{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T20:18:19Z","timestamp":1770668299622,"version":"3.49.0"},"reference-count":27,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>The literature is lacking data concerning the prognosis in cats suffering from naturally occurring acute onset of thoracolumbar (TL) spinal cord injury that are undergoing rehabilitation therapy. Therefore, we investigated the effect of physical rehabilitation in cats suffering from naturally occurring TL spinal cord injury. The medical records of 36 cats with acute onset of TL spinal cord injury that were selected for rehabilitation treatment were reviewed. Twenty-nine cats underwent an intensive physical rehabilitation protocol in the clinic (group 1), whereas the owners of seven cats declined physical rehabilitation (group 2). In group 1, seven cats had pelvic limb deep pain perception (DPP), which was significantly associated with the functional recovery of voluntary ambulatory status (p = 0.010) and voluntary micturition (p &lt; 0.001). Spinal walking was achieved in 10\/22 (45%) of the cats without DPP, and none regained voluntary micturition. In group 2, no cats regained ambulatory status or voluntary micturition, although pelvic limb DPP was present in three patients. Treatment with a clinic-based rehabilitation program and the presence of a crossed extensor reflex were significantly associated with a higher possibility of regaining functional ambulatory status (p &lt; 0.010), but there was no difference in the recovery of voluntary micturition between the groups. Thus, cats with severe, naturally occurring, acute onset of TL spinal cord injury may benefit from physical rehabilitation. In the case of the loss of DPP, the acquisition of spinal walking is possible, despite the high possibility of a persistent neurologically dysfunctional bladder.<\/jats:p>","DOI":"10.3390\/vetsci8020022","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T05:53:43Z","timestamp":1611899623000},"page":"22","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Outcome in Cats with Acute Onset of Severe Thoracolumbar Spinal Cord Injury Following Physical Rehabilitation"],"prefix":"10.3390","volume":"8","author":[{"given":"Antonella","family":"Gallucci","sequence":"first","affiliation":[{"name":"Neurology Service, La Fenice Veterinary Center, 09032 Assemini, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovica","family":"Dragone","sequence":"additional","affiliation":[{"name":"Physiotherapy and Rehabilitation Center \u201cDog Fitness,\u201d 42124 Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Al Kafaji","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marika","family":"Menchetti","sequence":"additional","affiliation":[{"name":"Neurology and Neurosurgery Division, San Marco Veterinary Clinic, 35030 Veggiano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Del Magno","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9247-7110","authenticated-orcid":false,"given":"Gualtiero","family":"Gandini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cvsm.2014.09.010","article-title":"Feline Rehabilitation","volume":"45","author":"Drum","year":"2015","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1748-5827.2012.01242.x","article-title":"Low-level laser therapy reduces time to ambulation in dogs after hemilaminectomy: A preliminary study","volume":"53","author":"Draper","year":"2012","journal-title":"J. Small Anim. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.5897\/JVMAH2015.0398","article-title":"Recovery times for dogs undergoing thoracolumbar hemilaminectomy with fenestration and physical rehabilitation: A review of 113 cases","volume":"7","author":"Hady","year":"2015","journal-title":"J. Vet. Med. Anim. Health"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2460\/ajvr.78.2.195","article-title":"Preliminary evaluation of the effects of photobiomodulation therapy and physical rehabilitation on early postoperative recovery of dogs undergoing hemilaminectomy for treatment of thoracolumbar intervertebral disk disease","volume":"78","author":"Bennaim","year":"2017","journal-title":"Am. J. Vet. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/jvim.14651","article-title":"Acquisition of Involuntary Spinal Locomotion (Spinal Walking) in Dogs with Irreversible Thoracolumbar Spinal Cord Lesion: 81 Dogs","volume":"31","author":"Gallucci","year":"2017","journal-title":"J. Vet. Intern. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/jvim.15086","article-title":"A randomized, blinded, prospective clinical trial of postoperative rehabilitation in dogs after surgical decompression of acute thoracolumbar intervertebral disc herniation","volume":"32","author":"Zidan","year":"2018","journal-title":"J. Vet. Intern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0014-4886(86)90094-4","article-title":"Effects of training on the recovery of full-weight-bearing stepping in the adult spinal cat","volume":"92","author":"Lovely","year":"1986","journal-title":"Exp. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1152\/jn.1998.79.3.1329","article-title":"Locomotor Capacity Attributable to Step Training Versus Spontaneous Recovery After Spinalization in Adult Cats","volume":"79","author":"Hodgson","year":"1998","journal-title":"J. Neurophysiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1089\/neu.2011.2199","article-title":"A Systematic Review of Exercise Training to Promote Locomotor Recovery in Animal Models of Spinal Cord Injury","volume":"29","author":"Battistuzzo","year":"2012","journal-title":"J. Neurotrauma"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.neuro.27.070203.144308","article-title":"Plasticity of the Spinal Neural Circuitry After Injury","volume":"27","author":"Edgerton","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.neuro.29.051605.112910","article-title":"Locomotor Circuits in the Mammalian Spinal Cord","volume":"29","author":"Kiehn","year":"2006","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3389\/fvets.2020.00560","article-title":"Canine Spinal Cord Injury Consortium (CANSORT-SCI). Ambulation in Dogs with Absent Pain Perception after Acute Thoracolumbar Spinal Cord Injury","volume":"7","author":"Lewis","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.2460\/ajvr.2001.62.1624","article-title":"Development of a functional scoring system in dogs with acute spinal cord injuries","volume":"62","author":"Olby","year":"2001","journal-title":"Am. J. Vet. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2460\/javma.2003.222.762","article-title":"Long-term functional outcome of dogs with severe injuries of the thoracolumbar spinal cord: 87 cases (1996\u20132001)","volume":"222","author":"Olby","year":"2003","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2460\/javma.253.2.196","article-title":"Relationship of preoperative neurologic score with intervals to regaining micturition and ambulation following surgical treatment of thoracolumbar disk herniation in dogs","volume":"253","author":"Skytte","year":"2018","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1748-5827.2004.tb00236.x","article-title":"Survival Rates and Outcomes in Cats with Thoracic and Lumbar Spinal Cord Injuries Due to External Trauma","volume":"45","author":"Grasmueck","year":"2004","journal-title":"J. Small Anim. Pract."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.jfms.2011.09.006","article-title":"Acute spinal cord injury in the cat. Causes, treatment and prognosis","volume":"13","author":"Eminaga","year":"2011","journal-title":"J. Feline Med. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1748-5827.1997.tb03303.x","article-title":"Hemilaminectomy for the treatment of thoracolumbar disc disease in the dog: A follow-up study of 40 cases","volume":"38","author":"Scott","year":"1997","journal-title":"J. Small Anim. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1748-5827.1999.tb03114.x","article-title":"Laminectomy for 34 dogs with thoracolumbar intervertebral disc disease and loss of deep pain perception","volume":"40","author":"Scott","year":"1999","journal-title":"J. Small Anim. Pract."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1055\/s-0038-1632970","article-title":"Outcome and prognostic factors in non-ambulatory Hansen type I intervertebral disc extrusions: 308 cases","volume":"19","author":"Ruddle","year":"2006","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2460\/javma.248.4.386","article-title":"Factors associated with recovery from paraplegia in dogs with loss of pain perception in the pelvic limbs following intervertebral disk herniation","volume":"248","author":"Jeffery","year":"2016","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1523\/JNEUROSCI.5692-07.2008","article-title":"Prominent Role of the Spinal Central Pattern Generator in the Recovery of Locomotion after Partial Spinal Cord Injuries","volume":"28","author":"Leblond","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S0959-4388(00)00151-3","article-title":"Locomotion and its recovery after spinal injury","volume":"10","author":"Rossignol","year":"2000","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"384","DOI":"10.5326\/15473317-37-4-384","article-title":"Intervertebral disk disease in 10 cats","volume":"37","author":"Olby","year":"2001","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jfms.2008.05.001","article-title":"Clinical and Magnetic Resonance Imaging Findings in 92 Cats with Clinical Signs of Spinal Cord Disease","volume":"11","author":"Platt","year":"2009","journal-title":"J. Feline Med. Surg."},{"key":"ref_26","first-page":"1445","article-title":"Preliminary investigation of the feline intervertebral disc. Proceedings of the 27th Symposium ESVN-ECVN","volume":"29","author":"Smolders","year":"2015","journal-title":"J. Vet. Int. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1177\/1098612X12458209","article-title":"Feline Physiotherapy and Rehabilitation: 1. Principles and potential","volume":"14","author":"Sharp","year":"2012","journal-title":"J. Feline Med. Surg."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/8\/2\/22\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:17:00Z","timestamp":1760159820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/8\/2\/22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,29]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["vetsci8020022"],"URL":"https:\/\/doi.org\/10.3390\/vetsci8020022","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,29]]}}}