{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:53:32Z","timestamp":1793444012566,"version":"4.5.0"},"reference-count":13,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/18426-1"],"award-info":[{"award-number":["2012\/18426-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Primary bladder leiomyosarcoma was diagnosed in a four-year-old, mixed-breed, spayed female cat that presented with lethargy, stranguria, polyuria, hematuria, urinary incontinence and abdominal sensitivity. On abdominal ultrasound, the urinary bladder was observed to have a preserved anatomical position and a hyperechoic mass. The mass measured approximately 1.5 cm, was irregular, and arose from the mucosa of the bladder wall. Due to the evidence of a primary tumor in the urinary bladder, we conducted a partial cystectomy with a 1.0 cm surgical margin and performed histopathology and immunohistochemistry. The histopathology revealed a poorly differentiated malignant neoplasm, characterized by the proliferation of spindle cells with moderate nuclear pleomorphism, suggestive of leiomyosarcoma. Immunohistochemistry confirmed the histopathological diagnosis, showing positive staining for vimentin, desmin and alpha-smooth muscle actin and negative staining for S100, pan-cytokeratin and MyoD1. We also assessed the proliferative index by Ki67 staining and found that 57% of the neoplastic cells were positive for Ki67. We conducted clinical follow-ups every three months in the first year and every six months thereafter. The patient showed no signs of recurrence after 48 months. The surgery was sufficient to treat the leiomyosarcoma, and adjuvant chemotherapy was not necessary in this case.<\/jats:p>","DOI":"10.3390\/vetsci6030060","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T09:41:13Z","timestamp":1561628473000},"page":"60","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long-Term Survival of a Cat with Primary Leiomyosarcoma of the Urinary Bladder"],"prefix":"10.3390","volume":"6","author":[{"given":"Anneliese Baetz","family":"Buzatto","sequence":"first","affiliation":[{"name":"Veterinary Oncology Specialization Course, Instituto Bioethicus, Botucatu SP 18605-545, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Elias","sequence":"additional","affiliation":[{"name":"Superintendencia Unidade Hospitalar Veterinaria Universitaria, Federal University of the Fronteira Sul, Realeza PR 85770-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara Sim\u00e3o","family":"Franzoni","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, University of Sao Paulo State \u2013 UNESP, Botucatu SP 18618-681, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6702-6139","authenticated-orcid":false,"given":"Carlos Eduardo","family":"Fonseca-Alves","sequence":"additional","affiliation":[{"name":"Veterinary Oncology Specialization Course, Instituto Bioethicus, Botucatu SP 18605-545, Brazil"},{"name":"Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, University of Sao Paulo State \u2013 UNESP, Botucatu SP 18618-681, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2460\/javma.231.1.101","article-title":"Clinical signs, treatments, and outcome in cats with transitional cell carcinoma of the urinary bladder: 20 cases (1990\u20132004)","volume":"231","author":"Wilson","year":"2007","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1177\/030098587901600208","article-title":"Transitional cell carcinoma in the domestic cat","volume":"16","author":"Wimberly","year":"1979","journal-title":"Vet. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1748-5827.1986.tb03961.x","article-title":"A histopathologic study of twenty urinary bladder neoplasms in the cat","volume":"27","author":"Patnaik","year":"1986","journal-title":"J. Small Anim. Pract."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jcpa.2010.08.002","article-title":"Lipoma of the urinary bladder in a cat","volume":"144","author":"Shirian","year":"2011","journal-title":"J. Comp. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1748-5827.2010.00911.x","article-title":"Extranodal B-cell lymphoma in the urinary bladder with cytological evidence of concurrent involvement of the gall bladder in a cat","volume":"51","author":"Geigy","year":"2010","journal-title":"J. Small Anim. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2460\/javma.236.3.291","article-title":"What is your diagnosis? Lymphoma of the urinary bladder","volume":"236","author":"House","year":"2010","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Greci, V., Rocchi, P.M., Sontuoso, A.F., Olivero, D., Capasso, A., and Raiano, V. (2017). Primary fibrosarcoma of the urinary bladder in a cat: Follow-up after incomplete surgical excision. JFMS Open Rep., 3.","DOI":"10.1177\/2055116917714881"},{"key":"ref_8","first-page":"381","article-title":"Intravenous leiomyoma of the bladder in a cat","volume":"175","author":"Patnaik","year":"1979","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_9","first-page":"749","article-title":"Leiomyosarcoma of the urinary bladder in a cat","volume":"167","author":"Burk","year":"1975","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1590\/0103-8478cr20140686","article-title":"Clinicopathological and immunohistochemical evaluation of oesophageal leiomyosarcoma in a dog","volume":"45","author":"Alves","year":"2015","journal-title":"Ci\u00eanc. Rural."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-3-0348-0837-8_8","article-title":"The role of inflammation in bladder cancer","volume":"816","author":"Gakis","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_12","first-page":"514","article-title":"Emphysematous cystitis: Retrospective evaluation of predisposing factors and ultrasound features in 36 dogs and 2 cats","volume":"60","author":"Lippi","year":"2019","journal-title":"Can. Vet. J."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Capasso, A., Raiano, V., Sontuoso, A., Olivero, D., and Greci, V. (2015). Fibrosarcoma of the urinary bladder in a cat. JFMS Open Rep., 1.","DOI":"10.1177\/2055116915585019"}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/6\/3\/60\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:01:37Z","timestamp":1760187697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/6\/3\/60"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,27]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["vetsci6030060"],"URL":"https:\/\/doi.org\/10.3390\/vetsci6030060","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,27]]}}}