{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:32:21Z","timestamp":1760232741410,"version":"build-2065373602"},"reference-count":45,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Several studies performed in humans have demonstrated that the onset of systemic inflammatory response syndrome (SIRS) represents a high risk condition to develop myocardial damage and arrhythmias. Therefore, we also hypothesized cardiac involment for dogs affected by SIRS. To assess this hypothesis, 24 dogs with a diagnosis of SIRS (13 entire males, 7 entire females, and 4 spayed females) with an age ranging from 4 to 11 years (mean 5.6 years) and an average weight of 24 kg (range from 5 to 47 kg) were enrolled. The dogs were divided into two groups according to their prognosis: Survivors (G1) and not survivors (G2), composed by 13 and 11 dogs, respectively. Moreover, healthy dogs were included as the control group (CTR). All the dogs with a history of cardiac or renal disease were excluded. At the inclusion, each patient underwent a physical examination and a complete cell count, and a biochemistry panel (including electrolyte profile) was performed; moreover, the blood cardiac Troponin I (cTnI) was measured. For each clinical variable indicative of SIRS, a score between 0 (absence) and 1 (presence) was applied. Furthermore, an electrocardiographic examination was recorded. Seventeen out of 24 (70.8%) dogs with SIRS showed arrhythmias, of which n. 6 belonged to the G1, while n. 11 belonged to the G2. Most represented findings were sinus tachycardia (7\/17; 41.1%), followed by monomorphic premature ventricular beats (6\/17; 35.3%), less common were first-degree atrioventricular block (2\/17; 11.7%) and sinus bradycardia 1\/17; 5.8%). Notably, in G1 dogs, only sinus tachycardia and premature ventricular beats were observed. G2 dogs presented a number of total and banded leukocytes significantly higher than those of G1 (p = 0.002 and 0.049), in the same manner, the clinical score suggestive of SIRS (3 vs. 2.1) was significantly higher in G2 than in G1 dogs (p = 0.01). Moreover, a significantly higher value of cTnI was observed in the G2 group compared to the G1 group (p = 0.006). Data presented here suggested a cardiac involvement in dogs with SIRS, analogously to humans, that may significantly influence the patient\u2019s prognosis.<\/jats:p>","DOI":"10.3390\/vetsci9120655","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T02:54:05Z","timestamp":1669258445000},"page":"655","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Electrocardiographic Findings and Cardiac Troponin I Assay in Dogs with SIRS Diagnosis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0440-5457","authenticated-orcid":false,"given":"Michela","family":"Pugliese","sequence":"first","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Via Umberto Palatucci, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocky","family":"La Maestra","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Via Umberto Palatucci, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7686-7717","authenticated-orcid":false,"given":"Monica","family":"Ragusa","sequence":"additional","affiliation":[{"name":"Complex Structure of Surgical Sciences and Technologies, IRCCS\u2014Scientific Institute for Research, Hospitalization and Healthcare\u2014Istituto Ortopedico Rizzoli, Via Di Barbiano 1\/10, 40136 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8764-1956","authenticated-orcid":false,"given":"Mehmet Erman","family":"Or","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, \u0130stanbul University-Cerrahpasa, Istanbul 34098, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giordana","family":"Merola","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Via Umberto Palatucci, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ettore","family":"Napoli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Via Umberto Palatucci, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1701-3636","authenticated-orcid":false,"given":"Annamaria","family":"Passantino","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Via Umberto Palatucci, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"ref_1","unstructured":"Silverstein, D.C., and Hopper, K. 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