{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:28:56Z","timestamp":1760149736380,"version":"build-2065373602"},"reference-count":69,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vision"],"abstract":"<jats:p>A surgical technique was developed to enhance aqueous humor (AH) flow through the non-trabecular outflow pathway by rerouting it from the anterior chamber (AC) to the suprachoroidal space (SCS) without detaching the ciliary body from the scleral spur. Medium- and long-term surgical outcomes were retrospectively analyzed in a case series of 58 glaucoma patients. At 6, 12, and 24 months, the mean IOP decreased from 27.8 \u00b1 8.3 to 14.9 \u00b1 5.0 mmHg, median 15.0 (25th percentile (p25)13.0; 75th percentile (p75) 18.0) and 15.2 \u00b1 3.3 mmHg, and hypotensive medication use reduced from a median (p25; p75) of 3 (2; 3) to 0 (0; 2), 0 (0; 2), and 0 (0; 1.5), respectively. Intra- and postoperative complications were few and manageable. Following surgery, no bleb formation occurred in any of the cases (as confirmed by optical coherence tomography). Conjunctival lymphatic vessels (CLVs) developed in 50% of eyes (29\/58). Clinically, they developed directly from sclera and had no connection to the surgical site. Analysis further showed that the development of CLVs and their longer visibility period had poor prognostic value for IOP control. If the fluid flow from the SCS to CLVs was resistance-free, no CLV development was evident. However, if any resistance existed in the flow, the fluid accumulated in lymphatics, resulting in their engorgement. The proposed technique was safe and effective in decreasing IOP in glaucoma patients by enhancing AH flow from the SCS to CLVs via connecting intrascleral microchannels.<\/jats:p>","DOI":"10.3390\/vision7030059","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T10:26:43Z","timestamp":1693909603000},"page":"59","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Optical Coherence Tomography Evidence of Aqueous Humor Flow from the Suprachoroidal Space to Conjunctival Lymphatics"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5489-4607","authenticated-orcid":false,"given":"Vinod","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Eye Diseases, Medical Institute, Peoples\u2019 Friendship University of Russia Named after Patrice Lumumba, 6 Mikluho-Maklaya St., 117198 Moscow, Russia"},{"name":"Centre of Eye Microsurgery \u201cPRO Zrenie\u201d, 1 Gorshina Str., 141407 Khimki, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5677-3649","authenticated-orcid":false,"given":"Andrey Igorevich","family":"Bezzabotnov","sequence":"additional","affiliation":[{"name":"Centre of Eye Microsurgery \u201cPRO Zrenie\u201d, 1 Gorshina Str., 141407 Khimki, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarina Shaykuliyevna","family":"Rustamova","sequence":"additional","affiliation":[{"name":"Department of Eye Diseases, Medical Institute, Peoples\u2019 Friendship University of Russia Named after Patrice Lumumba, 6 Mikluho-Maklaya St., 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina Nikolaevna","family":"Dushina","sequence":"additional","affiliation":[{"name":"Department of Eye Diseases, Medical Institute, Peoples\u2019 Friendship University of Russia Named after Patrice Lumumba, 6 Mikluho-Maklaya St., 117198 Moscow, Russia"},{"name":"Centre of Eye Microsurgery \u201cPRO Zrenie\u201d, 1 Gorshina Str., 141407 Khimki, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal Abdulmuhsen","family":"Abu Zaalan","sequence":"additional","affiliation":[{"name":"Centre of Eye Microsurgery \u201cPRO Zrenie\u201d, 1 Gorshina Str., 141407 Khimki, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Saleh Soliman","family":"Shradqa","sequence":"additional","affiliation":[{"name":"Centre of Eye Microsurgery \u201cPRO Zrenie\u201d, 1 Gorshina Str., 141407 Khimki, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail Aleksandrovich","family":"Frolov","sequence":"additional","affiliation":[{"name":"Department of Eye Diseases, Medical Institute, Peoples\u2019 Friendship University of Russia Named after Patrice Lumumba, 6 Mikluho-Maklaya St., 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.exer.2016.01.017","article-title":"Unconventional aqueous humor outflow: A review","volume":"158","author":"Johnson","year":"2017","journal-title":"Exp. 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