{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:16:04Z","timestamp":1787030164411,"version":"build-2736575974"},"reference-count":20,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Iowa Livestock Health Advisory Council","award":["FY20"],"award-info":[{"award-number":["FY20"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Coronaviruses use a broad range of host receptors for binding and cell entry, essential steps in establishing viral infections. This pilot study evaluated the overall distribution of angiotensin-converting enzyme 2 (ACE2), aminopeptidase N (APN), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and dipeptidyl peptidase 4 (DPP4) receptors in the pig respiratory and intestinal tract. All the receptors evaluated in this study were expressed and differentially distributed through the respiratory and intestinal tract. The presence and expression levels of these receptors could determine susceptibility to coronavirus infections. This study may have important implications for the development of research models and the assessment of the potential risk and introduction of novel coronaviruses into the swine population.<\/jats:p>","DOI":"10.3390\/vetsci9090500","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:15:02Z","timestamp":1663114502000},"page":"500","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Distribution of Coronavirus Receptors in the Swine Respiratory and Intestinal Tract"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-0943","authenticated-orcid":false,"given":"Rahul","family":"Nelli","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Iowa State University, Ames, IA 50010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Roth","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Iowa State University, Ames, IA 50010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4407-7996","authenticated-orcid":false,"given":"Luis","family":"Gimenez-Lirola","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Iowa State University, Ames, IA 50010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Coronaviruses: An Overview of Their Replication and Pathogenesis","volume":"Volume 226","author":"Fehr","year":"2015","journal-title":"Coronaviruses: Methods and Protocols"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3181\/0903-MR-94","article-title":"Coronavirus Diversity, Phylogeny and Interspecies Jumping","volume":"234","author":"Woo","year":"2009","journal-title":"Exp. 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