{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:15:45Z","timestamp":1787030145933,"version":"build-2736575974"},"reference-count":52,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T00:00:00Z","timestamp":1626480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BAYRISCHE Forschungsstiftung within the Forschungsverbund Tumordiagnostik f\u00fcr individualisierte Therapie \u2013 FORTiTher, TP-4.","award":["AZ-1365-18"],"award-info":[{"award-number":["AZ-1365-18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Breed predispositions to canine digital neoplasms are well known. However, there is currently no statistical analysis identifying the least affected breeds. To this end, 2912 canine amputated digits submitted from 2014\u20132019 to the Laboklin GmbH &amp; Co. KG for routine diagnostics were statistically analyzed. The study population consisted of 155 different breeds (most common: 634 Mongrels, 411 Schnauzers, 197 Labrador Retrievers, 93 Golden Retrievers). Non-neoplastic processes were present in 1246 (43%), tumor-like lesions in 138 (5%), and neoplasms in 1528 cases (52%). Benign tumors (n = 335) were characterized by 217 subungual keratoacanthomas, 36 histiocytomas, 35 plasmacytomas, 16 papillomas, 12 melanocytomas, 9 sebaceous gland tumors, 6 lipomas, and 4 bone tumors. Malignant neoplasms (n = 1193) included 758 squamous cell carcinomas (SCC), 196 malignant melanomas (MM), 76 soft tissue sarcomas, 52 mast cell tumors, 37 non-specified sarcomas, 29 anaplastic neoplasms, 24 carcinomas, 20 bone tumors, and 1 histiocytic sarcoma. Predisposed breeds for SCC included the Schnauzer (log OR = 2.61), Briard (log OR = 1.78), Rottweiler (log OR = 1.54), Poodle (log OR = 1.40), and Dachshund (log OR = 1.30). Jack Russell Terriers (log OR = \u22122.95) were significantly less affected by SCC than Mongrels. Acral MM were significantly more frequent in Rottweilers (log OR = 1.88) and Labrador Retrievers (log OR = 1.09). In contrast, Dachshunds (log OR = \u22122.17), Jack Russell Terriers (log OR = \u22121.88), and Rhodesian Ridgebacks (log OR = \u22121.88) were rarely affected. This contrasted with the well-known predisposition of Dachshunds and Rhodesian Ridgebacks to oral and cutaneous melanocytic neoplasms. Further studies are needed to explain the underlying reasons for breed predisposition or \u201cresistance\u201d to the development of specific acral tumors and\/or other sites.<\/jats:p>","DOI":"10.3390\/vetsci8070136","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T21:18:52Z","timestamp":1626643132000},"page":"136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Digital Lesions in Dogs: A Statistical Breed Analysis of 2912 Cases"],"prefix":"10.3390","volume":"8","author":[{"given":"Julia Maria","family":"Grassinger","sequence":"first","affiliation":[{"name":"Laboklin GmbH & Co. KG, 97688 Bad Kissingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Floren","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Tier\u00f6kologie und Tropenbiologie, Universit\u00e4t W\u00fcrzburg, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Bioinformatik, Universit\u00e4t W\u00fcrzburg, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argi\u00f1e","family":"Cerezo-Echevarria","sequence":"additional","affiliation":[{"name":"Laboklin GmbH & Co. KG, 97688 Bad Kissingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Beitzinger","sequence":"additional","affiliation":[{"name":"Laboklin GmbH & Co. KG, 97688 Bad Kissingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Conrad","sequence":"additional","affiliation":[{"name":"Laboklin GmbH & Co. KG, 97688 Bad Kissingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"T\u00f6rner","sequence":"additional","affiliation":[{"name":"Laboklin GmbH & Co. KG, 97688 Bad Kissingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Staudacher","sequence":"additional","affiliation":[{"name":"AniCura Aachen, Dres. Staudacher, 52078 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Aupperle-Lellbach","sequence":"additional","affiliation":[{"name":"Laboklin GmbH & Co. KG, 97688 Bad Kissingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1354\/vp.44-3-355","article-title":"Diagnoses and clinical outcomes associated with surgically amputated canine digits submitted to multiple veterinary diagnostic laboratories","volume":"44","author":"Wobeser","year":"2007","journal-title":"Vet. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1939-1676.2005.tb02751.x","article-title":"Canine Digital Tumors: A Veterinary Cooperative Oncology Group Retrospective Study of 64 Dogs","volume":"19","author":"Henry","year":"2005","journal-title":"J. Vet. Int. 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