{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:15:46Z","timestamp":1787030146477,"version":"build-2736575974"},"reference-count":10,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>A 6-year-old mixed-breed male Papillon dog, castrated at the age of 7 months, presented for work-up of a difficulty walking associated with constipation and urinary incontinence. Ultrasonography and radiography were consistent with a tumor of the prostate and lymph node metastases. An irregular osteoproliferation of the ventral edges of L5\u2013L6\u2013L7 suggested tumor invasion. Periosteal proliferative lesions of the pelvis, the femur, the humerus, the tibia and the calcaneus were consistent with hypertrophic osteopathy. Necropsy and histological examination confirmed the diagnosis of prostatic adenocarcinoma with lymph node, pulmonary, liver and bone metastases, associated with hypertrophic osteopathy.<\/jats:p>","DOI":"10.3390\/vetsci9090466","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T02:09:36Z","timestamp":1661911776000},"page":"466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypertrophic Osteopathy Associated with a Prostatic Adenocarcinoma in a Castrated Dog"],"prefix":"10.3390","volume":"9","author":[{"given":"Fran\u00e7oise A.","family":"Roux","sequence":"first","affiliation":[{"name":"Emergency and Critical Care Unit, Oniris, Nantes-Atlantic College of Veterinary Medicine, Food Science and Engineering, La Chantrerie, CS 40706, CEDEX 03, 44307 Nantes, France"},{"name":"Nutrition, PathoPhysiology and Pharmacology (NP3) Unit, Oniris, Nantes-Atlantic College of Veterinary Medicine, Food Science and Engineering, La Chantrerie, CS 40706, CEDEX 03, 44307 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Deseille","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Unit, Oniris, Nantes-Atlantic College of Veterinary Medicine, Food Science and Engineering, La Chantrerie, CS 40706, CEDEX 03, 44307 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5336-9352","authenticated-orcid":false,"given":"Marion","family":"Fusellier","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, CRIP, Oniris, Nantes-Atlantic College of Veterinary Medicine, Food Science and Engineering, La Chantrerie, CS 40706, CEDEX 03, 44307 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Rohel","sequence":"additional","affiliation":[{"name":"Department of Biology, Pathology and Food Sciences, Laboniris, Oniris, Nantes-Atlantic College of Veterinary Medicine, Food Science and Engineering, La Chantrerie, CS 40706, CEDEX 03, 44307 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8460-9352","authenticated-orcid":false,"given":"Julien","family":"Branchereau","sequence":"additional","affiliation":[{"name":"Institut de Transplantation-Urologie-N\u00e9phrologie, CHU de Nantes, 30 Boulebard Jean Monnet, CEDEX 1, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3363-7457","authenticated-orcid":false,"given":"Jack-Yves","family":"Deschamps","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Unit, Oniris, Nantes-Atlantic College of Veterinary Medicine, Food Science and Engineering, La Chantrerie, CS 40706, CEDEX 03, 44307 Nantes, France"},{"name":"Nutrition, PathoPhysiology and Pharmacology (NP3) Unit, Oniris, Nantes-Atlantic College of Veterinary Medicine, Food Science and Engineering, La Chantrerie, CS 40706, CEDEX 03, 44307 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0303-7207(02)00261-7","article-title":"Canine prostate carcinoma: Epidemiological evidence of an increased risk in castrated dogs","volume":"197","author":"Teske","year":"2002","journal-title":"Mol. 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