{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:38:06Z","timestamp":1760233086378,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["#313911\/2021-5"],"award-info":[{"award-number":["#313911\/2021-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>This paper aims to report clinical, laboratory, radiographic, and pathological features in a case of cervical vertebral stenotic myelopathy (CVSM) affecting a 4-month-old Nelore calf for the first time. During physical examination, the calf could stand if assisted when lifting by the tail but fallen to the ground when trying to walk. Attempts to flex and extend the neck to the right side failed. Radiographs findings consisted of reduced intervertebral spaces, and misalignments between the endplates, more evident between the C3 and C4 vertebrae, resulting in narrowing of the spinal canal and compression of the spinal cord. Grossly, C4 showed cranial articular surface malformation, abnormal metaphyseal growth plate development, reduced vertebral body size and deformity. Histologically, C4 showed an abnormal vertebral bone development characterized by moderate replacement of trabecular bone by fibrous tissues, multifocal areas of dystrophic hyaline cartilage development, and cartilaginous growth failure along the metaphyseal growth plate. Cervical spinal cord within the stenotic vertebral canal showed swollen neurons with central chromatolysis, areas of Wallerian degeneration, and necrotic debris. In contrast with the well-known Wobbler syndrome in horses, the etiology of CVSM in cattle remains undetermined, and further genetic and pathological studies must be conducted to elucidate it.<\/jats:p>","DOI":"10.3390\/vetsci9120699","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T04:30:00Z","timestamp":1671165000000},"page":"699","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cervical Vertebral Stenotic Myelopathy in a Nelore Calf"],"prefix":"10.3390","volume":"9","author":[{"given":"Mariana de Oliveira","family":"Bonow","sequence":"first","affiliation":[{"name":"Large Animal Veterinary Teaching Hospital, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Galp\u00e3o 4, Granja do Torto, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Renato Junqueira","family":"Borges","sequence":"additional","affiliation":[{"name":"Large Animal Veterinary Teaching Hospital, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Galp\u00e3o 4, Granja do Torto, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7327-9143","authenticated-orcid":false,"given":"Isabel Luana de","family":"Mac\u00eado","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Laboratory, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Via L4 Norte, Campus Universit\u00e1rio Darcy Ribeiro, Asa Norte, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davi Emanuel Ribeiro de","family":"Sousa","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Laboratory, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Via L4 Norte, Campus Universit\u00e1rio Darcy Ribeiro, Asa Norte, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3922-1428","authenticated-orcid":false,"given":"Jo\u00e3o Marcelo Azevedo de Paula","family":"Antunes","sequence":"additional","affiliation":[{"name":"Veterinary Hospital, Universidade Federal Rural do Semi-\u00c1rido, BR 110 Km 47 n 572, Mossor\u00f3 59625-900, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-0856","authenticated-orcid":false,"given":"M\u00e1rcio Botelho de","family":"Castro","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Laboratory, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Via L4 Norte, Campus Universit\u00e1rio Darcy Ribeiro, Asa Norte, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Raphael","family":"Teixeira-Neto","sequence":"additional","affiliation":[{"name":"Large Animal Veterinary Teaching Hospital, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Galp\u00e3o 4, Granja do Torto, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-1838","authenticated-orcid":false,"given":"Benito","family":"Soto-Blanco","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinics and Surgery, Veterinary College, Universidade Federal de Minas Gerais, Avenida Presidente Ant\u00f4nio Carlos 6627, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6895-7210","authenticated-orcid":false,"given":"Antonio Carlos Lopes","family":"C\u00e2mara","sequence":"additional","affiliation":[{"name":"Large Animal Veterinary Teaching Hospital, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Galp\u00e3o 4, Granja do Torto, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"ref_1","unstructured":"Mayhew, I.G.J. 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