{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:43:03Z","timestamp":1787679783399,"version":"build-2784847793"},"reference-count":120,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T00:00:00Z","timestamp":1642809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Pigeon racing is a sport in which trained homing pigeons (Columba livia domestica) are released between 60 and 1200 km from their loft and then have to return home as quickly as possible. The first race was held in 1818 in Belgium and since then, Belgium has led the world in pigeon breeding. Unfortunately, as in other sports, doping has become a major issue and doping controls have been implemented. This review provides information about pigeon racing, rules from the Royal Federation Colombophile of Belgium, and laws applicable in Belgium as doping control issues cannot be understood without including them as part of pigeon racing. The main pharmacological data concerning corticoids, non-steroidal anti-inflammatory drugs, anabolic steroids, pain relievers and narcotic analgesics, bronchodilators and \u03b2-agonists, drugs acting on the central nervous system and other performance-enhancing drugs, in addition to methods relevant to doping in pigeons are presented. Moreover, the chosen matrix and analytical methods are described.<\/jats:p>","DOI":"10.3390\/vetsci9020042","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T20:36:27Z","timestamp":1642970187000},"page":"42","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Doping in Racing Pigeons (Columba livia domestica): A Review and Actual Situation in Belgium, a Leading Country in This Field"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2790-8006","authenticated-orcid":false,"given":"Didier","family":"Marlier","sequence":"first","affiliation":[{"name":"Bird, Rabbit and Rodent Clinic, Faculty of Veterinary Medicine, University of Liege, B4000 Liege, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/ptr.1337","article-title":"Ephedra in perspective\u2014A current review","volume":"17","author":"Abourashed","year":"2003","journal-title":"Phyther. Res."},{"key":"ref_2","first-page":"1","article-title":"History of doping and doping control","volume":"Volume 195","author":"Thieme","year":"2010","journal-title":"Doping in Sports: Biochemical Principles, Effects and Analysis"},{"key":"ref_3","unstructured":"Vindevogel, H., Duchatel, J.-P., and Pastoret, P.-P. (1998). Le Pigeon Voyageur, Editions du Point V\u00e9t\u00e9rinaire."},{"key":"ref_4","unstructured":"(2021, October 14). SPW Bien-Etre Animal Le Bien-Etre Animal en Wallonie. Available online: http:\/\/bienetreanimal.wallonie.be\/home\/legislation.html."},{"key":"ref_5","unstructured":"(2021, October 14). KBDB-RFCB Les R\u00e8glements et Statuts. Available online: www.kbdb.be\/fr\/les-reglements-et-statuts\/."},{"key":"ref_6","unstructured":"Gill, F., Donsker, D., and Rasmussen, P. (2021, October 10). IOC World Bird List (v11.2). Available online: https:\/\/www.worldbirdnames.org\/new\/."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.cub.2011.12.045","article-title":"Divergence, convergence, and the ancestry of feral populations in the domestic rock pigeon","volume":"22","author":"Stringham","year":"2012","journal-title":"Curr. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9971","DOI":"10.1073\/pnas.0901586106","article-title":"From wild animals to domestic pets, an evolutionary view of domestication","volume":"106","author":"Driscoll","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Smith, C. (2014). Pigeons: Domestication. Encyclopedia of Global Archaeology, Springer.","DOI":"10.1007\/978-1-4419-0465-2"},{"key":"ref_10","unstructured":"Levi, W. (1977). The Pigeon, Levi Publishing Co."},{"key":"ref_11","unstructured":"(2021, October 14). World Flexagon KFT FCI\u2014Home. Available online: https:\/\/pigeonsfci.org\/."},{"key":"ref_12","unstructured":"(2021, October 21). World Flexagon KFT FCI Membership. Available online: https:\/\/pigeonsfci.org\/membership\/."},{"key":"ref_13","unstructured":"(2021, November 19). KBDB-RFCB Lossingen in Beeld. Available online: https:\/\/www.kbdb.be\/fr\/lachers-video\/."},{"key":"ref_14","unstructured":"(2021, October 14). KBDB-RFCB Bureau D\u2019Enlogements. Available online: https:\/\/www.kbdb.be\/fr\/bureaux-denlogement\/."},{"key":"ref_15","unstructured":"(2021, October 14). KBDB-RFCB Home. Available online: https:\/\/www.kbdb.be\/fr\/591-2\/."},{"key":"ref_16","unstructured":"Laurence, J.C. (2021, October 21). Quand les Pigeons Valent des Millions. Available online: https:\/\/www.lapresse.ca\/international\/europe\/2021-04-10\/la-presse-en-belgique\/quand-les-pigeons-valent-des-millions.php."},{"key":"ref_17","unstructured":"Verbist, A. (2021, December 12). Les Pigeons Belges S\u2019envolent \u00e0 Prix d\u2019or Pour la Chine. Available online: https:\/\/www.lavenir.net\/cnt\/dmf20120303_00126177."},{"key":"ref_18","unstructured":"Fran\u00e7ois, A. (2021, December 12). Le Pigeon le Plus Cher du Monde Vient de Flandre Occidentale. Available online: https:\/\/www.vrt.be\/vrtnws\/fr\/2019\/03\/17\/le-pigeon-le-plus-cher-au-monde-vient-de-flandre-occidentale\/."},{"key":"ref_19","unstructured":"Carbonaro, J. (2021, December 13). The World\u2019s Most Expensive Pigeon is a Belgian Racing Bird Worth $1.8m. Available online: https:\/\/newseu.cgtn.com\/news\/2020-11-16\/The-world-s-most-expensive-pigeon-is-a-Belgian-racing-bird-worth-1-8m-VrxdRtr44w\/index.html."},{"key":"ref_20","unstructured":"Dupont, G. (2021, December 12). Le Pigeon Voyageur le Plus Cher de L\u2019histoire est Belge: New Kim Vendu 1 600 000 Euros!. Available online: https:\/\/www.lalibre.be\/belgique\/societe\/2020\/11\/15\/le-pigeon-voyageur-le-plus-cher-de-lhistoire-est-belge-new-kim-vendu-1-600-000-euros-EKRO2DSLZJGNRPQLOZAYWOEEJY\/."},{"key":"ref_21","unstructured":"(2021, October 20). Anonymous Belgique: Un Pigeon Vendu 1,6 Million D\u2019Euros, un Record. Available online: https:\/\/www.20minutes.fr\/monde\/2908895-20201115-belgique-pigeon-voyageur-vendu-16-million-euro-record."},{"key":"ref_22","unstructured":"(2021, December 12). Anonymous Jales Huang Wins Ace Pigeon Pioneer Club\u2014Pigeon Sold for World Record of 2.78 Million Euros!. Available online: https:\/\/www.deduif.be\/nl\/nieuws\/james-huang-wins-ace-pigeon-pioneer-club-pigeon-sold-world-record-278-million-euros."},{"key":"ref_23","unstructured":"(2021, December 12). PIPA Trading BV PIPA Milestones. Available online: https:\/\/www.pipa.be\/fr\/pipa-milestones."},{"key":"ref_24","unstructured":"(2021, October 14). KBDB-RFCB Liste des Laboratoires Reconnus. Available online: www.kbdb.be\/fr\/doping-labo-2\/."},{"key":"ref_25","unstructured":"(2021, October 14). KBDB-RFCB Liste Rouge. Available online: https:\/\/www.kbdb.be\/images\/RED%20LIST%202018%20Fran%C3%A7ais.pdf."},{"key":"ref_26","unstructured":"(2021, December 12). AFSCA-FAVV Circulaire Relaitve \u00e0 L\u2019Introduction des Pigeons Dans la Cha\u00eene Climentaire. Available online: www.favv-afsca.be\/professionnels\/productionanimale\/animaux\/circulaires\/_documents\/2015_06_15_FR_circ-ob_pigeons_v1.pdf."},{"key":"ref_27","unstructured":"(2021, December 12). Vlaams Parlement Gemeenschaps-En Gewestregeringen Gouvernements de Communaute et de Region Gemeinschafts- und regionalregierungen. Available online: http:\/\/www4wvg.vlaanderen.be\/wvg\/ijh\/vlaanderen\/documentenregelgeving\/20130913_Decemberreet_staatsblad.pdf."},{"key":"ref_28","unstructured":"(2021, December 12). International Pigeon Racing Federation Anti-Doping Control. Available online: https:\/\/pigeonsfci.org\/wp-content\/uploads\/2020\/04\/Anti-Doping-Control-EN.pdf."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jchromb.2018.05.004","article-title":"Quantification of doping compounds in faecal samples from racing pigeons, by liquid chromatography-tandem mass spectrometry","volume":"1089","author":"Moreira","year":"2018","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_30","first-page":"344","article-title":"Detection of doping compounds in the racing pigeon","volume":"109","author":"Hagedorn","year":"1996","journal-title":"Berl. Munch. Tierarztl. Wochenschr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2460\/ajvr.1997.58.03.224","article-title":"Excretion of the anabolic steroid boldenone by racing pigeons","volume":"58","author":"Hagedorn","year":"1997","journal-title":"Am. J. Vet. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/jat\/bky088","article-title":"The use of feathers from racing pigeons for doping control purposes","volume":"43","author":"Moreira","year":"2019","journal-title":"J. Anal. Toxicol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/dta.2999","article-title":"Doping detection in animals: A review of analytical methodologies published from 1990 to 2019","volume":"13","author":"Moreira","year":"2021","journal-title":"Drug Test. Anal."},{"key":"ref_34","first-page":"883","article-title":"The potential role of oral fluid in antidoping testing","volume":"17","author":"Huestis","year":"2012","journal-title":"Nat. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/03079458808436440","article-title":"Collection and analysis of urine from racing pigeons (Columba livia domestica)","volume":"17","author":"Halsema","year":"1987","journal-title":"Avian Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/jms.542","article-title":"Liquid chromatography\/electrospray ionization tandem mass spectrometric screening and confirmation methods for \u03b22-agonists in human or equine urine","volume":"38","author":"Thevis","year":"2003","journal-title":"J. Mass Spectrom."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.trac.2010.07.012","article-title":"Screening in veterinary drug analysis and sports doping control based on full-scan, accurate-mass spectrometry","volume":"29","author":"Peters","year":"2010","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1016\/j.chroma.2009.11.001","article-title":"Fast analysis of doping agents in urine by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry. II: Confirmatory analysis","volume":"1217","author":"Badoud","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1016\/j.chroma.2009.03.033","article-title":"Fast analysis of doping agents in urine by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry. I: Screening analysis","volume":"1216","author":"Badoud","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"122551","DOI":"10.1016\/j.jchromb.2021.122551","article-title":"Doping control analysis of small peptides: A Decemberade of progress","volume":"1173","author":"Esposito","year":"2021","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.aca.2018.05.016","article-title":"Development and validation of a multidimensional gas chromatography\/combustion\/isotope ratio mass spectrometry-based test method for analyzing urinary steroids in doping controls","volume":"1030","author":"Putz","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"113807","DOI":"10.1016\/j.jpba.2020.113807","article-title":"Improving the detection of anabolic steroid esters in human serum by LC\u2013MS","volume":"194","author":"Iannone","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s00216-012-5726-z","article-title":"Current use of high-resolution mass spectrometry in drug screening relevant to clinical and forensic toxicology and doping control","volume":"403","author":"Kolmonen","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"114280","DOI":"10.1016\/j.jpba.2021.114280","article-title":"Steroid profiling by UHPLC-MS\/MS in dried blood spots collected from healthy women with and without testosterone gel administration","volume":"204","author":"Salamin","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jchromb.2013.10.008","article-title":"A generic screening methodology for horse doping control by LC-TOF-MS, GC-HRMS and GC-MS","volume":"941","author":"Kioussi","year":"2013","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jpba.2018.05.043","article-title":"Doping control analysis of 121 prohibited substances in equine hair by liquid chromatography\u2013tandem mass spectrometry","volume":"158","author":"Wong","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tvjl.2014.01.006","article-title":"Doping control analyses in horseracing: A clinician\u2019s guide","volume":"200","author":"Wong","year":"2014","journal-title":"Vet. J."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Thieme, D., and Hemmersbach, P. (2010). Doping in Sports Biochemical Principles, Effects and Analysis, Springer.","DOI":"10.1007\/978-3-540-79088-4"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/elps.201600509","article-title":"Evaluation of various approaches to the isolation of steroid hormones from urine samples prior to FASS-MEKC analysis","volume":"38","author":"Kowalski","year":"2017","journal-title":"Electrophoresis"},{"key":"ref_50","unstructured":"(2021, December 13). International Equestrian Federation FEI Standards for Laboratories. Available online: https:\/\/www.google.com.tw\/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwiJiJDp8sn1AhUnSGwGHbhiBskQFnoECAgQAQ&url=https%3A%2F%2Finside.fei.org%2Fsystem%2Ffiles%2FFEI%2520Standard%2520for%2520Laboratories%2520-%2520December%25202017_0.pdf&usg=AOvVaw3fE3Rxn84CAZPh38Xv_C9B."},{"key":"ref_51","unstructured":"(2021, December 13). World Anti-Doping Agency Accreditation Process. Available online: www.wada-ama.org\/en\/what-we-do\/science-medical\/laboratories\/accreditation-process."},{"key":"ref_52","unstructured":"(2021, December 13). International Equestrian Federation Anti-Doping Rules. Available online: https:\/\/inside.fei.org\/content\/anti-doping-rules."},{"key":"ref_53","unstructured":"(2021, December 13). World Anti-Doping Agency International Standard for Laboratories. Available online: https:\/\/www.wada-ama.org\/en\/resources\/laboratories\/international-standard-for-laboratories-isl."},{"key":"ref_54","unstructured":"(2021, December 12). World Anti-Doping Agency Guidelines for Harmonization of Scopes of iISO\/IEC 17025 Accreditation of WADA Anti-Doping Laboratroies. Available online: https:\/\/www.wada-ama.org\/en\/resources\/science-medicine\/guidelines-for-harmonization-of-scopes-of-isoiec-17025-accreditation-of."},{"key":"ref_55","first-page":"55","article-title":"Nonsteroidal anti-inflammatory drugs in birds: Pharmacokinetics, pharmacodynamics and toxicity","volume":"85","author":"Goessens","year":"2016","journal-title":"Vlaams Diergeneeskd. Tijdschr."},{"key":"ref_56","first-page":"124","article-title":"Pharmacokinetics of drugs in avian species and the applications and limitations of dose extrapolation","volume":"85","author":"Houben","year":"2016","journal-title":"Vlaams Diergeneeskd. Tijdschr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1365-2885.1997.00095.x","article-title":"Interspecies allometric meta-analysis of the comparative pharmacokinetics of 44 drugs across veterinary and laboratory animal species","volume":"20","author":"Huang","year":"1997","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1532-0456(02)00184-9","article-title":"Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species","volume":"134","author":"Baert","year":"2003","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"ref_59","unstructured":"Harmegnies, N., Scippo, M.L., and Marchlier, D. (2017). Rapport Final D\u2019Activit\u00e9 \u201cContr\u00f4le de L\u2019Utilisation de Substances Ayant Pour but D\u2019Influencer les Prestations des Pigeons Lors de Comp\u00e9tition\u201d\u2014Projet Subventionn\u00e9 Par la R\u00e9gion Wallonne\u2014DGARNE\u2014Dossier D32-0294, University of Li\u00e8ge."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2307\/1592226","article-title":"Responsiveness of the glucocorticoid-suppressed pituitary-adrenocortical system of pigeons (Columba livia domestica) to stimulation with arginine vasopressin. American Association of Avian Pathologists Stable","volume":"40","author":"Westerhof","year":"1996","journal-title":"Avian Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0016-6480(86)90228-5","article-title":"Flight stimulates adrenocortical activity in pigeons (Columba livia)","volume":"61","author":"Haase","year":"1986","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0016-6480(87)90230-9","article-title":"Adrenocortical responses of pigeons (Columba livia) to treadwheel exercise","volume":"65","author":"Rees","year":"1987","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_63","first-page":"167","article-title":"Pituitary-adrenocortical function and glucocorticoid administration in pigeons (Columba livia domestica)","volume":"12","author":"Westerhof","year":"1998","journal-title":"J. Avian Med. Surg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0076-6879(94)28056-8","article-title":"Biotransformation of hydrocortisone in prednisolone","volume":"228","author":"Kaul","year":"1994","journal-title":"Methods Enzymol."},{"key":"ref_65","first-page":"557","article-title":"Premi\u00e8res observations sur l\u2019utilisation des glucocortico\u00efdes comme agent dopant chez le pigeon voyageur","volume":"137","author":"Duchatel","year":"1993","journal-title":"Ann. Med. Vet."},{"key":"ref_66","first-page":"35","article-title":"Inhibition of molting in pigeons by glucocorticoids","volume":"62","author":"Dhondt","year":"1993","journal-title":"Vlaams Diergeneeskd. Tijdschr."},{"key":"ref_67","first-page":"167","article-title":"Dexamethason und Prednisoloneinsatz bei Tauben [Dexamethasone and prednisolone use in pigeons]","volume":"17","author":"Grimm","year":"1989","journal-title":"Tierarztl. Prax."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF00301171","article-title":"Metabolic responses of homing pigeons to flight and subsequent recovery","volume":"166","author":"Schwilch","year":"1996","journal-title":"J. Comp. Physiol. B"},{"key":"ref_69","first-page":"79","article-title":"Cortisone et cortico\u00efdes, l\u2019euphorie des performances mais la certitudes des d\u00e9faillances et des complications","volume":"4","year":"2002","journal-title":"Courr. Addict."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cvex.2010.09.011","article-title":"Avian analgesia","volume":"14","author":"Hawkins","year":"2011","journal-title":"Vet. Clin. N. Am. Exot. Anim. Pract."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fpls.2020.00338","article-title":"Salicylic acid biosynthesis in plants","volume":"11","author":"Lefevere","year":"2020","journal-title":"Front. Plant Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1039\/c1fo10128e","article-title":"Natural salicylates: Foods, functions and disease prevention","volume":"2","author":"Duthie","year":"2011","journal-title":"Food Funct."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2885.2004.00554.x","article-title":"Comparative metabolic excretion profile of sodium salicylate in broiler chickens and homing pigeons","volume":"27","author":"Baert","year":"2004","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/03079450802056439","article-title":"Toxicological effects of diclofenac in four avian species","volume":"37","author":"Hussain","year":"2008","journal-title":"Avian Pathol."},{"key":"ref_75","first-page":"453","article-title":"Essai d\u2019utilisation du m\u00e9loxicam (Metacam\u00ae Boehringer Ingelheim) chez le pigeon voyageur","volume":"141","author":"Marchlier","year":"1997","journal-title":"Ann. Med. Vet."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2460\/ajvr.73.3.361","article-title":"Lair Analgesic effects of meloxicam administration on postoperative orthopedic ain in domestic pigeons (Columba livia)","volume":"73","author":"DesMarchchelier","year":"2012","journal-title":"Am. J. Vet. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1647\/2010-023.1","article-title":"Clinicopathologic, gross necropsy, and histologic findings after intramuscular injection of carprofen in a pigeon (Columba livia) model","volume":"25","author":"Zollinger","year":"2011","journal-title":"J. Avian Med. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1440-1681.2008.04955.x","article-title":"Anabolic agents for improving muscle regeneration and function after injury","volume":"35","author":"Lynch","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Veuthey, J.-L. (2021). Chapitre 6: La traque aux mol\u00e9cules dopantes. La Chimie et le Sport, EDP Sciences.","DOI":"10.1051\/978-2-7598-0940-0-009"},{"key":"ref_80","unstructured":"Habenicht, U.F., and Aitken, R.J. (2010). Handbook of Experimental Pharmacology, Springer."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Yam, M.F., Loh, Y.C., Tan, C.S., Adam, S.K., Manan, N.A., and Basir, R. (2018). General pathways of pain sensation and the major neurotransmitters involved in pain regulation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082164"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"11934","DOI":"10.1523\/JNEUROSCI.3330-07.2007","article-title":"Opioid-mediated placebo responses boost pain endurance and physical performance: Is it doping in sport competitions?","volume":"27","author":"Benedetti","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1210\/er.2009-0009","article-title":"The effects of opioids and opioid analogs on animal and human endocrine systems","volume":"31","author":"Vuong","year":"2010","journal-title":"Endocr. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1527-3458.2006.00250.x","article-title":"Paracetamol: New vistas of an old drug","volume":"12","author":"Bertolini","year":"2006","journal-title":"CNS Drug Rev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF01965489","article-title":"The avian microcrystal arthritis II. Central versus peripheral effects of sodium salicylate, acetaminophen and colchicine","volume":"4","author":"Brune","year":"1974","journal-title":"Agents Actions"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4103\/0971-6580.72677","article-title":"Study of nephrotoxic potential of acetaminophen in birds","volume":"17","author":"JayakuMarch","year":"2010","journal-title":"Toxicol. Int."},{"key":"ref_87","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1990). Paracetamol. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, International Agency for Research on Caner."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00253-012-4414-4","article-title":"Paracetamol in the environment and its degradation by microorganisms","volume":"96","author":"Wu","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_89","unstructured":"Nott, K., Gillet, M., Carbonnelle, P., Frippiat, C., Moutier, M., Ronkart, S., Delloye, F., and Brahy, V. (2021, December 12). Recherche de Substances Emergentes Dans les Eaux et Int\u00e9ressant la Sant\u00e9 Publique et L\u2019Environnement. Programme de Recherche  IMHOTEP  (Inventaire des Mati\u00e8res Hormonales et Organiques en Traces Dans les Eaux Patrimoniales et Potabilisables). Available online: https:\/\/www.google.com.tw\/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwiUwsq288n1AhXNsVYBHfHoBjAQFnoECAgQAQ&url=http%3A%2F%2Fetat.environnement.wallonie.be%2Ffiles%2FStudies%2F2018_IMHOTEP.pdf&usg=AOvVaw3AsaX6eoQmzZxtCcTmHnen."},{"key":"ref_90","first-page":"341","article-title":"Occurrence of paracetamol in aquatic environments and transformation by microorganisms: A review","volume":"1","author":"Naji","year":"2017","journal-title":"Chronicles Pharm. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.3389\/fgene.2020.549558","article-title":"Varying expression of mu and kappa opioid receptors in cockatiels (Nymphicus hollandicus) and domestic pigeons (Columba livia domestica)","volume":"11","author":"Fousse","year":"2020","journal-title":"Front. Genet."},{"key":"ref_92","unstructured":"Degreef, M., Raats, S., Op de Beek, J., Covacci, A., Eeens, M., van Nuijs, A., and Maudens, K. (2018, January 26\u201330). The pigeon poppy seed defence. Proceedings of the 56th TIAFT Conference, The International Association of Forensic Toxicologists, Ghent, Belgium."},{"key":"ref_93","unstructured":"Raats, S. (2017). De Farmacokinetiek van Opiaten na Toediening van Maanzaad bij Duiven. [Ph.D. Thesis, Karel de Grote Hogeschool, University of Antwerpen]."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1021\/acs.jafc.0c01681","article-title":"Concentrations of the opium alkaloids morphine, codeine, and thebaine in poppy seeds are reduced after thermal and washing treatments but are not affected when Incorporated in a model baked product","volume":"68","author":"Shetge","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3389\/fchem.2020.00737","article-title":"Opium alkaloids in harvested and thermally processed poppy seeds","volume":"8","author":"Carlin","year":"2020","journal-title":"Front. Chem."},{"key":"ref_96","first-page":"e05243","article-title":"Update of the scientific opinion on opium alkaloids in poppy seeds","volume":"16","author":"Knutsen","year":"2018","journal-title":"EFSA J."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1124\/pr.119.018150","article-title":"Pharmacology and therapeutics of bronchodilators revisited","volume":"72","author":"Matera","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4187\/respcare.06051","article-title":"Clinical pharmacology of bronchodilator medications","volume":"63","author":"Williams","year":"2018","journal-title":"Respir. Care"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1136\/vr.l4935","article-title":"Beyond steroids and bronchodilators\u2014Investigating additional therapies for horses with severe equine asthma","volume":"185","author":"Montgomery","year":"2019","journal-title":"Vet. Rec."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.cvex.2011.03.003","article-title":"Avian respiratory distress: Etiology, diagnosis, and treatment","volume":"14","author":"Orosz","year":"2011","journal-title":"Vet. Clin. N. Am. Exot. Anim. Pract."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/dta.2097","article-title":"Control of methylxanthines in the competition horse: Pharmacokinetic\/Pharmacodynamic studies on caffeine, theobromine and theophylline for the assessment of irrelevant concentrations","volume":"9","author":"Machnik","year":"2017","journal-title":"Drug Test. Anal."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neubiorev.2016.09.001","article-title":"A review of caffeine\u2019s effects on cognitive, physical and occupational performance","volume":"71","author":"McLellan","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1042\/bse0440109","article-title":"Caffeine and other sympathomimetic stimulants: Modes of action and effects on sports performance","volume":"44","author":"Cooper","year":"2008","journal-title":"Essays Biochem."},{"key":"ref_104","first-page":"420","article-title":"Ephedra and its application to sport performance: Another concern for the athletic trainer?","volume":"36","author":"Powers","year":"2001","journal-title":"J. Athl. Train."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.euroneuro.2020.07.002","article-title":"How effective are pharmaceuticals for cognitive enhancement in healthy adults? A series of meta-analyses of cognitive performance during administration of modafinil, methylphenidate and D-amphetamine","volume":"38","author":"Roberts","year":"2020","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1136\/bjsm.2008.048348","article-title":"The effects of inhaled L-methamphetamine on athletic performance while riding a stationary bike: A randomised placebo-controlled trial","volume":"43","author":"Dufka","year":"2009","journal-title":"Br. J. Sports Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tips.2014.11.006","article-title":"Amphetamines, new psychoactive drugs and the monoamine transporter cycle","volume":"36","author":"Sitte","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1097\/00005768-200007000-00009","article-title":"Effect of rhEPO administration on serum levels of sTfR and cycling performance","volume":"32","author":"Birkeland","year":"2000","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1055\/s-0030-1255063","article-title":"The hematocrit paradox\u2014How does blood doping really work?","volume":"32","author":"Maassen","year":"2011","journal-title":"Int. J. Sports Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"jeb191056","DOI":"10.1242\/jeb.191056","article-title":"Effects of experimental manipulation of hematocrit on avian flight performance in high- and low-altitude conditions","volume":"221","author":"Yap","year":"2018","journal-title":"J. Exp. Biol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Campbell, T.W. (2015). Exotic Animal Hematology and Cytology, Wiley-Blackwell. [4th ed.].","DOI":"10.1002\/9781118993705"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10336-006-0076-2","article-title":"Effect of endurance flight on haematocrit in migrating birds","volume":"147","author":"Jenni","year":"2006","journal-title":"J. Ornithol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1086\/418649","article-title":"The avian spleen: A neglected organ","volume":"69","author":"John","year":"1994","journal-title":"Q. Rev.Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"6351","DOI":"10.1038\/s41598-019-42921-4","article-title":"Haematological traits co-vary with migratory status, altitude and energy expenditure: A phylogenetic, comparative analysis","volume":"9","author":"Yap","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1053\/j.ctsap.2004.01.006","article-title":"Transfusion medicine in exotic pets","volume":"19","author":"Lichtenberger","year":"2004","journal-title":"Clin. Tech. Small Anim. Pract."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/03079458708436368","article-title":"Action of acth 1\u201324 upon plasma corticosterone concentrations in racing pigeons (Columba livia domestica)","volume":"16","author":"Lumeij","year":"1987","journal-title":"Avian Pathol."},{"key":"ref_117","unstructured":"(2021, December 12). AMCRA Avis de l\u2019AMCRA, Mesures Pour Une Utilisation Responsable des Antibiotiques Chez les Pigeons Voyaguers. Available online: https:\/\/www.amcra.be\/fr\/recent-nieuws\/amcra-a-rdig-un-avis-pour-lapplication-de-mesures-favorisant-un-usage-responsable-des-antibiotiques-chez-les-pigeons-voyageurs\/?lid=15618."},{"key":"ref_118","unstructured":"Marlier, D. (2006, January 11\u201313). Comparaison de l\u2019antibior\u00e9sistance vis-\u00e0-vis de la flum\u00e9quine et de l\u2019enrofloxacine chez des souches d\u2019Escherichia coli d\u2019oiseaux de compagnie ou d\u2019oiseaux de production. Proceedings of the 3\u00e8me Colloque International de Bact\u00e9riologie Francophone, Li\u00e8ge, Belgium."},{"key":"ref_119","first-page":"341","article-title":"Quel antibiotique utiliser pour traiter les affections respiratoires ant\u00e9rieures chez le pigeon","volume":"138","author":"Marlier","year":"1994","journal-title":"Ann. Med. Vet."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/03079450220141679","article-title":"Prevalence of antimicrobial resistance among pigeon isolates of Streptococcus gallolyticus, Escherichia coli and Salmonella enterica serotype Typhimurium","volume":"31","author":"Kimpe","year":"2002","journal-title":"Avian Pathol."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/9\/2\/42\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:06:05Z","timestamp":1760133965000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/9\/2\/42"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,22]]},"references-count":120,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["vetsci9020042"],"URL":"https:\/\/doi.org\/10.3390\/vetsci9020042","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,22]]}}}