{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:48:44Z","timestamp":1761238124150,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T00:00:00Z","timestamp":1409788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Factor binding IST-1 (FBI-1) plays an important role in oncogenic transformation and tumorigenesis. As FBI-1 is over-expressed in multiple human cancers, the regulation of itself would provide new effective options for cancer intervention. In this work, we aimed to study the role that EPAS-1 plays in regulating FBI-1. We use the fact that specificity protein-1 (SP-1) is one of the crucial transcription factors of FBI-1, and that SP-1 can interact with the endothelial pas domain protein-1 (EPAS-1) for the induction of hypoxia related genes. The study showed that EPAS-1 plays an indispensible role in SP-1 transcription factor-mediated FBI-1 induction, and participated in tumor cell survival and proliferation. Thus, EPAS-1 could be a novel target for cancer therapeutics.<\/jats:p>","DOI":"10.3390\/ijms150915689","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T03:35:44Z","timestamp":1410147344000},"page":"15689-15699","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["EPAS-1 Mediates SP-1-Dependent FBI-1 Expression and Regulates Tumor Cell Survival and Proliferation"],"prefix":"10.3390","volume":"15","author":[{"given":"Xiaogang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Institute of Neurology,  General Hospital of Shenyang Military Area Command, Shenyang 110016, China"}]},{"given":"Peng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Neurology,  General Hospital of Shenyang Military Area Command, Shenyang 110016, China"}]},{"given":"Zhiqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Neurology,  General Hospital of Shenyang Military Area Command, Shenyang 110016, China"}]},{"given":"Dongyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Neurology,  General Hospital of Shenyang Military Area Command, Shenyang 110016, China"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Fourth Military Medical University, Xi'an 710032, China"}]},{"given":"Guobiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Neurology,  General Hospital of Shenyang Military Area Command, Shenyang 110016, China"}]}],"member":"1968","published-online":{"date-parts":[[2014,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1128\/MCB.17.7.3786","article-title":"Purification and characterization of FBI-1, a cellular factor that binds to the human immunodeficiency virus type 1 inducer of short transcripts","volume":"17","author":"Pessler","year":"1997","journal-title":"Mol. 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