{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:16:36Z","timestamp":1787030196228,"version":"build-2736575974"},"reference-count":44,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"EPSRC","doi-asserted-by":"publisher","award":["EP\/M006255\/1"],"award-info":[{"award-number":["EP\/M006255\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sir John Fisher Foundation","award":["EP\/M006255\/1"],"award-info":[{"award-number":["EP\/M006255\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vision"],"abstract":"<jats:p>Studies demonstrated impairment in the control of saccadic eye movements in Alzheimer\u2019s disease (AD) and people with mild cognitive impairment (MCI) when conducting the pro-saccade and antisaccade tasks. Research showed that changes in the pro and antisaccade latencies may be particularly sensitive to dementia and general executive functioning. These tasks show potential for diagnostic use, as they provide a rich set of potential eye tracking markers. One such marker, the coefficient of variation (CV), is so far overlooked. For biological markers to be reliable, they must be able to detect abnormalities in preclinical stages. MCI is often viewed as a predecessor to AD, with certain classifications of MCI more likely than others to progress to AD. The current study examined the potential of CV scores on pro and antisaccade tasks to distinguish participants with AD, amnestic MCI (aMCI), non-amnesiac MCI (naMCI), and older controls. The analyses revealed no significant differences in CV scores across the groups using the pro or antisaccade task. Antisaccade mean latencies were able to distinguish participants with AD and the MCI subgroups. Future research is needed on CV measures and attentional fluctuations in AD and MCI individuals to fully assess this measure\u2019s potential to robustly distinguish clinical groups with high sensitivity and specificity.<\/jats:p>","DOI":"10.3390\/vision7020038","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T12:12:11Z","timestamp":1682943131000},"page":"38","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Eye Movement Latency Coefficient of Variation as a Predictor of Cognitive Impairment: An Eye Tracking Study of Cognitive Impairment"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1813-0765","authenticated-orcid":false,"given":"Megan","family":"Polden","sequence":"first","affiliation":[{"name":"Department of Primary Care & Mental Health, University of Liverpool, Liverpool L3 5TR, UK"},{"name":"Health Research, Lancaster University, Lancaster LA1 4YW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5928-7307","authenticated-orcid":false,"given":"Trevor J.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Psychology Department, Lancaster University, Lancaster LA1 4YW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"590986","DOI":"10.3389\/fpsyg.2021.590986","article-title":"Contribution of Eye-Tracking to Study Cognitive Impairments Among Clinical Populations","volume":"12","author":"Wolf","year":"2021","journal-title":"Front. Psychol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Liu, Z., Yang, Z., Gu, Y., Liu, H., and Wang, P. (2021). The effectiveness of eye tracking in the diagnosis of cognitive disorders: A systematic review and meta-analysis. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0254059"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1123456","DOI":"10.3389\/fnagi.2023.1123456","article-title":"Early detection of cognitive decline in Alzheimer\u2019s disease using eye tracking","volume":"15","author":"Tokushige","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Akkoyun, M., Ko\u00e7o\u011flu, K., Boz, H.E., Keskino\u011flu, P., and Akdal, G. (2023). Saccadic Eye Movements in Patients with Mild Cognitive Impairment: A Longitudinal Study. J. Mot. Behav., 1\u201319.","DOI":"10.1080\/00222895.2023.2202620"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11065-021-09495-3","article-title":"Saccadic Eye Movement in Mild Cognitive Impairment and Alzheimer\u2019s Disease: A Systematic Review and Meta-Analysis","volume":"32","author":"Opwonya","year":"2022","journal-title":"Neuropsychol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Readman, M.R., Polden, M., Gibbs, M.C., Wareing, L., and Crawford, T.J. (2021). The Potential of Naturalistic Eye Movement Tasks in the Diagnosis of Alzheimer\u2019s Disease: A Review. Brain Sci., 11.","DOI":"10.3390\/brainsci11111503"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-141173","article-title":"Eye movements in Alzheimer\u2019s disease","volume":"44","author":"Molitor","year":"2015","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/WCO.0000000000000274","article-title":"Eye movements in neurodegenerative diseases","volume":"29","author":"MacAskill","year":"2016","journal-title":"Curr. Opin. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2217\/nmt.12.73","article-title":"Alzheimer\u2019s disease: Is the clue in the eyes?","volume":"3","author":"Crawford","year":"2013","journal-title":"Neurodegener. Dis. Manag."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1142\/S0219635215500090","article-title":"Diagnosis of mild Alzheimer disease through the analysis of eye movements during reading","volume":"14","author":"Castro","year":"2015","journal-title":"J. Integr. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1469-8986.2006.00403.x","article-title":"The antisaccade task as a research tool in psychopathology: A critical review","volume":"43","author":"Hutton","year":"2006","journal-title":"Psychophysiology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuroimage.2017.10.001","article-title":"Age related prefrontal compensatory mechanisms for inhibitory control in the antisaccade task","volume":"165","author":"Peltsch","year":"2018","journal-title":"Neuroimage"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nrn1345","article-title":"Look away: The anti-saccade task and the voluntary control of eye movement","volume":"5","author":"Munoz","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s11357-012-9466-y","article-title":"The role of working memory and attentional disengagement on inhibitory control: Effects of aging and Alzheimer\u2019s disease","volume":"35","author":"Crawford","year":"2013","journal-title":"Age"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/brain\/124.8.1492","article-title":"Attentional control in Alzheimer\u2019s disease","volume":"124","author":"Baddeley","year":"2001","journal-title":"Brain"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1111\/ejn.12617","article-title":"Saccade deficits in amnestic mild cognitive impairment resemble mild Alzheimer\u2019s disease","volume":"39","author":"Peltsch","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s11357-012-9420-z","article-title":"Specific saccade deficits in patients with Alzheimer\u2019s disease at mild to moderate stage and in patients with amnestic mild cognitive impairment","volume":"35","author":"Yang","year":"2012","journal-title":"Age"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000333080","article-title":"Long Latency and High Variability in Accuracy-Speed of Prosaccades in Alzheimer\u2019s Disease at Mild to Moderate Stage","volume":"1","author":"Yang","year":"2011","journal-title":"Dement. Geriatr. Cogn. Disord. Extra"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Polden, M., Wilcockson, T.D., and Crawford, T.J. (2020). The disengagement of visual attention: An eye-tracking study of cognitive impairment, ethnicity and age. Brain Sci., 10.","DOI":"10.3390\/brainsci10070461"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cortex.2021.05.016","article-title":"Active visual inhibition is preserved in the presence of a distracter: A cross-cultural, ageing and dementia study","volume":"142","author":"Polden","year":"2021","journal-title":"Cortex"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00221-010-2488-8","article-title":"Is the relationship of prosaccade reaction times and antisaccade errors mediated by working memory?","volume":"208","author":"Crawford","year":"2010","journal-title":"Exp. Brain Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J. Intern. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/gps.5385","article-title":"Clinical utility of mild cognitive impairment subtypes and number of impaired cognitive domains at predicting progression to dementia: A 20-year retrospective study","volume":"36","author":"Glynn","year":"2020","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1212\/01.wnl.0000252358.03285.9d","article-title":"Conversion from subtypes of mild cognitive impairment to Alzheimer dementia","volume":"68","author":"Fischer","year":"2007","journal-title":"Neurology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000354370","article-title":"Rate of conversion from prodromal Alzheimer\u2019s disease to Alzheimer\u2019s dementia: A systematic review of the literature","volume":"3","author":"Ward","year":"2013","journal-title":"Dement. Geriatr. Cogn. Disord. Extra"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/13803395.2021.1900077","article-title":"Deficits in saccadic eye movements differ between subtypes of patients with mild cognitive impairment","volume":"43","author":"Hodgson","year":"2021","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.18632\/aging.102118","article-title":"Abnormalities of saccadic eye movements in dementia due to Alzheimer\u2019s disease and mild cognitive impairment","volume":"11","author":"Wilcockson","year":"2019","journal-title":"Aging"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bandc.2008.08.021","article-title":"Cognitive control of saccadic eye movements","volume":"68","author":"Hutton","year":"2008","journal-title":"Brain Cogn."},{"key":"ref_30","first-page":"295","article-title":"Preservation of automatic ocular saccades in healthy elderly: Alteration in patients with dementia with Lewy body","volume":"8","author":"Kapoula","year":"2010","journal-title":"Psychol. Neuropsychiatr. Vieil."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/jnp.12048","article-title":"The free and cued selective reminding test: Validation for mild cognitive impairment and A lzheimer\u2019s disease","volume":"9","author":"Lemos","year":"2015","journal-title":"J. Neuropsychol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool for Mild Cognitive Impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_33","unstructured":"Wechsler, D. (1997). WAiS-iii, Psychological Corporation."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1080\/01688639708403750","article-title":"Free and cued selective reminding and selective reminding in the elderly","volume":"19","author":"Grober","year":"1997","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.mcna.2013.01.001","article-title":"International Work Group Criteria for the Diagnosis of Alzheimer Disease","volume":"97","author":"Cummings","year":"2013","journal-title":"Med. Clin. N. Am."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Mardanbegi, D., Wilcockson, T., Sawyer, P., Gellersen, H., and Crawford, T. (2019, January 25\u201328). SaccadeMachine: Software for analyzing saccade tests (anti-saccade and pro-saccade). Proceedings of the 11th ACM Symposium on Eye Tracking Research & Applications, Denver, CO, USA.","DOI":"10.1145\/3317956.3318148"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1001\/archneurol.2011.1021","article-title":"Saccade abnormalities in au-topsy-confirmed frontotemporal lobar degeneration and Alzheimer disease","volume":"69","author":"Boxer","year":"2012","journal-title":"Arch. Neurol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/brb3.28","article-title":"Executive deficits detected in mild Alzheimer\u2019s disease using the antisaccade task","volume":"2","author":"Kaufman","year":"2012","journal-title":"Brain Behav."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pneurobio.2015.06.006","article-title":"Visual attention: Linking prefrontal sources to neuronal and behavioral correlates","volume":"132","author":"Clark","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.copsyc.2018.11.002","article-title":"Impairments of attention in Alzheimer\u2019s disease","volume":"29","author":"Malhotra","year":"2019","journal-title":"Curr. Opin. Psychol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1037\/0894-4105.18.3.580","article-title":"Selective attention impairments in Alzheimer\u2019s disease: Evidence for dissociable components","volume":"18","author":"Levinoff","year":"2004","journal-title":"Neuropsychology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.21037\/atm-20-7214","article-title":"Temporal dynamic changes of intrinsic brain activity in Alzheimer\u2019s disease and mild cognitive impairment patients: A resting-state functional magnetic resonance imaging study","volume":"9","author":"Li","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.1523\/JNEUROSCI.0549-06.2006","article-title":"Medial Versus Lateral Frontal Lobe Contributions to Voluntary Saccade Control as Revealed by the Study of Patients with Frontal Lobe Degeneration","volume":"26","author":"Boxer","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1093\/brain\/awn047","article-title":"Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer\u2019s disease","volume":"131","author":"Garbutt","year":"2008","journal-title":"Brain"}],"container-title":["Vision"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2411-5150\/7\/2\/38\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:27:47Z","timestamp":1760124467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2411-5150\/7\/2\/38"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,1]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["vision7020038"],"URL":"https:\/\/doi.org\/10.3390\/vision7020038","relation":{},"ISSN":["2411-5150"],"issn-type":[{"value":"2411-5150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,1]]}}}