{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:58:18Z","timestamp":1760151498635,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>The efficacy of ciclosporin as an adjuvant immunosuppressant administered with glucocorticoids (GCs) for induction of canine PF remission is unknown. This study is a retrospective review of medical records from 2015 to 2020 to evaluate the therapeutic outcomes of 11 PF dogs treated with oral modified ciclosporin and GCs. Concurrent GCs were given with ciclosporin to all PF dogs. Nine dogs (9\/11) achieved complete remission (CR); five dogs received ciclosporin at a mean dose of 6.2 mg\/kg\/day; and four dogs received a combination of ciclosporin and ketoconazole at a mean dose of 3 mg\/kg\/day, respectively. Two dogs (2\/11) showed only 25% or poor response, with the development of new PF lesions during treatment. The mean duration of ciclosporin therapy for nine dogs to achieve CR was 65 days (median 57 days, range 24\u2013119 days). Slow tapering of oral GCs while continuing ciclosporin at the same dose and frequency in nine dogs with CR led to recurrence of PF lesions in four dogs, whereas, in five dogs, oral glucocorticoids were discontinued without a PF flare. Oral modified ciclosporin combined with GCs achieved CR in 9 out of 11 PF dogs during the induction phase in this study.<\/jats:p>","DOI":"10.3390\/vetsci9040153","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T22:08:06Z","timestamp":1648073286000},"page":"153","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Retrospective Evaluation of the Steroid-Sparing Effect of Oral Modified Ciclosporin for Treatment of Canine Pemphigus Foliaceus"],"prefix":"10.3390","volume":"9","author":[{"given":"Eric","family":"Chong","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Austel","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4785-4121","authenticated-orcid":false,"given":"Frane","family":"Banovic","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"ref_1","first-page":"410-e110","article-title":"Open trial of Bruton\u2019s tyrosine kinase inhibitor (PRN1008) in the treatment of canine pemphigus foliaceus","volume":"31","author":"Goodale","year":"2020","journal-title":"Vet. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/vde.12241","article-title":"Oral glucocorticoid pulse therapy for induction of treatment of canine pemphigus foliaceus\u2014A comparative study","volume":"26","author":"Bizikova","year":"2015","journal-title":"Vet. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cvsm.2010.02.003","article-title":"Autoimmune diseases in small animals","volume":"40","author":"Gershwin","year":"2010","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"77-e24","DOI":"10.1111\/vde.13028","article-title":"A retrospective evaluation of the steroid sparing effects of oral mycophenolate mofetil (MMF) as an adjunct immunosuppressant for the treatment of canine pemphigus foliaceus","volume":"33","author":"Putra","year":"2022","journal-title":"Vet. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jvim.12265","article-title":"Oral cyclosporine treatment in dogs: A review of the literature","volume":"28","author":"Archer","year":"2014","journal-title":"J. Vet. Intern. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1136\/vr.152.2.53","article-title":"Efficacy of cyclosporine for treatment induction of canine pemphigus foliaceus","volume":"152","author":"Olivry","year":"2003","journal-title":"Vet. Rec."},{"key":"ref_7","first-page":"340","article-title":"Therapeutic effect of cyclosporine administration in a dog with pemphigus foliaceus","volume":"26","author":"Kim","year":"2009","journal-title":"J. Vet. Clin."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-3164.2006.00540.x","article-title":"A review of autoimmune skin diseases in domestic animals: I-superficial pemphigus","volume":"17","author":"Olivry","year":"2006","journal-title":"Vet. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/bjd.15930","article-title":"British Association of Dermatologists\u2019 guidelines for the management of pemphigus vulgaris 2017","volume":"177","author":"Harman","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"195-e44","DOI":"10.1111\/vde.12400","article-title":"Use of mycophenolate mofetil to treat immune-mediated skin disease in 14 dogs\u2014A retrospective evaluation","volume":"28","author":"Ackermann","year":"2017","journal-title":"Vet. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"598-e144","DOI":"10.1111\/vde.12081","article-title":"Use of prednisolone as monotherapy in the treatment of feline pemphigus foliaceus: A retrospective study of 37 cats","volume":"24","author":"Simpson","year":"2013","journal-title":"Vet. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"403-e76","DOI":"10.1111\/j.1365-3164.2012.01069.x","article-title":"Use of modified ciclosporin in the management of feline pemphigus foliaceus: A retrospective analysis","volume":"23","author":"Irwin","year":"2012","journal-title":"Vet. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1365-3164.2012.01064.x","article-title":"The effect of ketoconazole on whole blood and skin ciclosporin concentrations in dogs","volume":"24","author":"Gray","year":"2013","journal-title":"Vet. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cvsm.2012.09.007","article-title":"Cyclosporine in veterinary dermatology","volume":"43","author":"Palmeiro","year":"2013","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_15","unstructured":"Papich, M. (2016). Saunders Handbook of Veterinary Drugs Small and Large Animal, Elsevier. [4th ed.]."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.3389\/fmed.2021.723982","article-title":"Gene Expression Analysis in Four Dogs with Canine Pemphigus Clinical Subtypes Reveals B Cell Signatures and Immune Activation Pathways Similar to Human Disease","volume":"8","author":"Raef","year":"2021","journal-title":"Front. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.coi.2019.09.004","article-title":"B cell targeted therapies in autoimmune disease","volume":"61","author":"Barnas","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cvsm.2018.08.006","article-title":"Canine Perianal Fistulas: Clinical Presentation, Pathogenesis, and Management","volume":"49","author":"Cain","year":"2019","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Olivry, T., Linder, K.E., and Banovic, F. (2018). Cutaneous lupus erythematosus in dogs: A comprehensive review. BMC Vet. Res., 14.","DOI":"10.1186\/s12917-018-1446-8"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.2460\/javma.256.11.1245","article-title":"Clinical, clinicopathologic, and hepatic histopathologic features associated with probable ketoconazole-induced liver injury in dogs: 15 cases (2015\u20132018)","volume":"256","author":"Macho","year":"2020","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1111\/jvim.14831","article-title":"Thrombocytosis in 715 Dogs (2011\u20132015)","volume":"31","author":"Woolcock","year":"2017","journal-title":"J. Vet. Intern. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1751-0813.2009.00474.x","article-title":"Transient hyperglycaemia in a prediabetic dog treated with prednisone and cyclosporin A","volume":"87","author":"Murray","year":"2009","journal-title":"Aust. Vet. J."},{"key":"ref_23","first-page":"291-e71","article-title":"Efficacy of a Bruton\u2019s Tyrosine Kinase Inhibitor (PRN-473) in the treatment of canine pemphigus foliaceus","volume":"31","author":"Goodale","year":"2020","journal-title":"Vet. 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