{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:04:59Z","timestamp":1792249499669,"version":"4.4.0"},"reference-count":66,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/NEI","award":["R01EY031731"],"award-info":[{"award-number":["R01EY031731"]}]},{"name":"NIH\/NEI","award":["1UL1TR003098"],"award-info":[{"award-number":["1UL1TR003098"]}]},{"name":"University of Maryland","award":["R01EY031731"],"award-info":[{"award-number":["R01EY031731"]}]},{"name":"University of Maryland","award":["1UL1TR003098"],"award-info":[{"award-number":["1UL1TR003098"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vision"],"abstract":"<jats:p>Background: To investigate the repeatability in vessel caliber measurements by optical coherence tomography angiography (OCTA). Methods: In this prospective study, 28 patients (47 eyes) underwent sequential OCTA imaging of the optic nerve head and macula. Two independent masked graders measured vessel caliber for sequential images of the optic nerve head and macula. The average vessel width was determined and variability between graders and images. Results: A total of 8400 measurements of 420 vessels from 84 OCTA images were included in the analysis. Overall, inter-grader agreement was excellent (ICC 0.90). The coefficient of variation (CoV) for all repeated OCTA images was 0.10. Greater glaucoma severity, older age, macular location, and diagnosis of diabetes were associated with thinner vessels (p &lt; 0.05). CoV was higher in the peripapillary region (0.07) as compared to the macula (0.15). ICC was high for all subgroups except for the macula (ICC = 0.72). Conclusions: Overall, the repeatability of vessel caliber measurements by OCTA was high and variability low. There was greater variability in the measurement of macular vessels, possibly due to technical limitations in acquiring accurate vessel widths for smaller macular vessels.<\/jats:p>","DOI":"10.3390\/vision7030048","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T01:42:47Z","timestamp":1688434967000},"page":"48","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTA"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1155-049X","authenticated-orcid":false,"given":"Joby","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Broward Health, Deerfield Beach, FL 33064, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Asanad","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Whiting","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Magder","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3082-4604","authenticated-orcid":false,"given":"Osamah","family":"Saeedi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9380","DOI":"10.1038\/s41598-018-27536-5","article-title":"Distinct Retinal Capillary Plexuses in Normal Eyes as Observed in Optical Coherence Tomography Angiography Axial Profile Analysis","volume":"8","author":"Hirano","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0002-9394(01)00871-6","article-title":"Optic nerve blood flow is diminished in eyes of primary open-angle glaucoma suspects","volume":"132","author":"Grunwald","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1001\/archophthalmol.2010.347","article-title":"Retinal vessel diameter as a clinical predictor of diabetic retinopathy progression: Time to take out the measuring tape","volume":"129","author":"Wong","year":"2011","journal-title":"Arch. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1001\/jamaophthalmol.2015.5658","article-title":"Automated Quantification of Capillary Nonperfusion Using Optical Coherence Tomography Angiography in Diabetic Retinopathy","volume":"134","author":"Hwang","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ajo.2018.08.001","article-title":"Advanced Optical Coherence Tomography Angiography Analysis of Age-related Macular Degeneration Complicated by Onset of Unilateral Choroidal Neovascularization","volume":"195","author":"Arrigo","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1167\/iovs.16-19570","article-title":"Swept-Source OCT Angiography Imaging of the Foveal Avascular Zone and Macular Capillary Network Density in Diabetic Retinopathy","volume":"57","author":"Akil","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1167\/iovs.18-24168","article-title":"An Optical Coherence Tomography Angiography Study of the Relationship between Foveal Avascular Zone Size and Retinal Vessel Density","volume":"59","author":"Kwon","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2515841420950508","DOI":"10.1177\/2515841420950508","article-title":"OCTA in neurodegenerative optic neuropathies: Emerging biomarkers at the eye-brain interface","volume":"12","author":"Asanad","year":"2020","journal-title":"Ther. Adv. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2515841419840249","DOI":"10.1177\/2515841419840249","article-title":"An overview of optical coherence tomography angiography and the posterior pole","volume":"11","author":"Onishi","year":"2019","journal-title":"Ther. Adv. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1001\/archophthalmol.2010.340","article-title":"Retinal venular diameter as an early indicator of progression to proliferative diabetic retinopathy with and without high-risk characteristics in African Americans with type 1 diabetes mellitus","volume":"129","author":"Roy","year":"2011","journal-title":"Arch. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.1111\/aos.13156","article-title":"Assessment of retinal vascular calibres as a biomarker of disease activity in birdshot chorioretinopathy","volume":"95","author":"Agrawal","year":"2017","journal-title":"Acta Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0002-9394(01)01315-0","article-title":"Reliability of retinal photography in the assessment of retinal microvascular characteristics: The Atherosclerosis Risk in Communities Study","volume":"133","author":"Couper","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000342158","article-title":"Retinal vascular caliber measurements: Clinical significance, current knowledge and future perspectives","volume":"229","author":"Ikram","year":"2013","journal-title":"Ophthalmologica"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7998","DOI":"10.1167\/iovs.13-12318","article-title":"Absolute retinal blood flow measurement with a dual-beam Doppler optical coherence tomography","volume":"54","author":"Dai","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/aos.12553","article-title":"Retinal hemodynamic oxygen reactivity assessed by perfusion velocity, blood oximetry and vessel diameter measurements","volume":"93","author":"Klefter","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5862","DOI":"10.1167\/iovs.18-25423","article-title":"The Relationship between Peripapillary Vascular Density and Visual Field Sensitivity in Primary Open-Angle and Angle-Closure Glaucoma","volume":"59","author":"Jo","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00417-014-2715-2","article-title":"Retinal vessel diameter measurements by spectral domain optical coherence tomography","volume":"253","author":"Ouyang","year":"2015","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kromer, R., Buhmann, C., Hidding, U., Keseru, M., Keseru, D., Hassenstein, A., and Stemplewitz, B. (2016). Evaluation of Retinal Vessel Morphology in Patients with Parkinson\u2019s Disease Using Optical Coherence Tomography. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161136"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1167\/iovs.13-13621","article-title":"Retinal vessel diameter assessment in papilledema by semi-automated analysis of SLO images: Feasibility and reliability","volume":"55","author":"Moss","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/eye.1994.19","article-title":"Vessel diameter changes during the cardiac cycle","volume":"8","author":"Chen","year":"1994","journal-title":"Eye"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3109\/02713689609008902","article-title":"The accurate assessment of changes in retinal vessel diameter using multiple frame electrocardiograph synchronised fundus photography","volume":"15","author":"Dumskyj","year":"1996","journal-title":"Curr. Eye Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1136\/bjophthalmol-2016-309678","article-title":"Retinal vessel calibre measurements by optical coherence tomography angiography","volume":"101","author":"Darvizeh","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5799","DOI":"10.1167\/iovs.11-9326","article-title":"Does retinal vascular geometry vary with cardiac cycle?","volume":"53","author":"Hao","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/bjo.88.1.57","article-title":"Variation associated with measurement of retinal vessel diameters at different points in the pulse cycle","volume":"88","author":"Knudtson","year":"2004","journal-title":"Br. J. Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1076\/ceyr.27.3.143.16049","article-title":"Revised formulas for summarizing retinal vessel diameters","volume":"27","author":"Knudtson","year":"2003","journal-title":"Curr. Eye Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e269","DOI":"10.1111\/j.1755-3768.2011.02374.x","article-title":"Retinal vessel diameter can reliably be determined in minipigs using Retinal Vessel Analyser with a microscope-mounted fundus camera","volume":"90","author":"Papadopoulou","year":"2012","journal-title":"Acta Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1442-9071.2002.00520.x","article-title":"Reliability of computer-assisted retinal vessel measurementin a population","volume":"30","author":"Sherry","year":"2002","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000446843","article-title":"Computer-Assisted Evaluation of Retinal Vessel Diameter in Retinitis Pigmentosa","volume":"56","author":"Sodi","year":"2016","journal-title":"Ophthalmic Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/opo.12223","article-title":"Retinal vessel oxygen saturation and vessel diameter in high myopia","volume":"35","author":"Zheng","year":"2015","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1111\/aos.12519","article-title":"Diabetic macular ischaemia is associated with narrower retinal arterioles in patients with type 2 diabetes","volume":"93","author":"Liew","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"ref_31","first-page":"1258","article-title":"Measurement of retinal blood vessel width using computerized image analysis","volume":"29","author":"Eaton","year":"1988","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Turgut, B. (2016). Optical coherence tomography angiography\u2014A general view. J. Opt. Coherence Tomogr. Angiogr.\u2014Gen. View, in press.","DOI":"10.17925\/EOR.2016.10.01.39"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1097\/IAE.0000000000000765","article-title":"Image Artifacts in Optical Coherence Tomography Angiography","volume":"35","author":"Spaide","year":"2015","journal-title":"Retina"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/jamaophthalmol.2017.3431","article-title":"Repeatability and Reproducibility of Superficial Macular Retinal Vessel Density Measurements Using Optical Coherence Tomography Angiography En Face Images","volume":"135","author":"Lei","year":"2017","journal-title":"JAMA Ophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"66008","DOI":"10.1117\/1.JBO.21.6.066008","article-title":"Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography","volume":"21","author":"Chu","year":"2016","journal-title":"J. Biomed. Opt."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9632647","DOI":"10.1155\/2017\/9632647","article-title":"Retinal Vessel Density in Optical Coherence Tomography Angiography in Optic Atrophy after Nonarteritic Anterior Ischemic Optic Neuropathy","volume":"2017","author":"Liu","year":"2017","journal-title":"J. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1002\/sim.5466","article-title":"Sample size formulas for estimating intraclass correlation coefficients with precision and assurance","volume":"31","author":"Zou","year":"2012","journal-title":"Stat. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1167\/iovs.15-18904","article-title":"Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography","volume":"57","author":"Kim","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Pastore, M.R., Grotto, A., Vezzoni, F., Gaggino, A., Milan, S., Gouigoux, S., Guerin, P.L., Vinciguerra, A.L., Cirigliano, G., and Tognetto, D. (2022). Reproducibility and Reliability of Spectralis II OCT Angiography Vascular Measurements. Diagnostics, 12.","DOI":"10.3390\/diagnostics12081908"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1167\/iovs.15-18476","article-title":"Measurement of Retinal Vascular Caliber from Optical Coherence Tomography Phase Images","volume":"57","author":"Fondi","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_41","first-page":"407","article-title":"Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography","volume":"31","author":"Zhao","year":"2018","journal-title":"Biomed. Environ. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/tvst.8.3.6","article-title":"Repeatability of Wide-field Optical Coherence Tomography Angiography in Normal Retina","volume":"8","author":"Eastline","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_43","unstructured":"(2022, May 08). Spectralis OCT Angiography Module to Be Presented at AAO. Available online: www.heidelbergengineering.com\/int\/press-releases\/spectralis-oct-angiography-module-to-be-presented-at-aao\/."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1442-9071.2007.01627.x","article-title":"Retinal vessel diameter in normal and glaucomatous eyes: The Beijing eye study","volume":"35","author":"Wang","year":"2007","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_45","first-page":"1599","article-title":"Parapapillary retinal vessel diameter in normal and glaucoma eyes. I. Morphometric data","volume":"30","author":"Jonas","year":"1989","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0002-9394(01)01200-4","article-title":"Association of retinal vessel caliber and visual field defects in glaucoma","volume":"132","author":"Hall","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.1167\/iovs.08-2142","article-title":"Evidence of retinal vascular narrowing in glaucomatous eyes in an Asian population","volume":"49","author":"Amerasinghe","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1001\/archopht.122.1.76","article-title":"The relation of retinal vessel caliber to the incidence and progression of diabetic retinopathy: XIX: The Wisconsin Epidemiologic Study of Diabetic Retinopathy","volume":"122","author":"Klein","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.2337\/dc10-2419","article-title":"Retinal vascular geometry predicts incident retinopathy in young people with type 1 diabetes: A prospective cohort study from adolescence","volume":"34","author":"Craig","year":"2011","journal-title":"Diabetes Care"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1097\/OPX.0b013e3182775c62","article-title":"Blood pressure, vessel caliber, and retinal thickness in diabetes","volume":"89","author":"Harrison","year":"2012","journal-title":"Optom. Vis. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1167\/iovs.03-0079","article-title":"Retinal vessel diameters and their associations with age and blood pressure","volume":"44","author":"Wong","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Akil, H., Huang, A.S., Francis, B.A., Sadda, S.R., and Chopra, V. (2017). Retinal vessel density from optical coherence tomography angiography to differentiate early glaucoma, pre-perimetric glaucoma and normal eyes. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170476"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Golebiewska, J., Olechowski, A., Wysocka-Mincewicz, M., Odrobina, D., Baszynska-Wilk, M., Groszek, A., Szalecki, M., and Hautz, W. (2017). Optical coherence tomography angiography vessel density in children with type 1 diabetes. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186479"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ajo.2017.07.011","article-title":"Progressive Macula Vessel Density Loss in Primary Open-Angle Glaucoma: A Longitudinal Study","volume":"182","author":"Shoji","year":"2017","journal-title":"Am. J. Ophthalmol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1167\/iovs.15-18944","article-title":"Optical Coherence Tomography Angiography Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes","volume":"57","author":"Yarmohammadi","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1016\/j.ophtha.2016.08.041","article-title":"Relationship between Optical Coherence Tomography Angiography Vessel Density and Severity of Visual Field Loss in Glaucoma","volume":"123","author":"Yarmohammadi","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1001\/jamaophthalmol.2017.0080","article-title":"Quantification of Retinal Microvascular Density in Optical Coherence Tomographic Angiography Images in Diabetic Retinopathy","volume":"135","author":"Durbin","year":"2017","journal-title":"JAMA Ophthalmol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.ophtha.2017.06.002","article-title":"Projection-Resolved Optical Coherence Tomography Angiography of Macular Retinal Circulation in Glaucoma","volume":"124","author":"Takusagawa","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1167\/iovs.17-22865","article-title":"Optical Coherence Tomography Angiography Macular and Peripapillary Vessel Perfusion Density in Healthy Subjects, Glaucoma Suspects, and Glaucoma Patients","volume":"58","author":"Triolo","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1586\/17469899.2014.975796","article-title":"Autoregulation of optic nerve head blood flow and its role in open-angle glaucoma","volume":"9","author":"Jones","year":"2014","journal-title":"Expert Rev. Ophthalmol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1364\/BOE.3.003264","article-title":"Direct visualization and characterization of erythrocyte flow in human retinal capillaries","volume":"3","author":"Bedggood","year":"2012","journal-title":"Biomed. Opt. Express"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1038\/s41598-017-02344-5","article-title":"Reactivity in the human retinal microvasculature measured during acute gas breathing provocations","volume":"7","author":"Duan","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"014002","DOI":"10.1117\/1.2166434","article-title":"Evaluating the lateral resolution of the adaptive optics scanning laser ophthalmoscope","volume":"11","author":"Zhang","year":"2006","journal-title":"J. Biomed. Opt."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4103\/0301-4738.126185","article-title":"Adaptive optics imaging of the retina","volume":"62","author":"Battu","year":"2014","journal-title":"Indian J. Ophthalmol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.2147\/OPTH.S96529","article-title":"Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes","volume":"10","author":"Cheng","year":"2016","journal-title":"Clin. Ophthalmol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/09286586.2017.1409360","article-title":"Pupil Dilation May Affect Retinal Vessel Caliber Measures","volume":"25","author":"Wang","year":"2018","journal-title":"Ophthalmic Epidemiol."}],"container-title":["Vision"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2411-5150\/7\/3\/48\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:05:16Z","timestamp":1760126716000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2411-5150\/7\/3\/48"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,3]]},"references-count":66,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["vision7030048"],"URL":"https:\/\/doi.org\/10.3390\/vision7030048","relation":{},"ISSN":["2411-5150"],"issn-type":[{"value":"2411-5150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,3]]}}}