{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:46:18Z","timestamp":1792791978598,"version":"4.5.0"},"reference-count":36,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Ivermectin has a wide number of many diverse functions. Certainly, it is irreplaceable for the treatment of parasitic pathologies in both human and veterinary medicine, and the latter represents the major field of its application. It has been called the \u201cdrug for the world\u2019s poor\u201d because of its role as a saviour for those living on the margins of society, in underdeveloped areas afflicted by devastating and debilitating diseases, such as Onchocerciasis and Lymphatic filariasis. It showed huge, unexpected potential as an antibacterial (Chlamydia trachomatis and mycobacteria), and it has antiviral and anti-inflammatory properties. The research line described here is placed right in the middle of the investigation on the impact of this drug as an antimicrobial and an immunomodulator. Being a drug widely employed for mass administration, it is mandatory to broaden the knowledge of its possible interaction with bacterial growth and its generation of antimicrobial resistance. Equally, it is important to understand the impact of these drugs on the immune systems of animal species, e.g., horses and dogs, in which this drug is often used. More importantly, could immunomodulation and antibacterial activity promote both bacterial growth and the occurrence of resistance mechanisms?<\/jats:p>","DOI":"10.3390\/vetsci9010024","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T20:33:04Z","timestamp":1641933184000},"page":"24","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ivermectin (IVM) Possible Side Activities and Implications in Antimicrobial Resistance and Animal Welfare: The Authors\u2019 Perspective"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6109-0834","authenticated-orcid":false,"given":"Cristian","family":"Piras","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Campus Universitario \u201cS. Venuta\u201d, University \u201cMagna Gr\u00e6cia\u201d of Catanzaro, Viale Europa, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6840-3154","authenticated-orcid":false,"given":"Enrico","family":"Gugliandolo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9600-6401","authenticated-orcid":false,"given":"Fabio","family":"Castagna","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Campus Universitario \u201cS. Venuta\u201d, University \u201cMagna Gr\u00e6cia\u201d of Catanzaro, Viale Europa, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4199-207X","authenticated-orcid":false,"given":"Ernesto","family":"Palma","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Campus Universitario \u201cS. Venuta\u201d, University \u201cMagna Gr\u00e6cia\u201d of Catanzaro, Viale Europa, 88100 Catanzaro, Italy"},{"name":"Nutramed S.c.a.r.l. Complesso Nin\u00ec Barbieri, Roccelletta di Borgia, 88021 Catanzaro, Italy"},{"name":"Department of Health Sciences, Institute of Research for Food Safety & Health (IRC-FISH), University of Catanzaro Magna Gr\u00e6cia, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7355-8791","authenticated-orcid":false,"given":"Domenico","family":"Britti","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Campus Universitario \u201cS. Venuta\u201d, University \u201cMagna Gr\u00e6cia\u201d of Catanzaro, Viale Europa, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2183\/pjab.87.13","article-title":"Ivermectin,\u2018wonder drug\u2019from Japan: The human use perspective","volume":"87","author":"Crump","year":"2011","journal-title":"Proc. Japan Acad. Ser. B"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ja.2017.11","article-title":"Ivermectin: Enigmatic multifaceted \u2018wonder\u2019drug continues to surprise and exceed expectations","volume":"70","author":"Crump","year":"2017","journal-title":"J. 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