{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:54:43Z","timestamp":1787741683066,"version":"build-2784847793"},"reference-count":47,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vision"],"abstract":"<jats:p>(1) Introduction: We analysed epithelial changes after the treatment of moderate myopia with transepithelial photorefractive keratectomy. (2) Materials and Methods: We used optical coherence tomography data and analysed changes in the stroma and epithelium after ablation. We aimed to ascertain how much epithelium hyperplasia occurred after TransPRK; for this, we used data from 50 eyes treated with TransPRK with the AMARIS 1050 Hz, with a minimum follow-up of 4 months. (3) Results: The measured epithelial changes corresponded to a less than 0.1 \u00b1 0.2D of spherical effect, less than 0.2 \u00b1 0.2D of astigmatic effect, and less than 0.5 \u00b1 0.2D of comatic effect. (4) Conclusions: The changes in epithelial thickness after aberration-neutral transepithelial photorefractive keratectomy for moderate myopia were very small, indicating a low level of epithelial hyperplasia without resembling a regression-inducing lentoid.<\/jats:p>","DOI":"10.3390\/vision6040074","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T03:21:52Z","timestamp":1670988112000},"page":"74","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Refractive Effect of Epithelial Remodelling in Myopia after Transepithelial Photorefractive Keratectomy"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9977-5460","authenticated-orcid":false,"given":"Diego","family":"de Ortueta","sequence":"first","affiliation":[{"name":"Aurelios Augenzentrum, 45657 Recklinghausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"von R\u00fcden","sequence":"additional","affiliation":[{"name":"Aurelios Augenzentrum, 45657 Recklinghausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Arba-Mosquera","sequence":"additional","affiliation":[{"name":"SCHWIND Eye-Tech-Solutions, 63801 Kleinostheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1136\/bjo.70.7.482","article-title":"A Comparative Study of Corneal Incisions Induced by Diamond and Steel Knives and Two Ultraviolet Radiations from an Excimer Laser","volume":"70","author":"Marshall","year":"1986","journal-title":"Br. J. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0886-3350(88)80063-4","article-title":"Photorefractive Keratectomy: A Technique for Laser Refractive Surgery","volume":"14","author":"Munnerlyn","year":"1988","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0886-3350(13)80381-1","article-title":"Excimer Laser Intrastromal Keratomileusis: Case Reports","volume":"18","author":"Buratto","year":"1992","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jcrs.2010.07.033","article-title":"Results of Small Incision Lenticule Extraction: All-in-One Femtosecond Laser Refractive Surgery","volume":"37","author":"Shah","year":"2011","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/eye.1993.143","article-title":"Excimer Laser Photorefractive Keratectomy for Myopia: 12 Month Follow-Up","volume":"7","author":"Ficker","year":"1993","journal-title":"Eye"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0886-3350(13)80005-3","article-title":"Excimer Laser Photorefractive Keratectomy with Tapered Transition Zone for High Myopia: A Preliminary Report of Six Cases","volume":"19","author":"Dausch","year":"1993","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0161-6420(94)31371-6","article-title":"Complications of Myopic Photorefractive Keratectomy with the Excimer Laser","volume":"101","author":"Seiler","year":"1994","journal-title":"Ophthalmology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/08820539809059822","article-title":"Regression After LASIK for the Treatment of Myopia: The Role of the Corneal Epithelium","volume":"13","author":"Lohmann","year":"1998","journal-title":"Semin. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3928\/1081597X-20141113-02","article-title":"Rate of Change of Curvature of the Corneal Stromal Surface Drives Epithelial Compensatory Changes and Remodeling","volume":"30","author":"Reinstein","year":"2014","journal-title":"J. Refract. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3928\/1081597X-20190826-03","article-title":"Corneal Epithelial Thickness Mapping After Photorefractive Keratectomy for Myopia","volume":"35","author":"Sedaghat","year":"2019","journal-title":"J. Refract. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3928\/1081-597X-20000301-05","article-title":"Role of the Corneal Epithelium in Refractive Changes Following Laser in Situ Keratomileusis for High Myopia","volume":"16","author":"Spadea","year":"2000","journal-title":"J. Refract. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3928\/1081597X-20140416-01","article-title":"Lenticule Thickness Readout for Small Incision Lenticule Extraction Compared to Artemis Three-Dimensional Very High-Frequency Digital Ultrasound Stromal Measurements","volume":"30","author":"Reinstein","year":"2014","journal-title":"J. Refract. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3928\/1081597X-20200730-03","article-title":"Early Corneal and Epithelial Remodeling Differences Identified by OCT Imaging and Artificial Intelligence Between Two Transepithelial PRK Platforms","volume":"36","author":"Shetty","year":"2020","journal-title":"J. Refract. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3928\/1081597X-20090401-03","article-title":"Comparison of Standard and Aberration-Neutral Profiles for Myopic LASIK with the SCHWIND ESIRIS Platform","volume":"25","author":"Baatz","year":"2009","journal-title":"J. Refract. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2147\/OPTH.S32374","article-title":"Comparison of Single-Step Reverse Transepithelial All-Surface Laser Ablation (ASLA) to Alcohol-Assisted Photorefractive Keratectomy","volume":"6","author":"Aslanides","year":"2012","journal-title":"Clin. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3928\/1081597X-20140903-01","article-title":"JRS Standard for Reporting Astigmatism Outcomes of Refractive Surgery","volume":"30","author":"Reinstein","year":"2014","journal-title":"J. Refract. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3928\/1081597X-20090201-02","article-title":"Aberration-Neutral Ablation Pattern in Hyperopic LASIK with the ESIRIS Laser Platform","volume":"25","author":"Baatz","year":"2009","journal-title":"J. Refract. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3928\/1081597X-20190104-01","article-title":"Longitudinal and Regional Non-Uniform Remodeling of Corneal Epithelium After Topography-Guided FS-LASIK","volume":"35","author":"Fan","year":"2019","journal-title":"J. Refract. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jcrs.2018.02.015","article-title":"Repeatability of Automatic Measurements by a New Anterior Segment Optical Coherence Tomographer Combined with Placido Topography and Agreement with 2 Scheimpflug Cameras","volume":"44","author":"Savini","year":"2018","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3928\/1081597X-20100225-01","article-title":"Topographic Stability after Hyperopic LASIK","volume":"26","year":"2010","journal-title":"J. Refract. Surg."},{"key":"ref_21","unstructured":"(2021, September 29). Available online: https:\/\/www.iso.org\/obp\/ui\/#iso:std:iso:10938:ed-2:v1:en."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3928\/1081597X-20180402-04","article-title":"Transepithelial Photorefractive Keratectomy in Moderate to High Astigmatism With a Non-Wavefront-Guided Aberration-Neutral Ablation Profile","volume":"34","author":"Verma","year":"2018","journal-title":"J. Refract. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ophtha.2007.07.012","article-title":"Five-Year Outcome of LASIK for Myopia","volume":"115","author":"Kato","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_24","first-page":"59","article-title":"Excimer Laser Treatment of Spherical Hyperopia: PRK or LASIK?","volume":"98","author":"Johnston","year":"2000","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3928\/1081-597X-20060201-09","article-title":"Photorefractive Keratectomy and LASIK for the Correction of Hyperopia: 2-Year Follow-Up","volume":"22","author":"Spadea","year":"2006","journal-title":"J. Refract. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/S0161-6420(91)32127-4","article-title":"Changes in Corneal Topography after Excimer Laser Photorefractive Keratectomy for Myopia","volume":"98","author":"Wilson","year":"1991","journal-title":"Ophthalmology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/ICO.0000000000001821","article-title":"Comparison of Corneal Epithelial Remodeling Over 2 Years in LASIK Versus SMILE: A Contralateral Eye Study","volume":"38","author":"Kanellopoulos","year":"2019","journal-title":"Cornea"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3928\/1081597X-20170111-01","article-title":"Comparison of Corneal Epithelial Remodeling After Femtosecond Laser-Assisted LASIK and Small Incision Lenticule Extraction (SMILE)","volume":"33","author":"Ryu","year":"2017","journal-title":"J. Refract. Surg."},{"key":"ref_29","first-page":"166","article-title":"Longitudinal Postoperative Lasik Epithelial Thickness Profile Changes in Correlation with Degree of Myopia Correction","volume":"30","author":"Kanellopoulos","year":"2014","journal-title":"J. Refract. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3928\/1081597X-20090422-07","article-title":"Epithelial Thickness Profile Changes Induced by Myopic LASIK as Measured by Artemis Very High-Frequency Digital Ultrasound","volume":"25","author":"Reinstein","year":"2009","journal-title":"J. Refract. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3928\/1081597X-20170920-02","article-title":"Postoperative Corneal Asphericity in Low, Moderate, and High Myopic Eyes After Transepithelial PRK Using a New Pulse Allocation","volume":"33","author":"Lin","year":"2017","journal-title":"J. Refract. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1364\/BOE.5.001089","article-title":"Spectral OCT with Speckle Contrast Reduction for Evaluation of the Healing Process after PRK and Transepithelial PRK","volume":"5","author":"Kaluzny","year":"2014","journal-title":"Biomed. Opt. Express"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3928\/1081597X-20180618-02","article-title":"Clinical Outcomes of Transepithelial Photorefractive Keratectomy According to Epithelial Thickness","volume":"34","author":"Jun","year":"2018","journal-title":"J. Refract. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.exer.2005.09.021","article-title":"Stromal Haze, Myofibroblasts, and Surface Irregularity after PRK","volume":"82","author":"Netto","year":"2006","journal-title":"Exp. Eye Res."},{"key":"ref_35","first-page":"S199","article-title":"Effect of Decreasing Surface and Interface Irregularities after Photorefractive Keratectomy and Laser in Situ Keratomileusis on Optical and Functional Outcomes","volume":"14","author":"Vinciguerra","year":"1998","journal-title":"J. Refract. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3928\/1081597X-20161122-01","article-title":"Advanced Surface Ablation With a New Software for the Reduction of Ablation Irregularities","volume":"33","author":"Vinciguerra","year":"2017","journal-title":"J. Refract. Surg."},{"key":"ref_37","first-page":"1","article-title":"Mechanisms of Optical Regression Following Corneal Laser Refractive Surgery: Epithelial and Stromal Responses","volume":"7","author":"Moshirfar","year":"2018","journal-title":"Med. Hypothesis Discov. Innov. Ophthalmol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/lsm.1900090603","article-title":"Effect of Excimer Laser Radiant Exposure on Uniformity of Ablated Corneal Surface","volume":"9","author":"Fantes","year":"1989","journal-title":"Lasers Surg. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3928\/1081597X-20130719-02","article-title":"Improved Effectiveness of Transepithelial PTK versus Topography-Guided Ablation for Stromal Irregularities Masked by Epithelial Compensation","volume":"29","author":"Reinstein","year":"2013","journal-title":"J. Refract. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0002-9394(02)01942-6","article-title":"Mathematical Model of Corneal Surface Smoothing after Laser Refractive Surgery","volume":"135","author":"Huang","year":"2003","journal-title":"Am. J. Ophthalmol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.clae.2016.11.004","article-title":"Trans Advanced Surface Laser Ablation (TransPRK) Outcomes Using SmartPulseTechnology","volume":"40","author":"Aslanides","year":"2017","journal-title":"Cont Lens Anterior Eye"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1136\/bjophthalmol-2017-311694","article-title":"Three-Year Outcomes after High Hyperopia Correction Using Photorefractive Keratectomy with a Large Ablation Zone","volume":"103","author":"Kaluzny","year":"2019","journal-title":"Br. J. Ophthalmol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1097\/ICO.0000000000002011","article-title":"Six-Month Outcomes After High Hyperopia Correction Using Laser-Assisted In Situ Keratomileusis With a Large Ablation Zone","volume":"38","author":"Penin","year":"2019","journal-title":"Cornea"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3928\/1081-597X-19930101-10","article-title":"Optics of the Corneal Epithelium","volume":"9","author":"Simon","year":"1993","journal-title":"Refract. Corneal Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.jcrs.2016.05.009","article-title":"Topography of the Corneal Epithelium and Bowman Layer in Low to Moderately Myopic Eyes","volume":"42","author":"Saad","year":"2016","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/112067219700700202","article-title":"Regression and Wound Healing after Excimer Laser PRK: A Histopathological Study on Human Corneas","volume":"7","author":"Lohmann","year":"1997","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0161-6420(00)00142-1","article-title":"Stromal Wound Healing Explains Refractive Instability and Haze Development after Photorefractive Keratectomy: A 1-Year Confocal Microscopic Study","volume":"107","author":"Cavanagh","year":"2000","journal-title":"Ophthalmology"}],"container-title":["Vision"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2411-5150\/6\/4\/74\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:40:27Z","timestamp":1760146827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2411-5150\/6\/4\/74"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":47,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["vision6040074"],"URL":"https:\/\/doi.org\/10.3390\/vision6040074","relation":{},"ISSN":["2411-5150"],"issn-type":[{"value":"2411-5150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]}}}