{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T22:21:48Z","timestamp":1776810108573,"version":"3.51.2"},"reference-count":20,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T00:00:00Z","timestamp":1565827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["Project Grant PJT-148531"],"award-info":[{"award-number":["Project Grant PJT-148531"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Situs inversus totalis is a condition where there is a transposition of all internal organs from their normal anatomical location. This infrequent and rare congenital condition has been described in several species of mammals. Dextorcardia is a series of conditions associated with an abnormal congenital positioning of the heart, and is often associated with situs inversus totalis. Here we report a case of situs inversus totalis and two cases of dextrocardia identified in Sprague Dawley rats during gross necropsy evaluations at both the Health Sciences North Research Institute (HSNRI) in Canada and Finlay Institute of Vaccine Research and Production in Cuba. The intent of this report is to share our findings and aid in the accumulation of data on these rare conditions.<\/jats:p>","DOI":"10.3390\/vetsci6030067","type":"journal-article","created":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T04:22:54Z","timestamp":1565842974000},"page":"67","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Reports of Situs Inversus Totalis and Dextrocardia in Sprague Dawley Rats"],"prefix":"10.3390","volume":"6","author":[{"given":"Reynaldo Oliva","family":"Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Finlay Institute of Vaccine Research and Production, Havana 11600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan D.","family":"Lewicky","sequence":"additional","affiliation":[{"name":"Health Sciences North Research Institute (HSNRI), Sudbury, ON P3E2H3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nya L.","family":"Fraleigh","sequence":"additional","affiliation":[{"name":"Health Sciences North Research Institute (HSNRI), Sudbury, ON P3E2H3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoang-Thanh","family":"Le","sequence":"additional","affiliation":[{"name":"Health Sciences North Research Institute (HSNRI), Sudbury, ON P3E2H3, Canada"},{"name":"Northern Ontario School of Medicine (NOSM), Sudbury, ON P3E2C6, Canada"},{"name":"Chemistry &amp; Biochemistry and Biology Departments, Laurentian University, Sudbury, ON P3E2C6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e0205","DOI":"10.1097\/MD.0000000000010205","article-title":"Situs inversus totalis with solid pseudopapillary pancreatic tumor","volume":"97","author":"Xiang","year":"2018","journal-title":"Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/1477-7819-11-312","article-title":"Pancreaticoduodenectomy for biliary tract carcinoma with situs inversus totalis: Difficulties and technical notes based on two cases","volume":"11","author":"Kyuno","year":"2013","journal-title":"World. 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Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"228","DOI":"10.15210\/sah.v4i3.8098","article-title":"Situs inversus totalis EM RATO WISTAR","volume":"4","author":"Carnevali","year":"2016","journal-title":"Sci. Anim. Health"},{"key":"ref_20","first-page":"1","article-title":"Valores hematol\u00f3gicos y bioqu\u00edmicos de las ratas Sprague Dawley producidas en el CENPALAB, Cenp: SPRD","volume":"12","author":"Blanco","year":"2011","journal-title":"REDVET"}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/6\/3\/67\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:11:12Z","timestamp":1760188272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/6\/3\/67"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,15]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["vetsci6030067"],"URL":"https:\/\/doi.org\/10.3390\/vetsci6030067","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,15]]}}}