{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T13:15:36Z","timestamp":1774098936078,"version":"3.50.1"},"reference-count":113,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007652","name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","doi-asserted-by":"publisher","award":["RTA 2015-00021-C03"],"award-info":[{"award-number":["RTA 2015-00021-C03"]}],"id":[{"id":"10.13039\/100007652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["BES2017-080567"],"award-info":[{"award-number":["BES2017-080567"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The demand of optimal protein for human consumption is growing. The Food and Agriculture Organization (FAO) has highlighted aquaculture as one of the most promising alternatives for this protein supply gap due to the high efficiency of fish growth. However, aquaculture has been facing its own sustainability problem, because its high demand for protein has been traditionally satisfied with the use of fishmeal (FM) as the main source. Some of the most promising and sustainable protein substitutes for FM come from insects. The present manuscript provides insight into an experiment carried out on rainbow trout (Oncorhynchus mykiss) with a 50% replacement of FM with different larvae insect meals: Hermetia illucens (HI), and Tenebrio molitor (TM). TM showed better results for growth, protein utilization and more active digestive function, supported by intestinal histological changes. Liver histology and intermediary metabolism did not show relevant changes between insect meals, while other parameters such as antioxidant enzyme activities and tissue damage indicators showed the potential of insect meals as functional ingredients.<\/jats:p>","DOI":"10.3390\/ani12020179","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T23:17:07Z","timestamp":1642029427000},"page":"179","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Fishmeal Dietary Replacement Up to 50%: A Comparative Study of Two Insect Meals for Rainbow Trout (Oncorhynchus mykiss)"],"prefix":"10.3390","volume":"12","author":[{"given":"Federico","family":"Melench\u00f3n","sequence":"first","affiliation":[{"name":"Agro-Technological Institute of Castilla y Le\u00f3n, Ctra. Ar\u00e9valo s\/n, 40196 Segovia, Spain"}]},{"given":"Eduardo","family":"de Mercado","sequence":"additional","affiliation":[{"name":"Agro-Technological Institute of Castilla y Le\u00f3n, Ctra. Ar\u00e9valo s\/n, 40196 Segovia, Spain"}]},{"given":"H\u00e9ctor J.","family":"Pula","sequence":"additional","affiliation":[{"name":"Department of Zoology, Campus Fuentenueva, Facultad de Ciencias, University of Granada, 18071 Granada, Spain"}]},{"given":"Gabriel","family":"Cardenete","sequence":"additional","affiliation":[{"name":"Department of Zoology, Campus Fuentenueva, Facultad de Ciencias, University of Granada, 18071 Granada, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8828-9686","authenticated-orcid":false,"given":"Fernando G.","family":"Barroso","sequence":"additional","affiliation":[{"name":"Department of Biology and Geology, University of Almer\u00eda, 04120 Almer\u00eda, Spain"}]},{"given":"Dmitri","family":"Fabrikov","sequence":"additional","affiliation":[{"name":"Department of Biology and Geology, University of Almer\u00eda, 04120 Almer\u00eda, Spain"}]},{"given":"Helena M.","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Division of Aquaculture, Valorisation and Bioprospection, Portuguese Institute for Sea and Atmosphere (IPMA, IP), Av. Dr. Alfredo Magalh\u00e3es Ramalho 6, 1495-165 Alg\u00e9s, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9352-9776","authenticated-orcid":false,"given":"Mar\u00eda-Fernanda","family":"Pessoa","sequence":"additional","affiliation":[{"name":"GeoBioTec, Departamento de Ci\u00eancias da Terra, Faculdade de Ci\u00eancias e Tecnologia, Nova School, 2829-516 Monte da Caparica, Portugal"}]},{"given":"Leidy","family":"Lagos","sequence":"additional","affiliation":[{"name":"Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, P.O. Box 5003, NO-1432 \u00c5s, Norway"}]},{"given":"Pabodha","family":"Weththasinghe","sequence":"additional","affiliation":[{"name":"Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, P.O. Box 5003, NO-1432 \u00c5s, Norway"}]},{"given":"Marcos","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Centre of Aquatic Biotechnology, Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Av. Bernardo O\u2019Higgins 3363, Santiago 9170002, Chile"}]},{"given":"Cristina","family":"Tom\u00e1s-Almenar","sequence":"additional","affiliation":[{"name":"Agro-Technological Institute of Castilla y Le\u00f3n, Ctra. Ar\u00e9valo s\/n, 40196 Segovia, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"ref_1","unstructured":"United Nations, Department of Economic and Social Affairs, Population Division (2019). 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