{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:36:44Z","timestamp":1773679004644,"version":"3.50.1"},"reference-count":8,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Glucocorticoids are widely used to treat canine allergic disorders, but they frequently cause polyuria and polydipsia (PUPD). At equipotent dosages, oral methylprednisolone is believed to cause less PUPD than prednisolone. We performed a pilot randomized, open, parallel trial with 22 dogs with nonseasonal AD receiving either prednisolone or methylprednisolone at equipotent dosages, once daily for 14 days during the first phase of a restriction\u2013provocation dietary trial. Before and on days 3, 7, and 14 after starting the glucocorticoids, owners estimated water consumption for 24 h. On the same days and before the glucocorticoid was given, owners collected the first-morning urine to determine the urine specific gravity (USG). There were no significant differences between the prednisolone and methylprednisolone groups on days 3, 7, and 14 when comparing the changes in water intake from baseline. Most dogs from both groups exhibited a slight reduction in USG during the study. Still, there was no significant difference in USG changes between the groups on any of these three reevaluation days. In conclusion, the administration of two weeks of oral prednisolone and methylprednisolone at equipotent anti-inflammatory dosages at the beginning of an elimination diet did not lead to significant differences in water intake and USG.<\/jats:p>","DOI":"10.3390\/vetsci9090490","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:15:02Z","timestamp":1663114502000},"page":"490","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Pilot Randomized Trial to Compare Polyuria and Polydipsia during a Short Course of Prednisolone or Methylprednisolone in Dogs with Atopic Dermatitis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5974-1204","authenticated-orcid":false,"given":"Viktorija","family":"Lokianskiene","sequence":"first","affiliation":[{"name":"VetPet LT, Sodu g. 19, 55167 Jonava, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9531-4613","authenticated-orcid":false,"given":"Kerstin","family":"Bergvall","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine and Animal Husbandry, Swedish University of Agricultural Sciences, P.O. Box 7054, 75007 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1399-0034","authenticated-orcid":false,"given":"Thierry","family":"Olivry","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, NC State University, 1060 William Moore Drive, Raleigh, NC 27607, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fvets.2020.00515","article-title":"Side effects to systemic glucocorticoid therapy in dogs under primary veterinary care in the UK","volume":"7","author":"Elkholly","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"ref_2","unstructured":"Miller, W.H., Griffin, C.E., and Campbell, K. (2012). 3. Dermatologic therapy. Muller & Kirk\u2019s Small Animal Dermatology, Saunders."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1710-1492-9-30","article-title":"A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Olivry, T., DeBoer, D.J., Favrot, C., Jackson, H.A., Mueller, R.S., Nuttall, T., and Pr\u00e9laud, P. (2015). Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). BMC Vet. Res., 11.","DOI":"10.1186\/s12917-015-0514-6"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"498-e149","DOI":"10.1111\/vde.12793","article-title":"The usefulness of short-course prednisolone during the initial phase of an elimination diet trial in dogs with food-induced atopic dermatitis","volume":"30","author":"Favrot","year":"2019","journal-title":"Vet. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/vcp.12781","article-title":"Variability among four refractometers for the measurement of urine specific gravity and comparison with urine osmolality in dogs","volume":"48","author":"Rudinsky","year":"2019","journal-title":"Vet. Clin. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/01.NURSE.0000325315.41513.a0","article-title":"What is urine specific gravity","volume":"38","author":"Flasar","year":"2008","journal-title":"Nursing"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1046\/j.1439-0442.2003.00542.x","article-title":"Comparison of the techniques of evaluation of urine dilution\/concentration in the dog","volume":"50","author":"Dossin","year":"2003","journal-title":"J. Vet. Med. Physiol. Pathol. Clin. Med."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/9\/9\/490\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:28:14Z","timestamp":1760142494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/9\/9\/490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,9]]},"references-count":8,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["vetsci9090490"],"URL":"https:\/\/doi.org\/10.3390\/vetsci9090490","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,9]]}}}