{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:34:35Z","timestamp":1787315675991,"version":"build-2736575974"},"reference-count":46,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vision"],"abstract":"<jats:p>Objectives: To assess the decrease in myopia progression and rebound effect using topical low-dose atropine compared to a combined treatment with contact lenses for myopic control. Methods: This retrospective review study included 85 children aged 10.34 \u00b1 2.27 (range 6 to 15.5) who were followed over three years. All had a minimum myopia increase of 1.00 D the year prior to treatment. The children were divided into two treatment groups and a control group. One treatment group included 29 children with an average prescription of 4.81 \u00b1 2.12 D (sphere equivalent (SE) range of 1.25\u201310.87 D), treated with 0.01% atropine for two years (A0.01%). The second group included 26 children with an average prescription of 4.14 \u00b1 1.35 D (SE range of 1.625\u20136.00 D), treated with MiSight 1 day dual focus contact lenses (DFCL) and 0.01% atropine (A0.01% + DFCL) for two years. The control group included 30 children wearing single-vision spectacles (SV), averaging \u22125.06 \u00b1 1.77 D (SE) range 2.37\u20138.87 D). Results: There was an increase in the SE myopia progression in the SV group of 1.19 \u00b1 0.43 D, 1.25 \u00b1 0.52 D, and 1.13 \u00b1 0.36 D in the first, second, and third years, respectively. Myopia progression in the A0.01% group was 0.44 \u00b1 0.21 D (p &lt; 0.01) and 0.51 \u00b1 0.39 D (p &lt; 0.01) in the first and second years, respectively. In the A0.01% + DFCL group, myopia progression was 0.35 \u00b1 0.26 D and 0.44 \u00b1 0.40 D in the first and second years, respectively (p &lt; 0.01). Half a year after the cessation of the atropine treatment, myopia progression (rebound effect) was measured at \u22120.241 \u00b1 0.35 D and \u22120.178 \u00b1 0.34 D in the A0.01% and A0.01% + DFCL groups, respectively. Conclusions: Monotherapy low-dose atropine, combined with peripheral blur contact lenses, was clinically effective in decreasing myopia progression. A low rebound effect was found after the therapy cessation. In this retrospective study, combination therapy did not present an advantage over monotherapy.<\/jats:p>","DOI":"10.3390\/vision6040073","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T03:32:32Z","timestamp":1670902352000},"page":"73","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Low-Concentration Atropine Monotherapy vs. Combined with MiSight 1 Day Contact Lenses for Myopia Management"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3327-0173","authenticated-orcid":false,"given":"Nir","family":"Erdinest","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9574409, Israel"},{"name":"The Myopia Center, Rishon LeZion 4951732, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-3275","authenticated-orcid":false,"given":"Naomi","family":"London","sequence":"additional","affiliation":[{"name":"Naomi Vision Boutique, 5 Even Israel St., Jerusalem 9422805, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itay","family":"Lavy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9574409, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Landau","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9574409, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Ben Ephraim Noyman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rambam Health Care Campus, Haifa 3525408, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadav","family":"Levinger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9574409, Israel"},{"name":"Department of Ophthalmology, Enaim Refractive Surgery Center, Jerusalem 9438307, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair","family":"Morad","sequence":"additional","affiliation":[{"name":"The Myopia Center, Rishon LeZion 4951732, Israel"},{"name":"Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin 7033001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100923","DOI":"10.1016\/j.preteyeres.2020.100923","article-title":"Efficacy in myopia control","volume":"83","author":"Brennan","year":"2021","journal-title":"Prog. 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