{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:57:50Z","timestamp":1781020670570,"version":"3.54.1"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vision"],"abstract":"<jats:p>Right temporal variant of frontotemporal dementia (rtv-FTD) represents an uncommon and recently described frontotemporal dementia (FTD) entity presenting with symptoms in many ways comparable to those of the frontal or behavioral variant of FTD (bv-FTD). The aims of this study were to explore the timing of cognitive and behavioral symptoms of rtv-FTD, and to compare the distinct cognitive deficits including prosopagnosia and behavioral symptoms of rtv-FTD patients with those observed in bv-FTD patients. We reviewed the records of 105 patients clinically diagnosed with FTD. A total of 7 patients (5 men\/2 women) with FTD and marked right temporal atrophy in magnetic resonance imaging (MRI) were detected. Clinical features were compared with those observed in a group of 22 age-matched patients (16 men\/6 women) with FTD and predominant frontal lobe atrophy. The main presenting symptoms of rtv-FTD were prosopagnosia, apathy, and episodic memory impairment. In contrast, social awkwardness and compulsive behaviors were dominant in later stages of the disease together with disinhibition and loss of insight with a marked personality change. Although the cognitive and behavioral profiles of patients with right temporal or frontal lobes atrophy present substantial similarities, each subtype has a number of distinct characteristics. It appears that prosopagnosia, obsessive behaviors, and psychotic symptoms are more prominent in rtv-FTD patients.<\/jats:p>","DOI":"10.3390\/vision6040075","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T03:21:52Z","timestamp":1670988112000},"page":"75","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prosopagnosia, Other Specific Cognitive Deficits, and Behavioral Symptoms: Comparison between Right Temporal and Behavioral Variant of Frontotemporal Dementia"],"prefix":"10.3390","volume":"6","author":[{"given":"Christos","family":"Koros","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ion","family":"Beratis","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"},{"name":"Deree-The American College of Greece, 15342 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavroula","family":"Matsi","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3006-8711","authenticated-orcid":false,"given":"Anastasia","family":"Bougea","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Bonakis","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Papatriantafyllou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1426-3384","authenticated-orcid":false,"given":"Efthalia","family":"Angelopoulou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Kapaki","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Stefanis","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-3635","authenticated-orcid":false,"given":"Sokratis G.","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2174\/1567205014666170725130819","article-title":"Frontotemporal Lobar Degeneration (FTLD): Review and Update for Clinical Neurologists","volume":"15","author":"Hernandez","year":"2018","journal-title":"Curr. Alzheimer Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13195-019-0483-2","article-title":"Phenocopy syndrome of behavioral variant frontotemporal dementia: A systematic review","volume":"1","author":"Valente","year":"2019","journal-title":"Alzheimers Res. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1093\/brain\/awp037","article-title":"The clinical profile of right temporal lobe atrophy","volume":"132","author":"Chan","year":"2009","journal-title":"Brain"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cortex.2017.08.024","article-title":"Semantic dementia and the left and right temporal lobes","volume":"107","author":"Snowden","year":"2018","journal-title":"Cortex"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/13554794.2012.732089","article-title":"Neuropsychological, behavioral, and anatomical evolution in right temporal variant frontotemporal dementia: A longitudinal and post-mortem single case analysis","volume":"20","author":"Henry","year":"2014","journal-title":"Neurocase"},{"key":"ref_7","first-page":"8","article-title":"Progress in perceptual research: The case of prosopagnosia","volume":"31","author":"Albonico","year":"2019","journal-title":"F1000Research"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1212\/01.WNL.0000158425.46019.5C","article-title":"The natural history of temporal variant frontotemporal dementia","volume":"64","author":"Seeley","year":"2005","journal-title":"Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1212\/01.WNL.0000091868.28557.B8","article-title":"Left\/right asymmetry of atrophy in semantic dementia: Behavioral-cognitive implications","volume":"61","author":"Thompson","year":"2003","journal-title":"Neurology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1212\/WNL.52.8.1689","article-title":"Assessment of cognition in advanced AD: The test for severe impairment","volume":"52","author":"Jacobs","year":"1999","journal-title":"Neurology"},{"key":"ref_11","first-page":"1696","article-title":"The 5 words: A simple and sensitive test for the diagnosis of Alzheimer\u2019s disease","volume":"31","author":"Dubois","year":"2002","journal-title":"Presse Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s00415-013-7219-1","article-title":"The 5 Objects Test: A novel, minimal-language, memory screening test","volume":"261","author":"Papageorgiou","year":"2014","journal-title":"J. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1212\/WNL.55.11.1621","article-title":"The FAB: A Frontal Assessment Battery at bedside","volume":"55","author":"Dubois","year":"2000","journal-title":"Neurology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia","volume":"44","author":"Cummings","year":"1994","journal-title":"Neurology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1017\/S0317167100021053","article-title":"Frontal behavioral inventory: Diagnostic criteria for frontal lobe dementia","volume":"24","author":"Kertesz","year":"1997","journal-title":"Can. J. Neurol Sci."},{"key":"ref_16","first-page":"637","article-title":"Clinical Dementia Rating (CDR)","volume":"24","author":"Berg","year":"1998","journal-title":"Psychopharmacol. Bull."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","article-title":"Assessment of older people: Self-maintaining and instrumental activities of daily living","volume":"9","author":"Lawton","year":"1969","journal-title":"Gerontologist"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jns.2012.04.002","article-title":"The frontotemporal dementias in a tertiary referral center: Classification and demographic characteristics in a series of 232 cases","volume":"318","author":"Ioannidis","year":"2012","journal-title":"J. Neurol. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1155\/2012\/360965","article-title":"Famous people knowledge and the right and left temporal lobes","volume":"25","author":"Snowden","year":"2012","journal-title":"Behav. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/13554790902971141","article-title":"Right anterior temporal lobe atrophy and person-based semantic defect: A detailed case study","volume":"15","author":"Busigny","year":"2009","journal-title":"Neurocase"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1093\/brain\/awr205","article-title":"eVoice processing in dementia: A neuropsychological and neuroanatomical analysis","volume":"134","author":"Hailstone","year":"2011","journal-title":"Brain"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/13554794.2012.701641","article-title":"Impaired emotion processing from vocal and facial cues in frontotemporal dementia compared to right hemisphere stroke","volume":"19","author":"Dara","year":"2003","journal-title":"Neurocase"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1212\/WNL.56.suppl_4.S11","article-title":"The influence of right frontotemporal dysfunction on social behavior in frontotemporal dementia","volume":"56","author":"Mychack","year":"2001","journal-title":"Neurology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jocn.2011.06.007","article-title":"Right temporal variant frontotemporal dementia with motor neuron disease","volume":"19","author":"Coon","year":"2012","journal-title":"J. Clin. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.jocn.2009.03.005","article-title":"Frontotemporal dementia and motor neurone disease: Overlapping clinic-pathological disorders","volume":"16","author":"Lillo","year":"2012","journal-title":"J. Clin. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1136\/jnnp-2012-302437","article-title":"Episodic memory and the medial temporal lobe: Not all it seems. Evidence from the temporal variants of frontotemporal dementia","volume":"83","author":"Pleizier","year":"2009","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1212\/CPJ.0000000000000429","article-title":"Apathy and functional disability in behavioral variant frontotemporal dementia","volume":"8","author":"Yassuda","year":"2018","journal-title":"Neurol. Clin. Pract."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1093\/brain\/awr173","article-title":"Convergent grey and white matter evidence of orbitofrontal cortex changes related to disinhibition in behavioural variant frontotemporal dementia","volume":"134","author":"Hornberger","year":"2011","journal-title":"Brain"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.nicl.2017.02.001","article-title":"Study Group. Predicting behavioral variant frontotemporal dementia with pattern classification in multi-center structural MRI data","volume":"14","author":"Meyer","year":"2017","journal-title":"Neuroimage Clin."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/brain\/awn343","article-title":"Social conceptual impairments in frontotemporal lobar degeneration with right anterior temporal hypometabolism","volume":"132","author":"Zahn","year":"2009","journal-title":"Brain"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1155\/2012\/286427","article-title":"Apathy in frontotemporal dementia: Behavioral and neuroimaging correlates","volume":"25","author":"Eslinger","year":"2012","journal-title":"Behav Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1212\/01.WNL.0000113729.77161.C9","article-title":"Behavioral disorders in the frontal and temporal variants of frontotemporal dementia","volume":"62","author":"Liu","year":"2004","journal-title":"Neurology"},{"key":"ref_33","first-page":"685","article-title":"Obsessive-compulsive behaviour in two patients with right temporal variant frontotemporal dementia","volume":"56","author":"Sabbe","year":"2014","journal-title":"Tijdschr. Psychiatr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/jnnp.70.3.323","article-title":"Distinct behavioural profiles in frontotemporal dementia and semantic dementia","volume":"70","author":"Snowden","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/01.pra.0000438190.04786.16","article-title":"Frontotemporal dementia mimicking bipolar disorder","volume":"19","author":"Kerstein","year":"2013","journal-title":"J. Psychiatr. Pract."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"102040","DOI":"10.1016\/j.ajp.2020.102040","article-title":"Psychotic symptoms in frontotemporal dementia with right frontotemporal atrophy","volume":"18","author":"Mukku","year":"2020","journal-title":"Asian J. Psychiatr."},{"key":"ref_37","first-page":"195","article-title":"Dietary changes, compulsions and sexual behavior in frontotemporal degeneration","volume":"6","author":"Miller","year":"1995","journal-title":"Dementia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s12031-011-9547-x","article-title":"Eating disturbance in behavioural-variant frontotemporal dementia","volume":"45","author":"Piguet","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1212\/01.wnl.0000277461.06713.23","article-title":"Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia","volume":"69","author":"Woolley","year":"2007","journal-title":"Neurology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1136\/jnnp-2014-309120","article-title":"Differentiating between right-lateralised semantic dementia and behavioural-variant frontotemporal dementia: An examination of clinical characteristics and emotion processing","volume":"86","author":"Kamminga","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1212\/WNL.0b013e3181bf9945","article-title":"Two distinct subtypes of right temporal variant frontotemporal dementia","volume":"73","author":"Josephs","year":"2009","journal-title":"Neurology"}],"container-title":["Vision"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2411-5150\/6\/4\/75\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:40:39Z","timestamp":1760146839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2411-5150\/6\/4\/75"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["vision6040075"],"URL":"https:\/\/doi.org\/10.3390\/vision6040075","relation":{},"ISSN":["2411-5150"],"issn-type":[{"value":"2411-5150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]}}}