{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:55:06Z","timestamp":1792806906067,"version":"4.5.0"},"reference-count":92,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["32060783"],"award-info":[{"award-number":["32060783"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the National Natural Science Foundation of China","award":["32060752"],"award-info":[{"award-number":["32060752"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the National Natural Science Foundation of China","award":["2021LQGR53"],"award-info":[{"award-number":["2021LQGR53"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the National Natural Science Foundation of China","award":["2021QB-034"],"award-info":[{"award-number":["2021QB-034"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Longyuan Youth Innovation and Entrepreneurship Talent Project","award":["32060783"],"award-info":[{"award-number":["32060783"]}]},{"name":"the Longyuan Youth Innovation and Entrepreneurship Talent Project","award":["32060752"],"award-info":[{"award-number":["32060752"]}]},{"name":"the Longyuan Youth Innovation and Entrepreneurship Talent Project","award":["2021LQGR53"],"award-info":[{"award-number":["2021LQGR53"]}]},{"name":"the Longyuan Youth Innovation and Entrepreneurship Talent Project","award":["2021QB-034"],"award-info":[{"award-number":["2021QB-034"]}]},{"name":"the Young Doctor Fund Project of Gansu Provincial Department of Education","award":["32060783"],"award-info":[{"award-number":["32060783"]}]},{"name":"the Young Doctor Fund Project of Gansu Provincial Department of Education","award":["32060752"],"award-info":[{"award-number":["32060752"]}]},{"name":"the Young Doctor Fund Project of Gansu Provincial Department of Education","award":["2021LQGR53"],"award-info":[{"award-number":["2021LQGR53"]}]},{"name":"the Young Doctor Fund Project of Gansu Provincial Department of Education","award":["2021QB-034"],"award-info":[{"award-number":["2021QB-034"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Melatonin, a hormone produced by the mammalian pineal gland, influences various physiological activities, many of which are related to animal reproduction, including neuroendocrine function, rhythm regulation, seasonal behavior, gonadogenesis, gamete development and maturation, sexual maturation, and thermoregulation. Melatonin exerts beneficial actions mainly via binding with G-protein-coupled receptors (GPCR), termed MT1 and MT2. Melatonin receptors are crucial for mediating animal reproduction. This paper reviews the characteristics of melatonin receptors including MT1 and MT2, as well as their roles in mediating signal transduction and biological effects, with a focus on their function in animal reproduction. In addition, we briefly summarize the developments in pharmacological research regarding melatonin receptors as drug targets. It is expected that this review will provide a reference for further exploration and unveiling of melatonin receptor function in reproductive regulation.<\/jats:p>","DOI":"10.3390\/vetsci9070309","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T01:59:47Z","timestamp":1655949587000},"page":"309","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Melatonin Receptors: A Key Mediator in Animal Reproduction"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6149-5487","authenticated-orcid":false,"given":"Yuan","family":"Gao","sequence":"first","affiliation":[{"name":"College of Life Science and Technology, Gansu Agricultural University, Lanzhou 730070, China"},{"name":"Gansu Key Laboratory of Animal Generational Physiology and Reproductive Regulation, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Gansu Key Laboratory of Animal Generational Physiology and Reproductive Regulation, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gansu Key Laboratory of Animal Generational Physiology and Reproductive Regulation, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5476-508X","authenticated-orcid":false,"given":"Quanwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Gansu Agricultural University, Lanzhou 730070, China"},{"name":"Gansu Key Laboratory of Animal Generational Physiology and Reproductive Regulation, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/0960327113489052","article-title":"Melatonin ameliorates oxidative stress and reproductive toxicity induced by cyclophosphamide in male mice","volume":"33","author":"Chabra","year":"2014","journal-title":"Hum. 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