{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:58:06Z","timestamp":1790330286424,"version":"4.1.0"},"reference-count":28,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"the Japan Society for the Promotion of Science (JSPS) KAK-ENHI","doi-asserted-by":"publisher","award":["20K15667"],"award-info":[{"award-number":["20K15667"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"the Japan Society for the Promotion of Science (JSPS) KAK-ENHI","doi-asserted-by":"publisher","award":["22K05995"],"award-info":[{"award-number":["22K05995"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>An 11-year-old intact female Papillion weighing 2.1 kg was referred to our institution with the main complaint of shallow, rapid breathing. At the first visit (day 0), although clinical signs improved due to the use of medication from the primary hospital, transthoracic radiography and echocardiography revealed left heart enlargement and left ventricular dysfunction. A clinical diagnosis of dilated cardiomyopathy (DCM) was made and oral administration of pimobendan, temocapril, and taurine was initiated. However, on day 10, the respiratory status worsened and furosemide was prescribed. On day 54, no significant improvement in heart size was observed. Additionally, the diet that this patient received met the recommendation for diet-related DCM by the U.S. Food and Drug Administration, and the patient\u2019s diet was changed from a grain-free diet to a grain-containing diet. On day 1191, the patient\u2019s respiratory status was stable and no clinical signs were observed. Transthoracic radiography and echocardiography revealed an improvement in left heart size. Additionally, improvements in the left and right ventricular myocardial strains were observed after changing the diet. We suggest that it may be necessary to suspect a dietary association with dilated cardiomyopathy, and a good prognosis might be expected by dietary modification, even in small-breed dogs.<\/jats:p>","DOI":"10.3390\/vetsci9110593","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T22:36:17Z","timestamp":1666910177000},"page":"593","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Case of a Small-Breed Dog with Diet-Related Dilated Cardiomyopathy Showing Marked Improvements in Cardiac Morphology and Function after Dietary Modification"],"prefix":"10.3390","volume":"9","author":[{"given":"Takahiro","family":"Saito","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, School of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9451-5854","authenticated-orcid":false,"given":"Ryohei","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, School of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-7320","authenticated-orcid":false,"given":"Yunosuke","family":"Yuchi","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, School of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3028-779X","authenticated-orcid":false,"given":"Yuyo","family":"Yasumura","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, School of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9646-6785","authenticated-orcid":false,"given":"Takahiro","family":"Teshima","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, School of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, School of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Koyama","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, School of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1760-2734(06)70047-9","article-title":"Proposed Guidelines for the Diagnosis of Canine Idiopathic Dilated Cardiomyopathy","volume":"5","author":"Borgarelli","year":"2003","journal-title":"J. Vet. Cardiol."},{"key":"ref_2","first-page":"370","article-title":"Relationship between Circulating and Dietary Taurine Concentrations in Dogs with Dilated Cardiomyopathy","volume":"2","author":"Freeman","year":"2001","journal-title":"Vet. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.2460\/javma.2003.223.1130","article-title":"Taurine Deficiency in Newfoundlands Fed Commercially Available Complete and Balanced Diets","volume":"223","author":"Backus","year":"2003","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"742","DOI":"10.5455\/vetworld.2012.742-747","article-title":"Hypothyroidism\u2014A Cause for Dilated Cardiomyopathy in Dogs; Four Year Study 2008\u20132011","volume":"5","author":"Karlapudi","year":"2012","journal-title":"Vet. World"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13620-014-0028-8","article-title":"Myocarditis in Dogs: Etiology, Clinical and Histopathological Features (11 Cases: 2007\u20132013)","volume":"67","author":"Janus","year":"2014","journal-title":"Ir. Vet. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2460\/javma.1997.210.04.505","article-title":"Clinical and Pathologic Findings in Doberman Pinschers with Occult Cardiomyopathy That Died Suddenly or Developed Congestive Heart Failure: 54 Cases (1984\u20131991)","volume":"210","author":"Calvert","year":"1997","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/jvim.15972","article-title":"Retrospective Study of Dilated Cardiomyopathy in Dogs","volume":"35","author":"Freid","year":"2021","journal-title":"J. Vet. Intern Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jvc.2021.02.001","article-title":"Association of Diet with Clinical Outcomes in Dogs with Dilated Cardiomyopathy and Congestive Heart Failure","volume":"40","author":"Walker","year":"2022","journal-title":"J. Vet. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/jvim.12024","article-title":"Noninvasive Clinical Assessment of Systolic Torsional Motions by Two-Dimensional Speckle-Tracking Echocardiography in Dogs with Myxomatous Mitral Valve Disease","volume":"27","author":"Suzuki","year":"2013","journal-title":"J. Vet. Intern Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/jvim.12293","article-title":"Dobutamine Stress Echocardiography for Assessment of Systolic Function in Dogs with Experimentally Induced Mitral Regurgitation","volume":"28","author":"Suzuki","year":"2014","journal-title":"J. Vet. Intern Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jvc.2012.12.004","article-title":"Influence of Heart Rate on Myocardial Function Using Two-Dimensional Speckle-Tracking Echocardiography in Healthy Dogs","volume":"15","author":"Suzuki","year":"2013","journal-title":"J. Vet. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jvc.2013.07.001","article-title":"Effect of Age on Myocardial Function Assessed by Two-Dimensional Speckle-Tracking Echocardiography in Healthy Beagle Dogs","volume":"15","author":"Suzuki","year":"2013","journal-title":"J. Vet. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Suzuki, R., Yuchi, Y., Kanno, H., Teshima, T., Matsumoto, H., and Koyama, H. (2021). Left and Right Myocardial Functionality Assessed by Two-Dimensional Speckle-Tracking Echocardiography in Cats with Restrictive Cardiomyopathy. Animals, 11.","DOI":"10.3390\/ani11061578"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jvc.2012.09.001","article-title":"Clinical Assessment of Systolic Myocardial Deformations in Dogs with Chronic Mitral Valve Insufficiency Using Two-Dimensional Speckle-Tracking Echocardiography","volume":"15","author":"Suzuki","year":"2013","journal-title":"J. Vet. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1292\/jvms.21-0195","article-title":"Right Ventricular Systolic and Diastolic Function Assessed by Two-Dimensional Speckle Tracking Echocardiography in Dogs with Myxomatous Mitral Valve Disease","volume":"83","author":"Yuchi","year":"2021","journal-title":"J. Vet. Med. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1751-0147-55-41","article-title":"Speckle Tracking Echocardiography in Mature Irish Wolfhound Dogs: Technical Feasibility, Measurement Error and Reference Intervals","volume":"55","author":"Westrup","year":"2013","journal-title":"Acta Vet. Scand."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4142\/jvs.2013.14.3.355","article-title":"Evaluation of Changes in Left Ventricular Myocardial Function Observed in Canine Myocardial Dysfunction Model Using a Two-Dimensional Tissue Tracking Technique","volume":"14","author":"Hamabe","year":"2013","journal-title":"J. Vet. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1476-7120-11-43","article-title":"Left Ventricular Strain Distribution in Healthy Dogs and in Dogs with Tachycardia-Induced Dilated Cardiomyopathy","volume":"11","author":"Kusunose","year":"2013","journal-title":"Cardiovasc. Ultrasound"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jvc.2017.06.002","article-title":"Assessment of Left Ventricular Function in Healthy Great Danes and in Great Danes with Dilated Cardiomyopathy Using Speckle Tracking Echocardiography","volume":"19","author":"Pedro","year":"2017","journal-title":"J. Vet. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jvc.2010.08.001","article-title":"Comparison of Longitudinal Myocardial Tissue Velocity, Strain, and Strain Rate Measured by Two-Dimensional Speckle Tracking and by Color Tissue Doppler Imaging in Healthy Dogs","volume":"13","author":"Wess","year":"2011","journal-title":"J. Vet. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jvc.2011.11.002","article-title":"Left Ventricular Function Quantified by Myocardial Strain Imaging in Small-Breed Dogs with Chronic Mitral Regurgitation","volume":"14","author":"Smith","year":"2012","journal-title":"J. Vet. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Hamabe, L., Mandour, A.S., Shimada, K., Uemura, A., Yilmaz, Z., Nagaoka, K., and Tanaka, R. (2021). Role of Two-Dimensional Speckle-Tracking Echocardiography in Early Detection of Left Ventricular Dysfunction in Dogs. Animals, 11.","DOI":"10.3390\/ani11082361"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"15881","DOI":"10.1038\/s41598-021-94464-2","article-title":"Investigation of Diets Associated with Dilated Cardiomyopathy in Dogs Using Foodomics Analysis","volume":"11","author":"Smith","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1939-1676.2007.0037.x","article-title":"Noninvasive Assessment of Systolic Left Ventricular Torsion by 2-Dimensional Speckle Tracking Imaging in the Awake Dog: Repeatability, Reproducibility, and Comparison with Tissue Doppler Imaging Variables","volume":"22","author":"Chetboul","year":"2008","journal-title":"J. Vet. Intern Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1177\/1098612X17691896","article-title":"Determination of Multidirectional Myocardial Deformations in Cats with Hypertrophic Cardiomyopathy by Using Two-Dimensional Speckle-Tracking Echocardiography","volume":"19","author":"Suzuki","year":"2017","journal-title":"J. Feline Med. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1111\/jvim.15495","article-title":"Speckle Tracking Echocardiography in Cats with Preclinical Hypertrophic Cardiomyopathy","volume":"33","author":"Spalla","year":"2019","journal-title":"J. Vet. Intern. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Saito, T., Suzuki, R., Yuchi, Y., Teshima, T., Matsumoto, H., and Koyama, H. (2021). Early Detection of Myocardial Dysfunction in a Cat That Gradually Progressed to Endomyocardial Form of Restrictive Cardiomyopathy. BMC Vet. Res., 17.","DOI":"10.1186\/s12917-021-02987-7"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00439-012-1158-2","article-title":"A Splice Site Mutation in a Gene Encoding for PDK4, a Mitochondrial Protein, Is Associated with the Development of Dilated Cardiomyopathy in the Doberman Pinscher","volume":"131","author":"Meurs","year":"2012","journal-title":"Hum. Genet."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/9\/11\/593\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:03:55Z","timestamp":1760144635000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/9\/11\/593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":28,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["vetsci9110593"],"URL":"https:\/\/doi.org\/10.3390\/vetsci9110593","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,27]]}}}