{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T19:13:23Z","timestamp":1781982803946,"version":"3.54.5"},"reference-count":41,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Hyperlipidemia is a risk factor for nonalcoholic fatty liver disease (NAFLD) in humans. However, the association between serum lipids and canine chronic hepatitis remains unknown. In this study, serum lipids, hepatic profiles, and hepatic ultrasound scores of healthy dogs and dogs with chronic hepatitis were evaluated. Serum triglyceride and cholesterol concentrations were significantly higher (p &lt; 0.01) in dogs with chronic hepatitis. There were 62.2% of dogs with chronic hepatitis accompanied by hypertriglyceridemia, hypercholesterolemia, or both. Positive correlations were observed between serum ALT and cholesterol (r = 0.8287, p &lt; 0.01), serum ALP and cholesterol (r = 0.8436, p &lt; 0.01), serum GGT and cholesterol (r = 0.5640, p &lt; 0.01), serum bile acid and cholesterol (r = 0.3310, p &lt; 0.01) and serum ALP and triglycerides (r = 0.2582, p &lt; 0.05). No significant differences were found between ultrasound scores of diseased dogs with and without hypertriglyceridemia and diseased dogs with and without hypercholesterolemia. Canine chronic hepatitis is associated with hyperlipidemia. A significant positive association was identified between hyperlipidemia, especially hypercholesterolemia, liver enzymes, and bile acid concentration in dogs suffering from chronic hepatitis. The underlying mechanisms connecting hyperlipidemia and canine chronic hepatitis remain elusive.<\/jats:p>","DOI":"10.3390\/vetsci8100221","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:59:47Z","timestamp":1633917587000},"page":"221","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Changes in Serum Lipid Profiles among Canine Patients Suffering from Chronic Hepatitis"],"prefix":"10.3390","volume":"8","author":[{"given":"Sathidpak Nantasanti","family":"Assawarachan","sequence":"first","affiliation":[{"name":"Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, 50 Pahonyothin Rd., Lat Yao, Chatuchak, Bangkok 10900, Thailand"},{"name":"Endocrinology and Gastroenterology Unit, Kasetsart University Veterinary Teaching Hospital, 50 Pahonyothin Rd., Lat Yao, Chatuchak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyathip","family":"Chuchalermporn","sequence":"additional","affiliation":[{"name":"Radiology Unit, Kasetsart University Veterinary Teaching Hospital, 50 Pahonyothin Rd., Lat Yao, Chatuchak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phudit","family":"Maneesaay","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Kasetsart University, 50 Pahonyothin Rd., Lat Yao, Chatuchak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naris","family":"Thengchaisri","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, 50 Pahonyothin Rd., Lat Yao, Chatuchak, Bangkok 10900, Thailand"},{"name":"Tippimarn Veterinary Hospital, Chulabhorn Royal Academy, 906\/1 Pong Ta long Subdistrict, Pak Chong District, Nakohn Ratchasima 30130, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"key":"ref_1","first-page":"217","article-title":"A descriptive study of the histopathologic and biochemical liver test abnormalities in dogs with liver disease in Thailand","volume":"84","author":"Assawarachan","year":"2020","journal-title":"Can. 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