{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:23:08Z","timestamp":1760145788022,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vision"],"abstract":"<jats:p>Optic Atrophy (OA) can be associated with the development of microcystic macular edema (MME) in the perifoveal retinal inner nuclear layer (INL). We aimed here to retrospectively determine the prevalence of MME in patients with non-glaucomatous OA in our tertiary ophthalmology department between 2015 and 2020. We then examined how MME affected the thicknesses of the different retinal layers and the differences in demographic and clinical characteristics between those patients who developed MME and those who did not. A total of 643 eyes (429 patients) were included (mean age 45.9 \u00b1 17.8 years, 52% female). MME developed in 95 (15%) eyes and across all etiologies of OA except for toxic\/nutritional causes, but the prevalence of MME varied between the different etiologies. The development of MME was associated with thinning of the ganglion cell layer (11.0 vs. 9.6 \u03bcm; p = 0.001) and the retinal nerve fiber layer (10.1 vs. 9.15 \u03bcm; p = 0.024), with INL thickening in the 3- and 6-mm diameter areas of the central fovea. Patients developing MME had significantly worse distance best-corrected visual acuity than those not developing MME (0.62 vs. 0.38 logMAR; p = 0.002). Overall, the presence of MME in OA cannot be used to guide the diagnostic work-up of OA.<\/jats:p>","DOI":"10.3390\/vision8030052","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T03:22:46Z","timestamp":1725592966000},"page":"52","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microcystic Macular Edema Caused by Non-Glaucomatous Optic Atrophy: A Single-Center, Retrospective, Cohort Study in France"],"prefix":"10.3390","volume":"8","author":[{"given":"Tibaut","family":"Coutureau","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Pierre-Paul Riquet Hospital, Toulouse University Hospital, 31059 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Butterworth","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Pierre-Paul Riquet Hospital, Toulouse University Hospital, 31059 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0569-629X","authenticated-orcid":false,"given":"Damien","family":"Biotti","sequence":"additional","affiliation":[{"name":"Department of Neurology, Toulouse University Hospital, 31059 Toulouse, France"},{"name":"Toulouse Institute for Infectious and Inflammatory Diseases, INSERM U1043, CNRS UMR 5282, 31024 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9224-2351","authenticated-orcid":false,"given":"Pierre","family":"Fourni\u00e9","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Pierre-Paul Riquet Hospital, Toulouse University Hospital, 31059 Toulouse, France"},{"name":"Faculty of Medicine, University of Toulouse III, 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Soler","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Pierre-Paul Riquet Hospital, Toulouse University Hospital, 31059 Toulouse, France"},{"name":"Faculty of Medicine, University of Toulouse III, 31400 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0107-447X","authenticated-orcid":false,"given":"Fanny","family":"Varenne","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Pierre-Paul Riquet Hospital, Toulouse University Hospital, 31059 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/0002-9394(79)90565-8","article-title":"A Clinicopathologic Study of Autosomal Dominant Optic Atrophy","volume":"88","author":"Johnston","year":"1979","journal-title":"Am. 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