{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:14:31Z","timestamp":1787030071250,"version":"build-2736575974"},"reference-count":28,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>In recent years, degus (Octodon degus), rodents native to South America, have been becoming increasingly popular as pet animals. Data about neoplastic diseases in this species are still sparse and mainly limited to single-case reports. The aim of this study was to present neoplastic and non-neoplastic proliferative changes in 16\/100 pet degus examined at the Veterinary Faculty University of Ljubljana from 2010 to 2015 and to describe the clinic-pathological features of these lesions. Twenty different lesions of the integumentary, musculoskeletal, genitourinary and gastrointestinal systems were diagnosed: amongst these were 13 malignant tumors, six benign tumors, and one non-neoplastic lesion. Cutaneous fibrosarcoma was the most common tumor (7\/16 degus). It was detected more often in females (6\/7 degus) and lesions were located mainly in hind limbs. The gastrointestinal tract was frequently affected, namely with two malignant neoplasms - an intestinal lymphoma and a mesenteric mesothelioma, four benign tumors \u2013 two biliary cystadenomas, an oral squamous papilloma and a hepatocellular adenoma, and a single non-neoplastic proliferative lesion. In one animal, two organic systems were involved in neoplastic lesions.<\/jats:p>","DOI":"10.3390\/vetsci7010032","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T08:13:27Z","timestamp":1584519207000},"page":"32","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Spontaneous Tumors and Non-Neoplastic Proliferative Lesions in Pet Degus (Octodon degus)"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5469-9273","authenticated-orcid":false,"given":"Tanja","family":"\u0160vara","sequence":"first","affiliation":[{"name":"Institute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, SI-1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitja","family":"Gomba\u010d","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, SI-1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Poli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u017eko","family":"Ra\u010dnik","sequence":"additional","affiliation":[{"name":"Clinic for Birds, Small mammals and Reptiles, Institute of Poultry, Birds, Small Mammals and Reptiles, Veterinary Faculty, University of Ljubljana, SI-1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Zadravec","sequence":"additional","affiliation":[{"name":"Clinic for Birds, Small mammals and Reptiles, Institute of Poultry, Birds, Small Mammals and Reptiles, Veterinary Faculty, University of Ljubljana, SI-1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"ref_1","unstructured":"Nowak, R.M. (1999). Walker\u2019s Mammals of the World, The Johns Hopkins University Press. [6th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/dev.10096","article-title":"Influence of parental deprivation on the behavioral development in Octodon degus: Modulation by maternal vocalizations","volume":"42","author":"Braun","year":"2003","journal-title":"Dev. Psychobiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/molbev\/msi117","article-title":"Adaptive evolution of the insulin gene in caviomorph rodents","volume":"22","author":"Opazo","year":"2005","journal-title":"Mol. Biol. Evol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pharmthera.2018.03.001","article-title":"The long-lived Octodon degus as a rodent drug discovery model for Alzheimer\u2019s and other age-related diseases","volume":"188","author":"Hurley","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1748-5827.2010.01028.x","article-title":"Diseases in pet degus: A retrospective study in 300 animals","volume":"52","author":"Jekl","year":"2011","journal-title":"J. Small. Anim. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.7589\/0090-3558-26.1.129","article-title":"Bronchioalveolar carcinoma with renal and hepatic metastases in a degu (Octodon degus)","volume":"26","author":"Anderson","year":"1990","journal-title":"J. Wildl. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1556\/avet.58.2010.3.6","article-title":"Claudin-5-positive angioleiomyoma in the uterus of a degu (Octodon degus)","volume":"58","author":"Jakab","year":"2010","journal-title":"Acta Vet. Hung."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1177\/089875641202900304","article-title":"Common dental disorders of the degu (Octodon degus)","volume":"29","author":"Long","year":"2012","journal-title":"J. Vet. Dent."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1053\/j.jepm.2008.04.001","article-title":"Elodontoma in a Degu (Octodon degus)","volume":"17","author":"Jekl","year":"2008","journal-title":"J. Exot. Pet. Med."},{"key":"ref_10","first-page":"41","article-title":"Renal transitional cell carcinoma and choristoma in a degu (Octodon degus)","volume":"44","author":"Lester","year":"2005","journal-title":"Contemp. Top. Lab. Anim. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1177\/1040638718814584","article-title":"Coccygeal chordoma in a degu: Case report and review of the literature","volume":"31","author":"Sautier","year":"2019","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.17221\/2960-VETMED","article-title":"Vaginal leiomyosarcoma in a degu (Octodon degus): A case report","volume":"55","author":"Skoric","year":"2010","journal-title":"Vet. Med."},{"key":"ref_13","first-page":"4","article-title":"Parathyroid adenocarcinoma with metastasis and pulmonary adenocarcinoma in a degu (Octodon degus)","volume":"39","author":"Smith","year":"2000","journal-title":"Contemp. Top. Lab. Anim. Sci."},{"key":"ref_14","unstructured":"Montali, R.J., and Migaki, G. (1980). Spontaneous lesions in the degu. Comparative Pathology of Zoo Animals, Smithsonian Institution Press."},{"key":"ref_15","unstructured":"Goldschmidt, M.H., Dunstan, R.W., Stannard, A.A., von Tscharneer, C., Walder, E.J., and Yager, J.A. (1998). Histological Classification of Epithelial and Melanocytic Tumors of the Skin of Domestic Animals, Armed Force Institute of Pathology."},{"key":"ref_16","unstructured":"Kennedy, P.C., Cullen, J.M., Edwards, J.F., Goldschmidt, M.H., Larsen, S., Munson, L., and Nielsen, S. (1998). Histological Classification of Tumors of the Genital System of Domestic Animals, Armed Force Institute of Pathology."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Head, K.W., Cullen, J.M., Dubielzig, R.R., Else, R.W., Misdorp, W., Patnaik, A.K., Tateyama, S., and van der Gaag, I. (2003). Histological Classification of Tumors of the Alimentary System of Domestic Animals, Armed Force Institute of Pathology.","DOI":"10.1002\/9780470376928.ch8"},{"key":"ref_18","unstructured":"Meuten, D.J., Everitt, J., Inskeep, W., Jacobs, R.M., Peleteiro, M., and Thompson, K.G. (2004). Histological Classification of Tumors of the Urinary System of Domestic Animals, Armed Force Institute of Pathology."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/0300985810388820","article-title":"Prognostic factors for cutaneous and subcutaneous soft tissue sarcomas in dogs","volume":"48","author":"Dennis","year":"2011","journal-title":"Vet. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1354\/vp.42-1-77","article-title":"Invasive epithelial mesothelioma in a dog","volume":"42","author":"Reggetti","year":"2005","journal-title":"Vet Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1530\/jrf.0.0660031","article-title":"Embryonic development of the degu, Octodon degus","volume":"66","author":"Rojas","year":"1982","journal-title":"J. Reprod. Fertil."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"10660","DOI":"10.1038\/s41598-017-10333-x","article-title":"Germline Mutations in Cancer Predisposition Genes are Frequent in Sporadic Sarcomas","volume":"7","author":"Chan","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"18607","DOI":"10.18632\/oncotarget.24719","article-title":"Genetic susceptibility to bone and soft tissue sarcomas: A field synopsis and meta-analysis","volume":"9","author":"Benna","year":"2018","journal-title":"Oncotarget"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Meuten, D.J. (2016). Tumors in Domestic Animals, John Wiley & Sons, Inc.. [5th ed.].","DOI":"10.1002\/9781119181200"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/030098589102800602","article-title":"A histomorphologic and immunohistochemical study of chordoma in twenty ferrets (Mustela putorius furo)","volume":"28","author":"Dunn","year":"1991","journal-title":"Vet. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/030098588802500106","article-title":"Chordomas in Fischer 344 rats","volume":"25","author":"Stefanski","year":"1988","journal-title":"Vet. Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.cvex.2016.11.015","article-title":"Reproductive disorders in pet rodents","volume":"20","author":"Marttorell","year":"2017","journal-title":"Vet. Clin. North Am. Exot. Anim. Pract."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cvex.2016.11.014","article-title":"Reproductive medicine in guinea pigs, chinchillas and degus","volume":"20","author":"Kondert","year":"2017","journal-title":"Vet. Clin. North Am. Exot. Anim. Pract."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/7\/1\/32\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:06:45Z","timestamp":1760173605000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/7\/1\/32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,13]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,3]]}},"alternative-id":["vetsci7010032"],"URL":"https:\/\/doi.org\/10.3390\/vetsci7010032","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,13]]}}}