{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:10:32Z","timestamp":1771305032016,"version":"3.50.1"},"reference-count":70,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MICIIN-FEDER","award":["AGL2016-77813-R"],"award-info":[{"award-number":["AGL2016-77813-R"]}]},{"name":"MICIIN-FEDER","award":["PRE2020-092905"],"award-info":[{"award-number":["PRE2020-092905"]}]},{"name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["AGL2016-77813-R"],"award-info":[{"award-number":["AGL2016-77813-R"]}]},{"name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PRE2020-092905"],"award-info":[{"award-number":["PRE2020-092905"]}]},{"name":"AEI-ESF","award":["AGL2016-77813-R"],"award-info":[{"award-number":["AGL2016-77813-R"]}]},{"name":"AEI-ESF","award":["PRE2020-092905"],"award-info":[{"award-number":["PRE2020-092905"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>A total of 106 West African taurine cattle belonging to the Lagunaire breed of Benin (33), the N\u2019Dama population of Burkina Faso (48), and N\u2019Dama cattle sampled in Congo (25) were analyzed for Copy Number Variations (CNVs) using the BovineHDBeadChip of Illumina and two different CNV calling programs: PennCNV and QuantiSNP. Furthermore, 89 West African zebu samples (Bororo cattle of Mali and Zebu Peul sampled in Benin and Burkina Faso) were used as an outgroup to ensure that analyses reflect the taurine cattle genomic background. Analyses identified 307 taurine-specific CNV regions (CNVRs), covering about 56 Mb on all bovine autosomes. Gene annotation enrichment analysis identified a total of 840 candidate genes on 168 taurine-specific CNVRs. Three different statistically significant functional term annotation clusters (from ACt1 to ACt3) involved in the immune function were identified: ACt1 includes genes encoding lipocalins, proteins involved in the modulation of immune response and allergy; ACt2 includes genes encoding coding B-box-type zinc finger proteins and butyrophilins, involved in innate immune processes; and Act3 includes genes encoding lectin receptors, involved in the inflammatory responses to pathogens and B- and T-cell differentiation. The overlap between taurine-specific CNVRs and QTL regions associated with trypanotolerant response and tick-resistance was relatively low, suggesting that the mechanisms underlying such traits may not be determined by CNV alterations. However, four taurine-specific CNVRs overlapped with QTL regions associated with both traits on BTA23, therefore suggesting that CNV alterations in major histocompatibility complex (MHC) genes can partially explain the existence of genetic mechanisms shared between trypanotolerance and tick resistance in cattle. This research contributes to the understanding of the genomic features of West African taurine cattle.<\/jats:p>","DOI":"10.3390\/ani12162130","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T21:05:51Z","timestamp":1661115951000},"page":"2130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Identification and Characterization of Copy Number Variations Regions in West African Taurine Cattle"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6872-1045","authenticated-orcid":false,"given":"F\u00e9lix","family":"Goyache","sequence":"first","affiliation":[{"name":"Servicio Regional de Investigaci\u00f3n y Desarrollo Agroalimentario, 33394 Gij\u00f3n, Spain"}]},{"given":"Luc\u00eda","family":"P\u00e9rez-Pardal","sequence":"additional","affiliation":[{"name":"CIBIO-InBIO, Universidade do Porto, 4485-661 Vair\u00e3o, Portugal"}]},{"given":"Iv\u00e1n","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Servicio Regional de Investigaci\u00f3n y Desarrollo Agroalimentario, 33394 Gij\u00f3n, Spain"}]},{"given":"Amadou","family":"Traor\u00e9","sequence":"additional","affiliation":[{"name":"Institut de l\u2019Environnement et des Recherches Agricoles (INERA), Ouagadougou 04 BP 8645, Burkina Faso"}]},{"given":"Nuria A.","family":"Men\u00e9ndez-Arias","sequence":"additional","affiliation":[{"name":"Servicio Regional de Investigaci\u00f3n y Desarrollo Agroalimentario, 33394 Gij\u00f3n, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6710-4208","authenticated-orcid":false,"given":"Katherine D.","family":"Arias","sequence":"additional","affiliation":[{"name":"Servicio Regional de Investigaci\u00f3n y Desarrollo Agroalimentario, 33394 Gij\u00f3n, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-8881","authenticated-orcid":false,"given":"Isabel","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Servicio Regional de Investigaci\u00f3n y Desarrollo Agroalimentario, 33394 Gij\u00f3n, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1023\/A:1006607228662","article-title":"Animal Disease Challenges to the Emergence of Pastoralism in Sub-Saharan Africa","volume":"17","year":"2000","journal-title":"Afr. Archaeol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1111\/mec.12816","article-title":"Adaptive Admixture in the West African Bovine Hybrid Zone: Insight from the Borgou Population","volume":"23","author":"Flori","year":"2014","journal-title":"Mol. Ecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"911","DOI":"10.5713\/ajas.15.0002R","article-title":"African Indigenous Cattle: Unique Genetic Resources in a Rapidly Changing World","volume":"28","author":"Mwai","year":"2015","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pt.2008.12.004","article-title":"Trypanotolerance in Small Ruminants of Sub-Saharan Africa","volume":"25","author":"Geerts","year":"2009","journal-title":"Trends Parasitol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s11250-012-0248-4","article-title":"Trypanosomosis: A Priority Disease in Tsetse-Challenged Areas of Burkina Faso","volume":"45","author":"Wurzinger","year":"2013","journal-title":"Trop. Anim. Health Prod."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0001-706X(00)00063-2","article-title":"Immunogenetic Influences on Tick Resistance in African Cattle with Particular Reference to Trypanotolerant N\u2019Dama (Bos Taurus) and Trypanosusceptible Gobra Zebu (Bos Indicus) Cattle","volume":"75","author":"Mattioli","year":"2000","journal-title":"Acta Trop."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Berthier, D., Peylhard, M., Dayo, G.K., Flori, G.K., Sylla, S., Bolly, S., Sakande, H., Chantal, I., and Thevenon, S. (2015). A Comparison of Phenotypic Traits Related to Trypanotolerance in Five West African Cattle Breeds Highlights the Value of Shorthorn Taurine Breeds. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126498"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Orenge, C.O., Munga, L., Kimwele, C.N., Kemp, S., Korol, A., Gibson, J.P., Hanotte, O., and Soller, M. (2012). Trypanotolerance in N\u2019Dama x Boran Crosses under Natural Trypanosome Challenge: Effect of Test-Year Environment, Gender, and Breed Composition. BMC Genet., 13.","DOI":"10.1186\/1471-2156-13-87"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2052.2011.02227.x","article-title":"Association Studies in QTL Regions Linked to Bovine Trypanotolerance in a West African Crossbred Population","volume":"43","author":"Dayo","year":"2011","journal-title":"Anim. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1073\/pnas.1232392100","article-title":"Mapping of Quantitative Trait Loci Controlling Trypanotolerance in a Cross of Tolerant West African N\u2019Dama and Susceptible East African Boran Cattle","volume":"100","author":"Hanotte","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/10495398.2015.1053606","article-title":"African Cattle Do not Carry Unique Mutations on the Exon 9 of the ARHGAP15 Gene","volume":"27","author":"Goyache","year":"2016","journal-title":"Anim. Biotechnol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/jbg.12181","article-title":"Lack of Haplotype Structuring for Two Candidate Genes for Trypanotolerance in Cattle","volume":"133","author":"Goyache","year":"2016","journal-title":"J. Anim. Breed. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.meegid.2016.04.029","article-title":"Lack of Specific Alleles for the Bovine Chemokine (C-X-C) Receptor Type 4 (CXCR4) Gene in West African Cattle Questions Its Role as a Candidate for Trypanotolerance","volume":"42","author":"Goyache","year":"2016","journal-title":"Infect. Genet. Evol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1111\/j.1365-294X.2009.04141.x","article-title":"Detection of Selection Signatures within Candidate Regions Underlying Trypanotolerance in Outbred Cattle Populations","volume":"18","author":"Dayo","year":"2009","journal-title":"Mol. Ecol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"145899","DOI":"10.1016\/j.gene.2021.145899","article-title":"Ancient Autozygous Segments Subject to Positive Selection Suggest Adaptive Immune Responses in West African Cattle","volume":"803","author":"Goyache","year":"2021","journal-title":"Gene"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9304","DOI":"10.1073\/pnas.1013486108","article-title":"Genetic and Expression Analysis of Cattle Identifies Candidate Genes in Pathways Responding to Trypanosoma Congolense Infection","volume":"108","author":"Noyes","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrg1767","article-title":"Structural Variation in the Human Genome","volume":"7","author":"Feuk","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/ng2093","article-title":"Challenges and Standards in Integrating Surveys of Structural Variation","volume":"39","author":"Scherer","year":"2007","journal-title":"Nat. Genet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nature08516","article-title":"Origins and Functional Impact of Copy Number Variation in the Human Genome","volume":"464","author":"Conrad","year":"2010","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.ygeno.2020.10.012","article-title":"Genomic Sequencing Analysis Reveals Copy Number Variations and Their Associations with Economically Important Traits in Beef Cattle","volume":"113","author":"Yang","year":"2021","journal-title":"Genomics"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Da Silva, J.M., Giachetto, P.F., da Silva, L.O., Cintra, L.C., Paiva, S.R., Yamagishi, M.E.B., and Caetano, A.R. (2016). Genome-Wide Copy Number Variation (CNV) Detection in Nelore Cattle Reveals Highly Frequent Variants in Genome Regions Harboring QTLs Affecting Production Traits. BMC Genom., 17.","DOI":"10.1186\/s12864-016-2752-9"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s11250-015-0891-7","article-title":"Geographical Assessment of Body Measurements and Qualitative Traits in West African Cattle","volume":"47","author":"Granda","year":"2015","journal-title":"Trop. Anim. Health Prod."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.5194\/aab-59-337-2016","article-title":"Multivariate Characterization of Morphological Traits in West African Cattlesires","volume":"59","author":"Diarra","year":"2016","journal-title":"Arch. Anim. Breed."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.5194\/aab-60-363-2017","article-title":"Morphological Assessment of the Zebu Bororo (Wodaab\u00e9) Cattle of Niger in the West African Zebu Framework","volume":"60","author":"Moussa","year":"2017","journal-title":"Arch. Anim. Breed."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1007\/s11033-014-3239-x","article-title":"Assessing Introgression of Sahelian Zebu Genes into Native Bos Taurus Breeds in Burkina Faso","volume":"41","author":"Cuervo","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"ref_26","unstructured":"(2022, June 21). Coordinate Remapping Service: NCBI, Available online: https:\/\/www.ncbi.nlm.nih.gov\/genome\/tools\/remap."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-Generation PLINK: Rising to the Challenge of Larger and Richer Datasets","volume":"4","author":"Chang","year":"2015","journal-title":"GigaScience"},{"key":"ref_28","unstructured":"Wickham, H. (2022, June 20). Ggplo2: Elegant Data Visualisations Using the Grammar of Graphics. Available online: https:\/\/ggplot2.tidyverse.org\/."},{"key":"ref_29","unstructured":"(2022, June 21). The Comprehensive R Archive Network. Available online: https:\/\/cran.r-project.org\/."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/jbg.12542","article-title":"Functional Characterization of Copy Number Variations Regions in Djallonk\u00e9 Sheep","volume":"138","author":"Goyache","year":"2021","journal-title":"J. Anim. Breed. Genet."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1101\/gr.6861907","article-title":"PennCNV: An Integrated Hidden Markov Model Designed for High-Resolution Copy Number Variation Detection in Whole-Genome SNP Genotyping Data","volume":"17","author":"Wang","year":"2007","journal-title":"Genome Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1093\/nar\/gkm076","article-title":"QuantiSNP: An Objective Bayes Hidden-Markov Model to Detect and Accurately Map Copy Number Variation Using SNP Genotyping Data","volume":"35","author":"Colella","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: A Flexible Suite of Utilities for Comparing Genomic Features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Hou, Y., Liu, G.E., Bickhart, D.M., Cardone, M.F., Wang, K., Kim, E., Matukumalli, L.K., Ventura, M., Song, J., and VanRaden, P.M. (2011). Genomic Characteristics of Cattle Copy Number Variations. BMC Genom., 12.","DOI":"10.1186\/1471-2164-12-127"},{"key":"ref_35","first-page":"e251","article-title":"RIdeogram: Drawing SVG Graphics to Visualize and Map Genome-Wide Data on the Idiograms","volume":"6","author":"Hao","year":"2020","journal-title":"PeerJComput. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"bar030","DOI":"10.1093\/database\/bar030","article-title":"EnsemblBioMarts: A Hub for Data Retrieval across Taxonomic Space","volume":"2011","author":"Kinsella","year":"2011","journal-title":"Database"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and Integrative Analysis of Large Gene Lists Using DAVID Bioinformatics Resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1093\/bioinformatics\/btx763","article-title":"ShinyCircos: An R\/Shiny Application for Interactive Creation of Circos Plot","volume":"34","author":"Yu","year":"2018","journal-title":"Bioinformatics"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"D604","DOI":"10.1093\/nar\/gkl946","article-title":"AnimalQTLdb: A Livestock QTL Database Tool Set for Positional QTL Information Mining and Beyond","volume":"35","author":"Hu","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_40","unstructured":"(2022, June 21). Cattle QTL Database. Available online: https:\/\/www.animalgenome.org\/cgi-bin\/QTLdb\/BT\/summary."},{"key":"ref_41","unstructured":"(2022, June 21). Draw Venn Diagram. Available online: http:\/\/bioinformatics.psb.ugent.be\/webtools\/Venn\/."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Machado, M.A., Azevedo, A.L.S., Teodoro, R.L., Pires, M.A., Peixoto, M.G., de Freitas, C., Prata, M.C., Furlong, J., da Silva, M.V., and Guimar\u00e3es, S.E. (2010). Genome Research Article Wide Scan for Quantitative Trait Loci Affecting Tick Resistance in Cattle (Bos Taurus \u00d7 Bos Indicus). BMC Genom., 11.","DOI":"10.1186\/1471-2164-11-280"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11020","DOI":"10.3168\/jds.2017-14223","article-title":"Genome-Wide Association Studies for Tick Resistance in Bos Taurus \u00d7 Bos Indicus Crossbred Cattle: A Deeper Look into This Intricate Mechanism","volume":"101","author":"Otto","year":"2018","journal-title":"J. Dairy Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ttbdis.2016.02.005","article-title":"Genome-Wide Association Study of Tick Resistance in South African Nguni Cattle","volume":"7","author":"Mapholi","year":"2016","journal-title":"Ticks Tick-Borne Dis."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"\u00c1lvarez, I., Fern\u00e1ndez, I., Traor\u00e9, A., Men\u00e9ndez-Arias, N.A., and Goyache, F. (2021). Population Structure Assessed Using Microsatellite and SNP Data: An Empirical Comparison in West African Cattle. Animals, 11.","DOI":"10.3390\/ani11010151"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1016\/j.ygeno.2021.07.005","article-title":"Introgression Contributes to Distribution of Structural Variations in Cattle","volume":"113","author":"Upadhyay","year":"2021","journal-title":"Genomics"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Hu, Y., Xia, H., Li, M., Xu, C., Ye, X., Su, R., Zhang, M., Nash, O., Sonstegard, T.S., and Yang, L. (2020). Comparative Analyses of Copy Number Variations between Bos Taurus and Bos Indicus. BMC Genom., 21.","DOI":"10.1186\/s12864-020-07097-6"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1038\/s41467-020-15848-y","article-title":"Haplotype-Resolved Genomes Provide Insights into Structural Variation and Gene Content in Angus and Brahman Cattle","volume":"11","author":"Low","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1093\/jas\/sky302","article-title":"Characterization of Copy Number Variants in a Large Multibreed Population of Beef and Dairy Cattle Using High-Density Single Nucleotide Polymorphism Genotype Data1","volume":"96","author":"Rafter","year":"2018","journal-title":"J. Anim. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1101\/gr.105403.110","article-title":"Analysis of Copy Number Variations among Diverse Cattle Breeds","volume":"20","author":"Liu","year":"2010","journal-title":"Genome Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fgene.2017.00108","article-title":"Distribution and Functionality of Copy Number Variation across European Cattle Populations","volume":"8","author":"Upadhyay","year":"2017","journal-title":"Front. Genet."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"18027","DOI":"10.1038\/s41598-018-36444-7","article-title":"Legacies of Domestication, Trade and Herder Mobility Shape Extant Male Zebu Cattle Diversity in South Asia and Africa","volume":"8","author":"Ferraz","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2052.2009.01988.x","article-title":"Y-Specific Microsatellites Reveal an African Subfamily in Taurine (Bos Taurus) Cattle: Y-Chromosome Diversity in Taurine Cattle","volume":"41","author":"Royo","year":"2010","journal-title":"Anim. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Jang, J., Terefe, E., Kim, K., Lee, Y.H., Belay, G., Tijjani, A., Han, J.-L., Hanotte, O., and Kim, H. (2021). Population Differentiated Copy Number Variation of Bos Taurus, Bos Indicus and Their African Hybrids. BMC Genom., 22.","DOI":"10.1186\/s12864-021-07808-7"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/molbev\/msy028","article-title":"The Birth and Death of Olfactory Receptor Gene Families in Mammalian Niche Adaptation","volume":"35","author":"Hughes","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/all.12797","article-title":"Structural Similarities of Human and Mammalian Lipocalins, and Their Function in Innate Immunity and Allergy","volume":"71","author":"Pacios","year":"2016","journal-title":"Allergy"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ijpara.2009.10.013","article-title":"Activation of Several Key Components of the Epidermal Differentiation Pathway in Cattle Following Infestation with the Cattle Tick, Rhipicephalus (Boophilus) Microplus","volume":"40","author":"Kongsuwan","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.tibs.2017.01.002","article-title":"TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis","volume":"42","author":"Hatakeyama","year":"2017","journal-title":"Trends Biochim. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nri2413","article-title":"TRIM Family Proteins and Their Emerging Roles in Innate Immunity","volume":"8","author":"Ozato","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"399","DOI":"10.5114\/ceji.2017.72806","article-title":"Butyrophilins: An Important New Element of Resistance","volume":"42","author":"Malinowska","year":"2017","journal-title":"Cent. Eur. J. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1002\/eji.201847536","article-title":"C-Type Lectin Receptors of the Dectin-1 Cluster: Physiological Roles and Involvement in Disease","volume":"49","author":"Tone","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12711-019-0470-x","article-title":"Unraveling Genetic Sensitivity of Beef Cattle to Environmental Variation under Tropical Conditions","volume":"51","author":"Carvalheiro","year":"2019","journal-title":"Genet. Sel. Evol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1038\/ncomms4600","article-title":"Impact of Genomic Polymorphisms on the Repertoire of Human MHC Class I-Associated Peptides","volume":"5","author":"Granados","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.pt.2016.03.007","article-title":"Genomic Regions Associated with Sheep Resistance to Gastrointestinal Nematodes","volume":"32","author":"Benavides","year":"2016","journal-title":"Trends Parasitol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Thompson-Crispi, K.A., Sargolzaei, M., Ventura, R., Abo-Ismail, M., Miglior, F., Schenkel, F., and Mallard, B.A. (2014). A Genome-Wide Association Study of Immune Response Traits in Canadian Holstein Cattle. BMC Genom., 15.","DOI":"10.1186\/1471-2164-15-559"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/aps.2013.142","article-title":"Deorphanizing the Human Transmembrane Genome: A Landscape of Uncharacterized Membrane Proteins","volume":"35","author":"Babcock","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/genetics\/155.1.391","article-title":"Quantitative Trait Loci Mapping in F2 Crosses Between Outbred Lines","volume":"155","author":"Varona","year":"2000","journal-title":"Genetics"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Gautier, M., Flori, L., Riebler, A., Jaffr\u00e9zic, F., Lalo\u00e9, D., Gut, I., Moazami-Goudarzi, K., and Foulley, J.L. (2009). A Whole Genome Bayesian Scan for Adaptive Genetic Divergence in West African Cattle. BMC Genom., 10.","DOI":"10.1186\/1471-2164-10-550"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/s41588-020-0694-2","article-title":"The Mosaic Genome of Indigenous African Cattle as a Unique Genetic Resource for African Pastoralism","volume":"52","author":"Kim","year":"2020","journal-title":"Nat. Genet."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Yougbar\u00e9, B., Soudr\u00e9, A., Ou\u00e9draogo, D., Zoma, B.L., Tapsoba, A.S.R., Sanou, M., Ou\u00e9draogo-Kon\u00e9, S., Burger, P.A., Wurzinger, M., and Khayatzadeh, N. (2021). Genome-Wide Association Study of Trypanosome Prevalence and Morphometric Traits in Purebred and Crossbred Baoul\u00e9 Cattle of Burkina Faso. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0255089"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/16\/2130\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:12:21Z","timestamp":1760141541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/16\/2130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,19]]},"references-count":70,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["ani12162130"],"URL":"https:\/\/doi.org\/10.3390\/ani12162130","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,19]]}}}