{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:47:20Z","timestamp":1778150840457,"version":"3.51.4"},"reference-count":158,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T00:00:00Z","timestamp":1641081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This review presents and analyzes recent scientific findings on the structure, physiology, and neurotransmission mechanisms of transient receptor potential (TRP) and their function in the thermoregulation of mammals. The aim is to better understand the functionality of these receptors and their role in maintaining the temperature of animals, or those susceptible to thermal stress. The majority of peripheral receptors are TRP cation channels formed from transmembrane proteins that function as transductors through changes in the membrane potential. TRP are classified into seven families and two groups. The data gathered for this review include controversial aspects because we do not fully know the mechanisms that operate the opening and closing of the TRP gates. Deductions, however, suggest the intervention of mechanisms related to G protein-coupled receptors, dephosphorylation, and ligands. Several questions emerge from the review as well. For example, the future uses of these data for controlling thermoregulatory disorders and the invitation to researchers to conduct more extensive studies to broaden our understanding of these mechanisms and achieve substantial advances in controlling fever, hyperthermia, and hypothermia.<\/jats:p>","DOI":"10.3390\/ani12010106","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T22:51:50Z","timestamp":1641250310000},"page":"106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Transient Receptor Potential (TRP) and Thermoregulation in Animals: Structural Biology and Neurophysiological Aspects"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0084-8135","authenticated-orcid":false,"given":"Karina","family":"Lezama-Garc\u00eda","sequence":"first","affiliation":[{"name":"PhD Program in Biological and Health Sciences, [Doctorado en Ciencias Biol\u00f3gicas y de la Salud], Universidad Aut\u00f3noma Metropolitana, Mexico City 04960, Mexico"}]},{"given":"Daniel","family":"Mota-Rojas","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Animal Production, Universidad Aut\u00f3noma Metropolitana (UAM), Unidad Xochimilco, Mexico City 04960, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9430-9399","authenticated-orcid":false,"given":"Alfredo M. F.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Mediterranean Institute for Agriculture, Environment and Development (MED), Institute for Advanced Studies and Research, Universidade de \u00c9vora, P\u00f3lo da Mitra, Ap. 94, 7006-554 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-4261","authenticated-orcid":false,"given":"Julio","family":"Mart\u00ednez-Burnes","sequence":"additional","affiliation":[{"name":"Animal Health Group, Facultad de Medicina Veterinaria y Zootecnia, Universidad Aut\u00f3noma de Tamaulipas, Victoria City 87000, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-9522","authenticated-orcid":false,"given":"Marcelo","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Sciences, Veterinary Research Center (CIVETAN), Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), CONICET-CICPBA, Arroyo Seco S\/N, Tandil 7000, Argentina"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-0654","authenticated-orcid":false,"given":"Adriana","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Animal Production, Universidad Aut\u00f3noma Metropolitana (UAM), Unidad Xochimilco, Mexico City 04960, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1178-3242","authenticated-orcid":false,"given":"Jocelyn","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Animal Production, Universidad Aut\u00f3noma Metropolitana (UAM), Unidad Xochimilco, Mexico City 04960, Mexico"}]},{"given":"Ana","family":"de Mira Geraldo","sequence":"additional","affiliation":[{"name":"Mediterranean Institute for Agriculture, Environment and Development (MED), Institute for Advanced Studies and Research, Universidade de \u00c9vora, P\u00f3lo da Mitra, Ap. 94, 7006-554 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9332-6442","authenticated-orcid":false,"given":"Pamela","family":"Lendez","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Sciences, Veterinary Research Center (CIVETAN), Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), CONICET-CICPBA, Arroyo Seco S\/N, Tandil 7000, Argentina"}]},{"given":"Ismael","family":"Hern\u00e1ndez-\u00c1valos","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Cuautitl\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Cuautitlan Izcalli 54714, Mexico"}]},{"given":"Isabel","family":"Falc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Animal Production, Universidad Aut\u00f3noma Metropolitana (UAM), Unidad Xochimilco, Mexico City 04960, Mexico"}]},{"given":"Adriana","family":"Olmos-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Division of Biotechnology\u2014Bioterio and Experimental Surgery, Instituto Nacional de Rehabilitaci\u00f3n-Luis Guillermo Ibarra Ibarra (INR-LGII), Tlalpan, Mexico City 14389, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7322-2371","authenticated-orcid":false,"given":"Dehua","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Shandong University, Qingdao 266237, China"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,2]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Thermal homeostasis in the newborn puppy: Behavioral and physiological responses","volume":"9","year":"2021","journal-title":"J. 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