{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:36:58Z","timestamp":1792103818655,"version":"4.4.0"},"reference-count":25,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vision"],"abstract":"<jats:p>The deep sclerectomy technique was modified to enhance aqueous humor (AH) outflow via the non-trabecular pathway. A pilot study was carried out to assess its safety and effectiveness. Thirty-eight patients were under observation. After superficial scleral flap (4 \u00d7 4 mm), deep scleral layers were divided into three parts by three parallel-to-limbus incisions. Deep sclerectomy without creating a window in the Descemetes\u2019 membrane was carried out in the distal part. A collagen implant was placed under the sclera of the remaining two parts with one end in the intrascleral pool. The third proximal part was excised to expose the uvea and implant. A Nd:YAG laser trabeculotomy at the surgery site was made on postoperative days 7\u201310. Outcome measures were IOP change, use of hypotensive medication(s), complications, and the need for a second surgery. At six months, the mean IOP decreased from 29.1 \u00b1 9.2 mm Hg to 14.0 \u00b1 4.3 mm Hg (p = 1.4 \u00d7 10\u22129); hypotensive medication use reduced from 2.9 \u00b1 0.9 to 0.6 \u00b1 1.0 (p = 1.3 \u00d7 10\u221210); complete success was achieved in 68.4% of cases and partial success was achieved in 31.6% of cases. Intraoperative and postoperative complications were rare and manageable. The OCT of the surgery site revealed the absence of bleb in all cases. Lymphatic vessels with characteristic bicuspid valves in their lumen were detected in conjunctiva near the operation site and over it in 32 patients. IOP decrease in the proposed technique was achieved by activation of the uveolymphatic route of AH outflow.<\/jats:p>","DOI":"10.3390\/vision6010004","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T09:10:36Z","timestamp":1641978636000},"page":"4","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bleb-Independent Glaucoma Surgery to Activate the Uveolymphatic Route of Non-Trabecular Aqueous Humor Outflow: Short-Term Clinical and OCT Results"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5489-4607","authenticated-orcid":false,"given":"Vinod","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Eye Diseases, Medical Institute, RUDN University, 6 Mikluho-Maklaya St., 117198 Moscow, Russia"},{"name":"Centre of Eye Microsurgery \u201cPRO Zrenie\u201d, 1 Gorshina St., 141407 Khimki, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal Abdulmuhsen","family":"Abu Zaalan","sequence":"additional","affiliation":[{"name":"Department of Eye Diseases, Medical Institute, RUDN University, 6 Mikluho-Maklaya St., 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5677-3649","authenticated-orcid":false,"given":"Andrey Igorevich","family":"Bezzabotnov","sequence":"additional","affiliation":[{"name":"Centre of Eye Microsurgery \u201cPRO Zrenie\u201d, 1 Gorshina St., 141407 Khimki, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina Nikolaevna","family":"Dushina","sequence":"additional","affiliation":[{"name":"Department of Eye Diseases, Medical Institute, RUDN University, 6 Mikluho-Maklaya St., 117198 Moscow, Russia"},{"name":"Centre of Eye Microsurgery \u201cPRO Zrenie\u201d, 1 Gorshina St., 141407 Khimki, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Saleh Soliman","family":"Shradqa","sequence":"additional","affiliation":[{"name":"Centre of Eye Microsurgery \u201cPRO Zrenie\u201d, 1 Gorshina St., 141407 Khimki, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarina Shaykuliyevna","family":"Rustamova","sequence":"additional","affiliation":[{"name":"Department of Eye Diseases, Medical Institute, RUDN University, 6 Mikluho-Maklaya St., 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail Aleksandrovich","family":"Frolov","sequence":"additional","affiliation":[{"name":"Department of Eye Diseases, Medical Institute, RUDN University, 6 Mikluho-Maklaya St., 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.exer.2016.01.017","article-title":"Unconventional aqueous humor outflow: A review","volume":"158","author":"Johnson","year":"2017","journal-title":"Exp. 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Russ."}],"container-title":["Vision"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2411-5150\/6\/1\/4\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:27:22Z","timestamp":1760362042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2411-5150\/6\/1\/4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,12]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["vision6010004"],"URL":"https:\/\/doi.org\/10.3390\/vision6010004","relation":{},"ISSN":["2411-5150"],"issn-type":[{"value":"2411-5150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,12]]}}}