{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:29:24Z","timestamp":1765880964845,"version":"3.48.0"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vision"],"abstract":"<jats:p>Background: To evaluate the short-term effects of a dietary supplement containing curcumin, bromelain, glucosamine, chondroitin sulphate, sodium hyaluronate, type II collagen, and vitamin C on symptomatic vitreous floaters (SVFs) following Nd:YAG laser capsulotomy. Methods: Forty eyes with SVFs on the first postoperative day were randomized into a control group (standard topical therapy, n = 20) and a treatment group (oral supplement plus standard therapy, n = 20). Outcomes included best-corrected visual acuity (BCVA), contrast sensitivity (CS), and subjective scores from a non-standardized questionnaire on floater perception (QS1), interference with daily activities (QS2), and foreign body sensation (QS3). Objective evaluation was performed using two novel ultrasound-based methods: mean number of vitreous peaks (MVP) from A-scans and mean grey intensity (MGI) from B-scan images processed with ImageJ. Results: At 2 months, the treatment group showed greater improvement in CS (\u0394 = 0.26 LogCS, CI, 0.14\u20130.38; p &lt; 0.01), QS1 (\u0394 = 1.10; 95% CI, 0.60\u20131.60; p &lt; 0.01), QS2 (\u0394 = 0.90; 95% CI, 0.40\u20131.40; p &lt; 0.01), QS3 (\u0394 = 0.90; 95% CI, 0.44\u20131.36; p &lt; 0.01), MVP (\u0394 = 1.10; 95% CI, 0.60\u20131.60; p &lt; 0.01), and MGI (\u0394 = 12.89 units; 95% CI, 7.84\u201317.93; p &lt; 0.01). BCVA was comparable between groups (p = 0.478). Conclusions: Short-term dietary supplementation with vitreous-specific nutrients is well tolerated and associated with improvements in reducing SVFs and foreign body sensations after Nd:YAG capsulotomy and may represent a promising non-invasive therapeutic option.<\/jats:p>","DOI":"10.3390\/vision9040098","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T09:57:24Z","timestamp":1765879044000},"page":"98","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Curcumin-Based Supplement for Vitreous Floaters Post-Nd:YAG Capsulotomy: A Pilot Study"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7857-6768","authenticated-orcid":false,"given":"Alex","family":"Malandrini","sequence":"first","affiliation":[{"name":"Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-3666","authenticated-orcid":false,"given":"Giovanni","family":"Rubegni","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0217-1957","authenticated-orcid":false,"given":"Davide","family":"Marini","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Spadavecchia","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Marco","family":"Tosi","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/sj.eye.6702661","article-title":"Effect of posterior capsular opacification on visual function in patients with monofocal and multifocal intraocular lenses","volume":"22","author":"Elgohary","year":"2008","journal-title":"Eye"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/s41433-022-02204-1","article-title":"The Royal College of Ophthalmologists\u2019 National Ophthalmology Database study of cataract surgery: Report 9, Risk factors for posterior capsule opacification","volume":"37","author":"Donachie","year":"2023","journal-title":"Eye"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"P1","DOI":"10.1016\/j.ophtha.2016.09.027","article-title":"Cataract in the Adult Eye Preferred Practice Pattern\u00ae","volume":"124","author":"Olson","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1159\/000525335","article-title":"Visually Disturbing Vitreous Floaters following Neodymium-Doped Yttrium Aluminum Garnet Capsulotomy: A Single-Center Case Series","volume":"13","author":"Sim","year":"2022","journal-title":"Case Rep. 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