{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:18:47Z","timestamp":1776723527891,"version":"3.51.2"},"reference-count":47,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T00:00:00Z","timestamp":1678492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Eunice Kennedy-Shriver National Institute of Child Health &amp; Human Development (NICHD)","award":["# U54HD071594"],"award-info":[{"award-number":["# U54HD071594"]}]},{"name":"Eunice Kennedy-Shriver National Institute of Child Health &amp; Human Development (NICHD)","award":["EIN 262145011"],"award-info":[{"award-number":["EIN 262145011"]}]},{"name":"The Alicia and Madu Rao Translational Research Foundation","award":["# U54HD071594"],"award-info":[{"award-number":["# U54HD071594"]}]},{"name":"The Alicia and Madu Rao Translational Research Foundation","award":["EIN 262145011"],"award-info":[{"award-number":["EIN 262145011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vision"],"abstract":"<jats:p>Extremely low gestational-age neonates requiring supplemental oxygen experience intermittent hypoxia (IH) episodes, which predispose them to oxidative stress and retinopathy of prematurity. We tested the hypothesis that early supplementation with fish oil or CoQ10 confers benefits reducing the severity of IH-induced retinopathy. At birth, rat pups were exposed to two clinically relevant neonatal IH paradigms with recovery in either hyperoxia (50% O2) or room air (RA) between episodes for 14 days, during which they received daily oral fish oil, coenzyme Q10 (CoQ10) in olive oil (OO), or OO only (vehicle). At postnatal day 14 (P14), pups were allowed to recover in RA with no further treatment until P21. Retinas were examined at P14 and at P21. Both IH paradigms resulted in severe ocular oxidative stress and retinopathy regardless of recovery in hyperoxia or RA in the vehicle groups. Although early supplementation with fish oil was beneficial, CoQ10 provided superior benefits for reducing IH-induced oxidative stress and retinopathy. These effects were associated with lower retinal antioxidants and biomarkers of angiogenesis. The therapeutic benefits of CoQ10 suggest a potential treatment for IH-induced retinopathies. Further studies are needed to establish appropriate, safe, and effective doses for use in preterm infants.<\/jats:p>","DOI":"10.3390\/vision7010020","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T03:03:57Z","timestamp":1678676637000},"page":"20","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Coenzyme Q10 and Fish Oil Supplementation for Reducing Retinal Oxidative Stress in a Rat Model"],"prefix":"10.3390","volume":"7","author":[{"given":"Faisal","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Health Sciences University, Brooklyn, NY 11203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, State University of New York, Downstate Health Sciences University, Brooklyn, NY 11203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob V.","family":"Aranda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Health Sciences University, Brooklyn, NY 11203, USA"},{"name":"Department of Ophthalmology, State University of New York, Downstate Health Sciences University, Brooklyn, NY 11203, USA"},{"name":"State University of New York Eye Institute, Brooklyn, NY 11203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4129-475X","authenticated-orcid":false,"given":"Kay D.","family":"Beharry","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Health Sciences University, Brooklyn, NY 11203, USA"},{"name":"Department of Ophthalmology, State University of New York, Downstate Health Sciences University, Brooklyn, NY 11203, USA"},{"name":"State University of New York Eye Institute, Brooklyn, NY 11203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"153e","DOI":"10.1542\/neo.2-7-e153","article-title":"Retinopathy of Prematurity: History, Classification, and Pathophysiology","volume":"2","author":"Phelps","year":"2001","journal-title":"NeoReviews"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"78F","DOI":"10.1136\/fn.87.2.F78","article-title":"Retinopathy of prematurity: Recent advances in our understanding","volume":"87","author":"Wheatley","year":"2002","journal-title":"Arch. 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