{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:19:21Z","timestamp":1760228361302,"version":"build-2065373602"},"reference-count":18,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Tumors of sweat glands usually originate from apocrine glands and can develop throughout the body but are rare in dogs. This report describes the retroperitoneal metastasis of primary cutaneous apocrine adenocarcinoma. An 8-year-old, spayed female beagle dog, weighing 11.7 kg, presented with a history of anorexia, hypodynamia, and weight loss. Clinical examination, radiography, ultrasonography, and computed tomography revealed a skin mass on the dorsum of the right metatarsal region, an enlarged ipsilateral popliteal lymph node, and a retroperitoneal mass. Fine-needle aspiration cytology of the popliteal lymph node suggested metastasis of an apocrine sweat gland tumor. Surgical excision of the skin mass, popliteal lymph node, and retroperitoneal mass was performed. The retroperitoneal mass was diagnosed as a metastasis of primary cutaneous apocrine adenocarcinoma. Immunohistochemistry revealed that the tumor cells were positive for cytokeratin 7 but negative for cytokeratin 20 and S100 proteins. There were no postoperative complications, except for temporary hindlimb edema, including local recurrence or metastasis, in the 6-month postoperative follow-up period. This case illustrates that although malignant apocrine gland tumors are rare in dogs, a wide resection of primary cutaneous apocrine gland adenocarcinomas is recommended because of the risk of local invasion or distant metastasis.<\/jats:p>","DOI":"10.3390\/vetsci9050234","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T23:08:36Z","timestamp":1652396916000},"page":"234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retroperitoneal Metastatic Apocrine Gland Ductal Adenocarcinoma in a Beagle Dog"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3530-9860","authenticated-orcid":false,"given":"Chang-Hwan","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, 99 Daehak-ro, Yuseong-gu, DaeJeon 34134, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Ah","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, 99 Daehak-ro, Yuseong-gu, DaeJeon 34134, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae-Beom","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, 99 Daehak-ro, Yuseong-gu, DaeJeon 34134, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8653-5927","authenticated-orcid":false,"given":"Seong-Mok","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, 99 Daehak-ro, Yuseong-gu, DaeJeon 34134, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3525-3812","authenticated-orcid":false,"given":"Dae-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, 99 Daehak-ro, Yuseong-gu, DaeJeon 34134, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"ref_1","unstructured":"Withrow, S., Vail, D., and Page, R. (2012). Withrow and MacEwen\u2019s Small Animal Clinical Oncology, Elsevier."},{"key":"ref_2","unstructured":"Gross, T.L., Ihrke, P.J., Walder, E.J., and Affolter, V.K. (2008). Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis, John Wiley & Sons."},{"key":"ref_3","first-page":"151","article-title":"Schweissdr\u00fcsenkarzinome der Haut [Sweat gland carcinomas of the skin]","volume":"59","author":"Requena","year":"2008","journal-title":"Hautarzt"},{"key":"ref_4","unstructured":"Valli, V., Bienzle, D., Meuten, D., and Linder, K. (2017). Tumors in Domestic Animals, John Wiley & Sons."},{"key":"ref_5","first-page":"38","article-title":"A retrospective study of 44 canine apocrine sweat gland adenocarcinomas","volume":"44","author":"Simko","year":"2003","journal-title":"Can. Vet. J."},{"key":"ref_6","first-page":"400","article-title":"Neoplasms of the apocrine sweat glands in 44 dogs and 10 cats","volume":"127","author":"Kalaher","year":"1990","journal-title":"Vet. 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Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1751-0813.2005.tb15626.x","article-title":"Anal sac tumours of the dog and their response to cytoreductive surgery and chemotherapy","volume":"83","author":"Emms","year":"2005","journal-title":"Austr. Vet. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1939-1676.2007.tb02960.x","article-title":"Clinical stage, therapy, and prognosis in canine anal sac gland carcinoma","volume":"21","author":"Polton","year":"2007","journal-title":"J. Vet. Int. 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