{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:57:32Z","timestamp":1765886252510,"version":"build-2065373602"},"reference-count":65,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT\/MCTES","award":["UIDB\/00690\/2020"],"award-info":[{"award-number":["UIDB\/00690\/2020"]}]},{"DOI":"10.13039\/501100001871","name":"FCT","doi-asserted-by":"publisher","award":["SFRH\/BD\/146614\/2019"],"award-info":[{"award-number":["SFRH\/BD\/146614\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"TRANSCoLAB","award":["0612_TRANS_CO_LAB_2_P"],"award-info":[{"award-number":["0612_TRANS_CO_LAB_2_P"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Agronomy"],"abstract":"<jats:p>Cardoon is a multi-purpose crop with several industrial applications, while the heads (capitula) are edible and commonly used in various dishes of the Mediterranean diet. Several reports in the literature study the chemical composition of the various plants parts (leaves, flower stalks, bracts, seeds) aiming to industrial applications of crop bio-waste, whereas for the heads, most of the studies are limited to the chemical composition and bioactive properties at the edible stage. In the present study, cardoon heads were collected at six different maturation stages and their chemical composition was evaluated in order to determine the effect of harvesting stage and examine the potential of alternative uses in the food and nutraceutical industries. Lipidic fraction and the content in fatty acids, tocopherols, organic acids, and free sugars were determined. Lipidic content decreases with the maturation process, while 22 fatty acids were detected in total, with palmitic, oleic, and linoleic acids being those with the highest abundance depending on harvesting time. In particular, immature heads have a higher abundance in saturated fatty acids (SFA), whereas the samples of mature heads were the richest in monounsaturated fatty acids (MUFA). The \u03b1-tocopherol was the only isoform detected being present in higher amounts in sample Car B (619 \u00b5g\/100 g dw). Oxalic, quinic, malic, citric and fumaric acids were the detected organic acids, and the higher content was observed in sample Car E (15.7 g\/100 g dw). The detected sugars were fructose, glucose, sucrose, trehalose and raffinose, while the highest content (7.4 g\/100 g dw) was recorded in sample Car C. In conclusion, the maturation stage of cardoon heads influences their chemical composition and harvesting time could be a useful means to increase the quality and the added value of the final product by introducing this material in the food and nutraceutical industries.<\/jats:p>","DOI":"10.3390\/agronomy10081088","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T10:16:49Z","timestamp":1595931409000},"page":"1088","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Chemical Composition of Cynara Cardunculus L. var. altilis Heads: The Impact of Harvesting Time"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6494-2326","authenticated-orcid":false,"given":"Filipa","family":"Mandim","sequence":"first","affiliation":[{"name":"Mountain Research Center (CIMO), Polytechnic Institute of Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"The Polyphenols Research Group (GIP-USAL), Faculty of pharmacy, University of Salamanca, Campus Miguel de Umaamuno s\/n, 37007 Salamanca, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0324-7960","authenticated-orcid":false,"given":"Spyridon A.","family":"Petropoulos","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Crop Production and Rural Environment, University of Thessaly, N. Iona, 38446 Volos, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0157-9873","authenticated-orcid":false,"given":"\u00c2ngela","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Mountain Research Center (CIMO), Polytechnic Institute of Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6592-5299","authenticated-orcid":false,"given":"Celestino","family":"Santos-Buelga","sequence":"additional","affiliation":[{"name":"The Polyphenols Research Group (GIP-USAL), Faculty of pharmacy, University of Salamanca, Campus Miguel de Umaamuno s\/n, 37007 Salamanca, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-4882","authenticated-orcid":false,"given":"Isabel C. F. R.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Mountain Research Center (CIMO), Polytechnic Institute of Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-5189","authenticated-orcid":false,"given":"Lillian","family":"Barros","sequence":"additional","affiliation":[{"name":"Mountain Research Center (CIMO), Polytechnic Institute of Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.biombioe.2018.01.001","article-title":"Cynara cardunculus L. as a biomass and multi-purpose crop: A review of 30 years of research","volume":"109","author":"Gominho","year":"2018","journal-title":"Biomass Bioenergy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"103937","DOI":"10.1016\/j.jff.2020.103937","article-title":"Cynara cardunculus L.: Outgoing and potential trends of phytochemical, industrial, nutritive and medicinal merits","volume":"69","author":"Zayed","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s11101-015-9428-y","article-title":"Artichoke: Botanical, agronomical, phytochemical, and pharmacological overview","volume":"14","author":"Incerti","year":"2015","journal-title":"Phytochem. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.tifs.2019.02.015","article-title":"Edible flowers as functional food: A review on artichoke (Cynara cardunculus L.)","volume":"86","author":"Gostin","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"112395","DOI":"10.1016\/j.indcrop.2020.112395","article-title":"Ultrasound assisted extraction of cynaropicrin from Cynara cardunculus leaves: Optimization using the response surface methodology and the effect of pulse mode","volume":"150","author":"Paulino","year":"2020","journal-title":"Ind. Crops Prod."},{"key":"ref_6","first-page":"576","article-title":"Milk-clotting properties of plant rennets and their enzymatic rheological, and sensory role in cheese making: A review","volume":"28","author":"Amira","year":"2017","journal-title":"Int. J. Food Prop."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.idairyj.2018.09.010","article-title":"Characterization of Cynara cardunculus L. flower from Alentejo as a coagulant agent for cheesemaking","volume":"91","author":"Gomes","year":"2019","journal-title":"Int. Dairy J."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-Moreno, N., Cimminelli, M.J., Volpe, F., Ans\u00f3, R., Esparza, I., M\u00e1rmol, I., Rodr\u00edguez-Yoldi, M.J., and Anc\u00edn-Azpilicueta, C. (2019). Phenolic composition of Artichoke waste and its antioxidant capacity on differentiated Caco-2 cells. Nutrients, 11.","DOI":"10.3390\/nu11081723"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.indcrop.2017.07.037","article-title":"Pappi of cardoon (Cynara cardunculus L.): The use of wetting during the harvesting aimed at recovering for the biorefinery","volume":"108","author":"Pari","year":"2017","journal-title":"Ind. Crops Prod."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.eja.2015.09.014","article-title":"Yields and quality of Cynara cardunculus L. wild and cultivated cardoon genotypes. A case study from a marginal land in Central Italy","volume":"72","author":"Francaviglia","year":"2016","journal-title":"Eur. J. Agron."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biombioe.2015.03.009","article-title":"Biomass production of four Cynara cardunculus clones and lignin composition analysis","volume":"76","author":"Neiva","year":"2015","journal-title":"Biomass Bioenergy"},{"key":"ref_12","first-page":"73","article-title":"Cynara cardunculus: Use in cheesemaking and pharmaceutical applications","volume":"Volume 1","author":"Martins","year":"2016","journal-title":"Technological Approaches for Novel Applications in Dairy Processing"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"D\u2019Antuono, I., Carola, A., Sena, L.M., Linsalata, V., Cardinali, A., Logrieco, A.F., Colucci, M.G., and Apone, F. (2018). Artichoke polyphenols produce skin anti-age effects by improving endothelial cell integrity and functionality. Molecules, 23.","DOI":"10.3390\/molecules23112729"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4951937","DOI":"10.1155\/2017\/4951937","article-title":"Chemicals compositions, antioxidant and anti-inflammatory activity of Cynara scolymus leaves extracts, and analysis of major bioactive polyphenols by HPLC","volume":"2017","author":"Salem","year":"2017","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.indcrop.2017.09.033","article-title":"Cynara scolymus L.: A promising Mediterranean extract for topical anti-aging prevention","volume":"109","author":"Marques","year":"2017","journal-title":"Ind. Crops Prod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1007\/s00253-018-9032-3","article-title":"Cardoon-based rennets for cheese production","volume":"102","author":"Almeida","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tifs.2019.11.015","article-title":"Feeding the skin: A new trend in food and cosmetics convergence","volume":"95","author":"Ascenso","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.foodchem.2018.06.081","article-title":"Phenolic profile and bioactivity of cardoon (Cynara cardunculus L.) inflorescence parts: Selecting the best genotype for food applications","volume":"268","author":"Dias","year":"2018","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"109281","DOI":"10.1016\/j.foodres.2020.109281","article-title":"Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis","volume":"134","author":"Mandim","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.jff.2013.09.001","article-title":"Choice of time of harvest influences the polyphenol profile of globe artichoke","volume":"5","author":"Pandino","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.indcrop.2018.12.005","article-title":"Antimicrobial activity of cultivated cardoon (Cynara cardunculus L. var. altilis DC.) leaf extracts against bacterial species of agricultural and food interest","volume":"129","author":"Scavo","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.plaphy.2020.01.006","article-title":"The effect of developmental and environmental factors on secondary metabolites in medicinal plants","volume":"148","author":"Li","year":"2020","journal-title":"Plant. Physiol. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"126838","DOI":"10.1016\/j.foodchem.2020.126838","article-title":"Chemical composition and in vitro biological activities of cardoon (Cynara cardunculus L. var. altilis DC.) seeds as influenced by viability","volume":"323","author":"Mandim","year":"2020","journal-title":"Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.foodchem.2017.11.082","article-title":"Influence of the ripening stage and the lyophilization of wild cardoon flowers on their chemical composition, enzymatic activities of extracts and technological properties of cheese curds","volume":"245","author":"Blecker","year":"2018","journal-title":"Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.lwt.2014.12.050","article-title":"Chemical characterization and use of artichoke parts for protection from oxidative stress in canola oil","volume":"61","author":"Claus","year":"2015","journal-title":"LWT Food Sci. Technol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1744-7348.2009.00384.x","article-title":"Phenological growth stages of Cynara cardunculus: Codification and description according to the BBCH scale","volume":"156","author":"Archontoulis","year":"2013","journal-title":"Ann. Appl. B"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpls.2018.00459","article-title":"Nutritional value and bioactive compounds characterization of plant parts from Cynara cardunculus L. (Asteraceae) cultivated in central Greece","volume":"9","author":"Petropoulos","year":"2018","journal-title":"Front. Plant. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/j.jff.2013.07.019","article-title":"Bioactivity and chemical characterization in hydrophilic and lipophilic compounds of Chenopodium ambrosioides L.","volume":"5","author":"Barros","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1039\/C8FO01910J","article-title":"Calluna vulgaris (L.) Hull: Chemical characterization, evaluation of its bioactive properties and effect on the vaginal microbiota","volume":"10","author":"Mandim","year":"2019","journal-title":"Food Funct."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.lwt.2015.01.034","article-title":"Nutritional parameters of infusions and decoctions obtained from Fragaria vesca L. roots and vegetative parts","volume":"62","author":"Dias","year":"2015","journal-title":"LWT Food Sci. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1039\/C4FO00210E","article-title":"Bioactivity and phytochemical characterization of Arenaria Montana L.","volume":"5","author":"Pereira","year":"2014","journal-title":"Food Funct."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"125713","DOI":"10.1016\/j.foodchem.2019.125713","article-title":"The bioactive profile of lettuce produced in a closed soilless system as configured by combinatorial effects of genotype and macrocation supply composition","volume":"309","author":"Petropoulos","year":"2020","journal-title":"Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.indcrop.2018.08.027","article-title":"How extraction method affects yield, fatty acids composition and bioactive properties of cardoon seed oil?","volume":"124","author":"Petropoulos","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.foodchem.2017.01.159","article-title":"Nutritional value and chemical composition of Greek artichoke genotypes","volume":"267","author":"Petropoulos","year":"2018","journal-title":"Food Chem."},{"key":"ref_35","first-page":"1927","article-title":"Nutritional and metabolic profiling of the globe artichoke (Cynara scolymus L. \u201cCapuanella\u201d heads) in province of caserta, Italy","volume":"7","author":"Dosi","year":"2013","journal-title":"Aust. J. Crop. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.foodchem.2019.03.066","article-title":"Bioactivities, chemical composition and nutritional value of Cynara cardunculus L. seeds","volume":"289","author":"Petropoulos","year":"2019","journal-title":"Food Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.supflu.2012.03.012","article-title":"Biodiesel obtained from supercritical carbon dioxide oil of Cynara cardunculus L.","volume":"68","author":"Alexandre","year":"2012","journal-title":"J. Supercrit. Fluids"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1016\/j.biombioe.2011.04.047","article-title":"Genetic variability in Cynara cardunculus L. domestic and wild types for grain oil production and fatty acids composition","volume":"35","author":"Raccuia","year":"2011","journal-title":"Biomass Bioenergy"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8420","DOI":"10.1021\/jf402253a","article-title":"Lipophilic extracts of Cynara cardunculus L. var. altilis (DC): A source of valuable bioactive terpenic compounds","volume":"61","author":"Ramos","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1039\/C7FO00356K","article-title":"Leaf parts from Greek artichoke genotypes as a good source of bioactive compounds and antioxidants","volume":"8","author":"Petropoulos","year":"2017","journal-title":"Food Funct."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jnutbio.2016.02.010","article-title":"Protective role of n6\/n3 PUFA supplementation with varying DHA\/EPA ratios against atherosclerosis in mice","volume":"32","author":"Liu","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.biombioe.2010.01.018","article-title":"Cynara cardunculus L. genotypes as a crop for energy purposes in a Mediterranean environment","volume":"34","author":"Ierna","year":"2010","journal-title":"Biomass Bioenergy"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jfca.2010.04.010","article-title":"Profile of polyphenols and phenolic acids in bracts and receptacles of globe artichoke (Cynara cardunculus var. scolymus) germplasm","volume":"24","author":"Pandino","year":"2011","journal-title":"J. Food Compos. Anal."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.foodchem.2007.09.005","article-title":"Antioxidant and antimicrobial activity of Cynara cardunculus extracts","volume":"107","author":"Popovic","year":"2008","journal-title":"Food Chem."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Petropoulos, S.A., Fernandes, \u00c2., Dias, M.I., Vasilakoglou, I.B., Petrotos, K., Barros, L., and Ferreira, I.C.F.R. (2019). Nutritional value, chemical composition and cytotoxic properties of common purslane (Portulaca oleracea L.) in relation to harvesting stage and plant part. Antioxidants, 8.","DOI":"10.3390\/antiox8080293"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.foodres.2019.01.052","article-title":"Rubus ulmifolius Schott fruits: A detailed study of its nutritional, chemical and bioactive properties","volume":"119","author":"Pereira","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.indcrop.2018.03.038","article-title":"Pattern recognition of cardoon oil from different large-scale field trials","volume":"118","author":"Gominho","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.fcr.2006.11.006","article-title":"Biomass and grain oil yields in Cynara cardunculus L. genotypes grown in a Mediterranean environment","volume":"101","author":"Raccuia","year":"2007","journal-title":"Field Crops Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0926-6690(99)00027-8","article-title":"Possible alternative utilization of Cynara spp. II. Chemical characterization of their grain oil","volume":"10","author":"Maccarone","year":"1999","journal-title":"Ind. Crops Prod."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"108651","DOI":"10.1016\/j.foodres.2019.108651","article-title":"Valorisation of the green waste parts from turnip, radish and wild cardoon: Nutritional value, phenolic profile and bioactivity evaluation","volume":"126","author":"Chihoub","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tifs.2018.02.006","article-title":"Edible halophytes of the Mediterranean basin: Potential candidates for novel food products","volume":"74","author":"Petropoulos","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Petropoulos, S.A., Fernandes, \u00c2., Dias, M.I., Pereira, C., Calhelha, R.C., Chrysargyris, A., Tzortzakis, N., Ivanov, M., Sokovic, M.D., and Barros, L. (2020). Chemical composition and plant growth of Centaurea raphanina subsp. mixta plants cultivated under saline conditions. Molecules, 25.","DOI":"10.3390\/molecules25092204"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1007\/s12161-014-9795-9","article-title":"Analytical tools used to distinguish chemical profiles of plants widely consumed as infusions and dietary supplements: Artichoke, milk thistle, and borututu","volume":"7","author":"Pereira","year":"2014","journal-title":"Food Anal. Methods"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1002\/ptr.6174","article-title":"Artichoke leaf extract, as AKR1B1 inhibitor, decreases sorbitol level in the rat eye lenses under high glucose conditions ex vivo","volume":"32","year":"2018","journal-title":"Phyther. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/ptr.5774","article-title":"Artichoke Leaf Extract Inhibits AKR1B1 and Reduces NF-\u03baB Activity in Human Leukemic Cells","volume":"31","year":"2017","journal-title":"Phyther. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1021\/jf1045552","article-title":"Determination of free inositols and other low molecular weight carbohydrates in vegetables","volume":"59","author":"Sanz","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/19476337.2012.700951","article-title":"Qualitative and healthy traits of different Italian typical artichoke genotypes","volume":"11","author":"Nicoletto","year":"2013","journal-title":"CyTA J. Food"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/jsfa.7784","article-title":"Effect of nitrogen fertilization on the overall quality of minimally processed globe artichoke heads","volume":"97","author":"Lombardo","year":"2017","journal-title":"J. Sci. Food Agric."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/ijfs.12422","article-title":"Effect of harvest time and geographical area on sensory and instrumental texture profile of a PDO artichoke","volume":"49","author":"Fadda","year":"2014","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/jsfa.3948","article-title":"Changes in inulin and soluble sugar concentration in artichokes (Cynara scolymus L.) during storage","volume":"90","author":"Leroy","year":"2010","journal-title":"J. Sci. Food Agric."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e1900498","DOI":"10.1002\/cbdv.201900498","article-title":"Cardoon as a Sustainable Crop for Biomass and Bioactive Compounds Production","volume":"16","author":"Barracosa","year":"2019","journal-title":"Chem. Biodivers."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1104\/pp.103.026807","article-title":"Properties of fructan:fructan 1-fructosyltransferases from chicory and globe thistle, two asteracean plants storing greatly different types of inulin","volume":"133","author":"Vergauwen","year":"2003","journal-title":"Plant. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1079\/BJN20041350","article-title":"Introducing inulin-type fructans","volume":"93","author":"Roberfroid","year":"2005","journal-title":"Br. J. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Petropoulos, S.A., Fernandes, \u00c2., Dias, M.I., Pereira, C., Calhelha, R., Gioia, F.D., Tzortzakis, N., Ivanov, M., Sokovic, M., and Barros, L. (2020). Wild and cultivated Centaurea raphanina subsp. mixta: A valuable source of bioactive compounds. Antioxidants, 9.","DOI":"10.3390\/antiox9040314"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13068-018-1262-1","article-title":"Lignin-carbohydrate complexes: Properties, applications, analyses, and methods of extraction: A review","volume":"11","author":"Tarasov","year":"2018","journal-title":"Biotechnol. Biofuels"}],"container-title":["Agronomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4395\/10\/8\/1088\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:52:07Z","timestamp":1760176327000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4395\/10\/8\/1088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,27]]},"references-count":65,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["agronomy10081088"],"URL":"https:\/\/doi.org\/10.3390\/agronomy10081088","relation":{},"ISSN":["2073-4395"],"issn-type":[{"type":"electronic","value":"2073-4395"}],"subject":[],"published":{"date-parts":[[2020,7,27]]}}}