{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:48:20Z","timestamp":1775026100206,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2007,5,26]],"date-time":"2007-05-26T00:00:00Z","timestamp":1180137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>We report the determination of phenolic compounds in olive leaves by reversed-phase HPLC\/DAD, and the evaluation of their in vitro activity against several microorganisms that may be causal agents of human intestinal and respiratory tract infections, namely Gram positive (Bacillus cereus, B. subtilis and Staphylococcus aureus), Gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae) and fungi (Candida albicans and Cryptococcus neoformans). Seven phenolic compounds were identified and quantified: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-O-glucoside and luteolin 4\u2019-O-glucoside. At low concentrations olive leafs extracts showed an unusual combined antibacterial and antifungal action, which suggest their great potential as nutraceuticals, particulalry as a source of phenolic compounds.<\/jats:p>","DOI":"10.3390\/12051153","type":"journal-article","created":{"date-parts":[[2008,10,25]],"date-time":"2008-10-25T13:32:11Z","timestamp":1224941531000},"page":"1153-1162","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":416,"title":["Phenolic Compounds and Antimicrobial Activity of Olive (Olea europaea L. Cv. Cobran\u00e7osa) Leaves"],"prefix":"10.3390","volume":"12","author":[{"given":"Ana Paula","family":"Pereira","sequence":"first","affiliation":[{"name":"CIMO \/ Escola Superior Agr\u00e1ria, Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus Sta Apol\u00f3nia, Apt. 1172, 5301-855 Bragan\u00e7a, Portugal"}]},{"given":"Isabel CFR","family":"Ferreira","sequence":"additional","affiliation":[{"name":"CIMO \/ Escola Superior Agr\u00e1ria, Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus Sta Apol\u00f3nia, Apt. 1172, 5301-855 Bragan\u00e7a, Portugal"}]},{"given":"Filipa","family":"Marcelino","sequence":"additional","affiliation":[{"name":"CIMO \/ Escola Superior Agr\u00e1ria, Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus Sta Apol\u00f3nia, Apt. 1172, 5301-855 Bragan\u00e7a, Portugal"}]},{"given":"Patricia","family":"Valent\u00e3o","sequence":"additional","affiliation":[{"name":"REQUIMTE \/ Servi\u00e7o de Farmacognosia, Faculdade de Farm\u00e1cia da Universidade do Porto, Rua An\u00edbal Cunha, 164, 4050-047 Porto, Portugal"}]},{"given":"Paula B","family":"Andrade","sequence":"additional","affiliation":[{"name":"REQUIMTE \/ Servi\u00e7o de Farmacognosia, Faculdade de Farm\u00e1cia da Universidade do Porto, Rua An\u00edbal Cunha, 164, 4050-047 Porto, Portugal"}]},{"given":"Rosa","family":"Seabra","sequence":"additional","affiliation":[{"name":"REQUIMTE \/ Servi\u00e7o de Farmacognosia, Faculdade de Farm\u00e1cia da Universidade do Porto, Rua An\u00edbal Cunha, 164, 4050-047 Porto, Portugal"}]},{"given":"Leticia","family":"Estevinho","sequence":"additional","affiliation":[{"name":"CIMO \/ Escola Superior Agr\u00e1ria, Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus Sta Apol\u00f3nia, Apt. 1172, 5301-855 Bragan\u00e7a, Portugal"}]},{"given":"Albino","family":"Bento","sequence":"additional","affiliation":[{"name":"CIMO \/ Escola Superior Agr\u00e1ria, Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus Sta Apol\u00f3nia, Apt. 1172, 5301-855 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2260-0600","authenticated-orcid":false,"given":"Jos\u00e9 Alberto","family":"Pereira","sequence":"additional","affiliation":[{"name":"CIMO \/ Escola Superior Agr\u00e1ria, Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus Sta Apol\u00f3nia, Apt. 1172, 5301-855 Bragan\u00e7a, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2007,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ejlt.200300769","article-title":"Supplementation of oils with oleanolic acid from the olive leaf (Olea europaea)","volume":"106","author":"Guinda","year":"2004","journal-title":"Eur. 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