorrhage in ventilated dogs","volume":"94","author":"Berkenstadt","year":"2005","journal-title":"Br. J. Anaesth."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/vec.12728","article-title":"Evaluation of pulse pressure variation and pleth variability index to predict fluid responsiveness in mechanically ventilated isoflurane-anesthetized dogs","volume":"28","author":"Sano","year":"2018","journal-title":"J. Vet. Emerg. Crit. Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.vaa.2016.11.011","article-title":"Pulse pressure variation as a guide for volume expansion in dogs undergoing orthopedic surgery","volume":"44","author":"Fantoni","year":"2017","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0022-4804(81)90156-6","article-title":"Hemodynamic effect of increased abdominal pressure","volume":"30","author":"Kashtan","year":"1981","journal-title":"J. Surg. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00464-001-9152-0","article-title":"The duration of hemodynamic depression during laparoscopic cholecystectomy","volume":"16","author":"Zuckerman","year":"2002","journal-title":"Surg. Endosc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.5582\/bst.2015.01029","article-title":"The impact of intra-abdominal pressure on the stroke volume variation and plethysmographic variability index in patients undergoing laparoscopic cholecystectomy","volume":"9","author":"Liu","year":"2015","journal-title":"Biosci. Trends"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1213\/00000539-199803000-00005","article-title":"Left ventricular loading modifications induced by pneumoperitoneum: A time course echocardiographic study","volume":"86","author":"Branche","year":"1998","journal-title":"Anesth. Analg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1152\/jappl.1990.69.6.1961","article-title":"Effects of abdominal pressure on venous return: Abdominal vascular zone conditions","volume":"69","author":"Takata","year":"1990","journal-title":"J. Appl. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Briganti, A., Evangelista, F., Centonze, P., Rizzo, A., Bentivegna, F., Crovace, A., and Staffieri, F. (2018). A preliminary study evaluating cardiac output measurement using Pressure Recording Analytical Method (PRAM) in anaesthetized dogs. BMC Vet. Res., 14.","DOI":"10.1186\/s12917-018-1392-5"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0140-6736(97)11478-7","article-title":"Cardiovascular consequences of laparoscopic surgery","volume":"352","author":"Struthers","year":"1998","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1034\/j.1399-6576.2000.440709.x","article-title":"Effects of carbon dioxide pneumoperitoneum for laparoscopic cholecystectomy","volume":"44","author":"Koivusalo","year":"2000","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1161\/CIRCULATIONAHA.116.023262","article-title":"Cardiovascular and Ventilatory Consequences of Laparoscopic Surgery","volume":"135","author":"Atkinson","year":"2017","journal-title":"Circulation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00000542-197503000-00008","article-title":"Cardiovascular effects of intraperitoneal insufflation with carbon dioxide and nitrous oxide in the dog","volume":"42","author":"Ivankovich","year":"1975","journal-title":"Anesthesiology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1532-950X.1996.tb01381.x","article-title":"Cardiopulmonary effects of using carbon dioxide for laparoscopic surgery in dogs","volume":"25","author":"Duke","year":"1996","journal-title":"Vet. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s004649900993","article-title":"Hemodynamic consequences of high- and low-pressure capnoperitoneum during laparoscopic cholecystectomy","volume":"13","author":"Dexter","year":"1999","journal-title":"Surg. Endosc."},{"key":"ref_23","first-page":"548","article-title":"Laparoscopy in high-risk cardiac patients","volume":"176","author":"Safran","year":"1993","journal-title":"Surg. Gynecol. Obstet."},{"key":"ref_24","first-page":"381","article-title":"The effects of CO2 pneumoperitoneum on hemodynamics in hemorrhaged animals","volume":"114","author":"Ho","year":"1993","journal-title":"Surgery"}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/6\/1\/17\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:33:28Z","timestamp":1760186008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/6\/1\/17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,20]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,3]]}},"alternative-id":["vetsci6010017"],"URL":"https:\/\/doi.org\/10.3390\/vetsci6010017","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,20]]}}}