{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:00:10Z","timestamp":1788350410925,"version":"build-2803163510"},"reference-count":44,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Waikato Eye Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vision"],"abstract":"<jats:p>Ocular surface squamous neoplasia (OSSN) has a high incidence in the southern hemisphere. This prospective study evaluated the incidence of OSSN in the Waikato region of New Zealand. All patients presenting with pterygium or conjunctival lesions in the Waikato region in 2020 were included. All surgeons in the region were asked to send all conjunctival and corneal specimens excised for histopathologic examination. The primary outcome measure was the incidence of OSSN. Eighty-eight percent of all excised specimens were sent for histopathologic examination. Of the 185 excised lesions sent for histopathological assessment, 18 (10%) were reported as OSSN. Patients were on average 69.4 years of age (standard deviation, SD = 6.9), predominantly male (78%), and of New Zealand-European ethnicity (89%). The OSSN annual incidence was 3.67\/100,000\/year. Histology grades included conjunctival intraepithelial neoplasia (CIN)-I (25%), CIN-II (25%), CIN-III (12.5%), carcinoma in situ (25%), and invasive squamous cell carcinoma (SCC) (12.5%). One patient with invasive SCC required exenteration. This study identified a high incidence rate of OSSN and is the first prospective study to analyze OSSN epidemiology in New Zealand.<\/jats:p>","DOI":"10.3390\/vision6030050","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T03:40:32Z","timestamp":1660621232000},"page":"50","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ocular Surface Squamous Neoplasia: A 12-Month Prospective Evaluation of Incidence in Waikato, New Zealand"],"prefix":"10.3390","volume":"6","author":[{"given":"Ruhella R","family":"Hossain","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1010, New Zealand"},{"name":"Department of Ophthalmology, Hawkes Bay District Health Board, Hastings 4120, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1685-8920","authenticated-orcid":false,"given":"Jee Ah","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1010, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"McLintock","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Waikato District Health Board, Hamilton 3204, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6460-4175","authenticated-orcid":false,"given":"James","family":"McKelvie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1010, New Zealand"},{"name":"Department of Ophthalmology, Waikato District Health Board, Hamilton 3204, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0039-6257(05)80054-2","article-title":"Ocular Surface Squamous Neoplasia","volume":"39","author":"Lee","year":"1995","journal-title":"Surv. 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