{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:52:00Z","timestamp":1784749920994,"version":"3.55.0"},"reference-count":33,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vision"],"abstract":"<jats:p>The clinical characteristics of three types of optic neuritis (double seronegative optic neuritis; DN-ON, Neuromyelitis optica spectrum disorder-related optic neuritis; NMOSD-ON, and multiple sclerosis-related optic neuritis; MS-ON) were examined in order to identify factors that may affect good visual recovery in Thai patients. The study included patients diagnosed with three types of optic neuritis at Rajavithi Hospital between 2011 and 2020. Visual acuity at the end of 12 months was used as the treatment outcome. Multiple logistic regression analysis was used to evaluate potential predictors of good visual recovery. Of the 76 patients, 61 had optic neuritis, with DN-ON as the most common subtype (52.6%). MS-ON patients were significantly younger (28.3 \u00b1 6.6 years, p = 0.002) and there was a female predominance in all subgroups (p = 0.076). NMOSD-ON patients had a significantly higher proportion of poor baseline VA (p &lt; 0.001). None of the NMOSD-ON patients achieved 0.3 logMAR visual recovery in the 12-month period (p = 0.022). A delay in treatment with intravenous methylprednisolone (IVMP) for more than 7 days increased the risk of failure to gain 0.3 logMAR visual recovery by five times (OR 5.29, 95% CI 1.359\u201320.616, p = 0.016), with NMOSD-ON as the strongest predictor (OR 10.47, 95% CI; 1.095\u201399.993, p = 0.041). Early treatment with intravenous methylprednisolone may be important for achieving at least 0.3 logMAR visual recovery in Thai patients with optic neuritis.<\/jats:p>","DOI":"10.3390\/vision7010016","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T06:09:52Z","timestamp":1677564592000},"page":"16","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A 10-Year Single-Center Study of the Clinical Characteristics of Optic Neuritis-Related NMOSD, MS, and Double Seronegative Optic Neuritis, Together with Factors Predicting Visual Outcomes"],"prefix":"10.3390","volume":"7","author":[{"given":"Parinee","family":"Kemchoknatee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Rajavithi Hospital, Rangsit University, 2 Phaya Thai Rd., Thung Phaya Thai, Ratchathewi, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chotika","family":"Singhakul","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rajavithi Hospital, Rangsit University, 2 Phaya Thai Rd., Thung Phaya Thai, Ratchathewi, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4707-2530","authenticated-orcid":false,"given":"Niracha","family":"Arjkongharn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rajavithi Hospital, Rangsit University, 2 Phaya Thai Rd., Thung Phaya Thai, Ratchathewi, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Methaphon","family":"Chainakul","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rajavithi Hospital, Rangsit University, 2 Phaya Thai Rd., Thung Phaya Thai, Ratchathewi, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duanghathai","family":"Tangon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Rajavithi Hospital, Rangsit University, 2 Phaya Thai Rd., Thung Phaya Thai, Ratchathewi, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-9590","authenticated-orcid":false,"given":"Thansit","family":"Srisombut","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rajavithi Hospital, Rangsit University, 2 Phaya Thai Rd., Thung Phaya Thai, Ratchathewi, Bangkok 10400, Thailand"},{"name":"Faculty of Medicine Rajavithi Hospital, Rangsit University, 2 Phaya Thai Rd., Thung Phaya Thai, Ratchathewi, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJM199202273260901","article-title":"A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. 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