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RYC2018-025337-I"],"award-info":[{"award-number":["Ref. RYC2018-025337-I"]}]},{"name":"the Plan Estatal de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnica e Innovaci\u00f3n 2017\u20132020","award":["Ref. RTI2018-099029-A-I00"],"award-info":[{"award-number":["Ref. RTI2018-099029-A-I00"]}]},{"name":"the Plan Estatal de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnica e Innovaci\u00f3n 2017\u20132020","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"the Plan Estatal de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnica e Innovaci\u00f3n 2017\u20132020","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"the Plan Estatal de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnica e Innovaci\u00f3n 2017\u20132020","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}]},{"name":"the Plan Estatal de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnica e Innovaci\u00f3n 2017\u20132020","award":["Ref. RYC2018-025337-I"],"award-info":[{"award-number":["Ref. RYC2018-025337-I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Vitamin K (VK) is a fat-soluble vitamin necessary for fish metabolism and health. VK stability as dietary component during aquafeed storage and its potential effect on intestinal microbiome in fish have not yet been completely elucidated. The convenient storage conditions of aquafeeds when supplemented with phylloquinone (VK1), as well as its potential effects on the gut microbiota of Senegalese sole (Solea senegalensis) juveniles, have been explored. Experimental feeds were formulated to contain 0, 250 and 1250 mg kg\u22121 of VK1 and were stored at different temperatures (4, \u221220 or \u221280 \u00b0C). VK stability was superior at \u221220 \u00b0C for short-term (7 days) storage, while storing at \u221280 \u00b0C was best suited for long-term storage (up to 3 months). A comparison of bacterial communities from Senegalese sole fed diets containing 0 or 1250 mg kg\u22121 of VK1 showed that VK1 supplementation decreased the abundance of the Vibrio, Pseudoalteromonas, and Rhodobacterace families. All these microorganisms were previously associated with poor health status in aquatic organisms. These results contribute not only to a greater understanding of the physiological effects of vitamin K, particularly through fish intestinal microbiome, but also establish practical guidelines in the industry for proper aquafeed storage when supplemented with VK1.<\/jats:p>","DOI":"10.3390\/ani12233248","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T02:25:36Z","timestamp":1669256736000},"page":"3248","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fish Microbiome Modulation and Convenient Storage of Aquafeeds When Supplemented with Vitamin K1"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0273-908X","authenticated-orcid":false,"given":"Marcos","family":"Acosta","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas del Noroeste, Av. Instituto Polit\u00e9cnico Nacional 195, Col. Playa Palo de Santa Rita Sur, La Paz 23096, BCS, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4776-4564","authenticated-orcid":false,"given":"Eduardo","family":"Quiroz","sequence":"additional","affiliation":[{"name":"CONACYT-CIBNOR, Av. Instituto Polit\u00e9cnico Nacional 195, Col. Playa Palo de Santa Rita Sur, Baja California Sur, La Paz 23096, BCS, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1204-9576","authenticated-orcid":false,"given":"Dariel","family":"Tovar-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas del Noroeste, Av. Instituto Polit\u00e9cnico Nacional 195, Col. Playa Palo de Santa Rita Sur, La Paz 23096, BCS, Mexico"}]},{"given":"V\u00e2nia Palma","family":"Roberto","sequence":"additional","affiliation":[{"name":"ABC Collaborative Laboratory, Association for Integrated Aging and Rejuvenation Solutions (ABC CoLAB), 8100-735 Loul\u00e9, Portugal"},{"name":"Algarve Biomedical Center Research Institute (ABC-RI), Campus Gambelas, Bld.2, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-2624","authenticated-orcid":false,"given":"Jorge","family":"Dias","sequence":"additional","affiliation":[{"name":"SPAROS Ltd., \u00c1rea Empresarial de Marim, Lote C, 8700-221 Olh\u00e3o, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9582-1957","authenticated-orcid":false,"given":"Paulo J.","family":"Gavaia","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias do Mar (CCMAR), Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal"},{"name":"Associa\u00e7\u00e3o Oceano Verde\u2013GreenCoLab, Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal"}]},{"given":"Ignacio","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro Oceanogr\u00e1fico de Vigo, Instituto Espa\u00f1ol de Oceanograf\u00eda (IEO), CSIC, 36390 Vigo, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"ref_1","unstructured":"FAO (2022). The State of World Fisheries and Aquaculture 2022, FAO."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/raq.12091","article-title":"New developments and biological insights into the farming of Solea senegalensis reinforcing its aquaculture potential","volume":"8","author":"Morais","year":"2016","journal-title":"Rev. Aquac."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Manchado, M., Planas, J.V., Cousin, X., Rebordinos, L., and Claros, M.G. (2016). Current status in other finfish species. Genomics in Aquaculture, Elsevier.","DOI":"10.1016\/B978-0-12-801418-9.00008-1"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Varghese, T., Gopan, A., and Rejish Kumar, V. (2021). Reinventing the micronutrients beyond nutrition: Functions in immune modulation and stress mitigation of fish. Biotechnological Advances in Aquaculture Health Management, Springer.","DOI":"10.1007\/978-981-16-5195-3_22"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Y\u00fafera, M. (2018). Fat-soluble vitamins in fish: A transcriptional tissue-specific crosstalk that remains to be unveiled and characterized. Emerging Issues in Fish Larvae Research, Springer International Publishing.","DOI":"10.1007\/978-3-319-73244-2"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0044-8486(95)00044-3","article-title":"Tolerance of high dietary levels of menadione bisulfite-nicotinamide by rainbow trout","volume":"134","author":"Marchetti","year":"1995","journal-title":"Oncorhynchus Mykiss. Aquac."},{"key":"ref_7","first-page":"279","article-title":"Physiological role of vitamin K in fish\u2014Review","volume":"34","author":"Udagawa","year":"2000","journal-title":"Jpn. Agric. Res. Q."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1444-2906.2001.00205.x","article-title":"The effect of dietary vitamin K (phylloquinone and menadione) levels on the vertebral formation in mummichog Fundulus heteroclitus","volume":"67","author":"Udagawa","year":"2001","journal-title":"Fish. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1365-2095.2008.00633.x","article-title":"Dietary menadione nicotinamide bisulphite (vitamin K3) does not affect growth or bone health in first-feeding fry of atlantic salmon (Salmo salar L.)","volume":"15","author":"Fjelldal","year":"2009","journal-title":"Aquac. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0044-8486(91)90040-E","article-title":"Problems associated with the present use of menadione sodium bisulfite and vitamin a in diets for atlantic salmon","volume":"92","author":"Helland","year":"1991","journal-title":"Aquaculture"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07388551.2018.1474168","article-title":"A potential biotechnological process for the sustainable production of vitamin K1","volume":"39","author":"Tarento","year":"2019","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Beato, S., Marques, C., Laiz\u00e9, V., Gavaia, P.J., and Fern\u00e1ndez, I. (2020). New insights on vitamin K metabolism in Senegalese Sole (Solea senegalensis) based on ontogenetic and tissue-specific vitamin K epoxide reductase molecular data. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103489"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.envpol.2014.07.015","article-title":"Warfarin, a potential pollutant in aquatic environment acting through pxr signaling pathway and \u03b3-glutamyl carboxylation of vitamin K-dependent proteins","volume":"194","author":"Santos","year":"2014","journal-title":"Environ. Pollut."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s10695-015-0043-z","article-title":"Zebrafish vitamin K epoxide reductases: Expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure","volume":"41","author":"Vijayakumar","year":"2015","journal-title":"Fish Physiol. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ecoenv.2019.06.042","article-title":"warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner\u2013From Molecular Mechanisms to Environmental Concerns","volume":"181","author":"Granadeiro","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.marenvres.2017.07.021","article-title":"The xenobiotic sensor PXR in a marine flatfish species (Solea senegalensis): Gene expression patterns and its regulation under different physiological conditions","volume":"130","author":"Marques","year":"2017","journal-title":"Mar. Environ. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/clinchem\/38.9.1743","article-title":"Enzymatic sample hydrolysis and HPLC in a study of phylloquinone concentration in human milk","volume":"38","author":"Lambert","year":"1992","journal-title":"Clin. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s10126-014-9571-2","article-title":"Dietary supplementation with vitamin K affects transcriptome and proteome of Senegalese sole, improving larval performance and quality","volume":"16","author":"Richard","year":"2014","journal-title":"Mar. Biotechnol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbagen.2018.09.017","article-title":"Circulating small non-coding rnas provide new insights into vitamin K nutrition and reproductive physiology in teleost fish","volume":"1863","author":"Fernandes","year":"2019","journal-title":"Biochim. Biophys. Acta BBA\u2013Gen. Subj."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1089\/ars.2011.4043","article-title":"Mycobacterium tuberculosis vitamin K epoxide reductase homologue supports vitamin k\u2013dependent carboxylation in mammalian cells","volume":"16","author":"Tie","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"15085","DOI":"10.1074\/jbc.M110.210971","article-title":"Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin k-dependent intracellular antioxidant function","volume":"286","author":"Westhofen","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6224","DOI":"10.3390\/nu7085281","article-title":"Phylogeny of the vitamin K 2,3-epoxide reductase (VKOR) family and evolutionary relationship to the disulfide bond formation protein B (DsbB) family","volume":"7","author":"Bevans","year":"2015","journal-title":"Nutrients"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s40168-017-0380-5","article-title":"Quinones are growth factors for the human gut microbiota","volume":"5","author":"Fenn","year":"2017","journal-title":"Microbiome"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fmicb.2014.00207","article-title":"Teleost microbiomes: The state of the art in their characterization, manipulation and importance in aquaculture and fisheries","volume":"5","author":"Llewellyn","year":"2014","journal-title":"Front. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fmicb.2018.00151","article-title":"Gut microbiota: An integral moderator in health and disease","volume":"9","author":"Feng","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.aquaculture.2015.06.033","article-title":"A New view of the fish gut microbiome: Advances from next-generation sequencing","volume":"448","author":"Ghanbari","year":"2015","journal-title":"Aquaculture"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1574-695X.2007.00343.x","article-title":"A review on the interactions between gut microbiota and innate immunity of fish","volume":"52","year":"2008","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.copbio.2021.07.018","article-title":"Time to integrate biotechnological approaches into fish gut microbiome research","volume":"73","author":"Luna","year":"2022","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3389\/fmicb.2018.00873","article-title":"The gut microbiota of marine fish","volume":"9","author":"Egerton","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2019.00009","article-title":"Gut microbiota and energy homeostasis in fish","volume":"10","author":"Butt","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/s41579-019-0287-1","article-title":"Your microbiome is what you eat","volume":"17","author":"York","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.aquaculture.2017.12.022","article-title":"Effects of garlic-supplemented diet on growth performance and intestinal microbiota of rainbow trout (Oncorhynchus mykiss)","volume":"486","author":"Demirkale","year":"2018","journal-title":"Aquaculture"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.fsi.2019.05.044","article-title":"Yeast \u03b2-glucans and microalgal extracts modulate the immune response and gut microbiome in Senegalese sole (Solea senegalensis)","volume":"92","author":"Carballo","year":"2019","journal-title":"Fish Shellfish. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Parata, L., Mazumder, D., Sammut, J., and Egan, S. (2020). Diet type influences the gut microbiome and nutrient assimilation of genetically improved farmed tilapia (Oreochromis niloticus). PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0237775"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1887721","DOI":"10.1080\/19490976.2021.1887721","article-title":"Dietary vitamin k is remodeled by gut microbiota and influences community composition","volume":"13","author":"Ellis","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M.T., Baker, M., Browne, W.J., Clark, A., Cuthill, I.C., and Dirnagl, U. (2020). The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PLoS Biol., 18.","DOI":"10.1371\/journal.pbio.3000410"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3354\/ame01753","article-title":"Minor revision to V4 region SSU rRNA 806R gene primer greatly increases detection of SAR11 bacterioplankton","volume":"75","author":"Approll","year":"2015","journal-title":"Aquat. Microb. Ecol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1128\/AEM.01043-13","article-title":"Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform","volume":"79","author":"Kozich","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"D643","DOI":"10.1093\/nar\/gkt1209","article-title":"The SILVA and \u201cAll-species Living Tree Project (LTP)\u201d taxonomic frameworks","volume":"42","author":"Yilmaz","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: Improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing mothur: Open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"Schloss","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1111\/anu.13138","article-title":"A feed is still only as good as its ingredients: An update on the nutritional research strategies for the optimal evaluation of ingredients for aquaculture feeds","volume":"26","author":"Glencross","year":"2020","journal-title":"Aquac. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"115284","DOI":"10.1016\/j.anifeedsci.2022.115284","article-title":"Selection and improvement of alternative raw materials for rainbow trout (Oncorhynchus mykiss) aquafeeds through a multiparametric screening tool","volume":"288","author":"Barrios","year":"2022","journal-title":"Anim. Feed. Sci. Technol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s10811-017-1281-5","article-title":"Microalgae as a potential ingredient for partial fish meal replacement in aquafeeds: Nutrient stability under different storage conditions","volume":"30","year":"2018","journal-title":"J. Appl. Phycol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"115323","DOI":"10.1016\/j.anifeedsci.2022.115323","article-title":"Characterization of storage stability of microalgal biomass for its applications as protein feed ingredients in animal and aquafeeds","volume":"288","author":"Waghmare","year":"2022","journal-title":"Anim. Feed. Sci. Technology"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Beato, S., Toledo-Sol\u00eds, F.J., and Fern\u00e1ndez, I. (2020). Vitamin K in vertebrates\u2019 reproduction: Further puzzling pieces of evidence from teleost fish species. Biomolecules, 10.","DOI":"10.3390\/biom10091303"},{"key":"ref_47","unstructured":"Coelho, M. (2022, January 11\u201312). Vitamin stability in premixes and feeds a practical approach in ruminant diets. Proceedings of the 13th Annual Florida Ruminant Nutrition Symposium, Gainesville, FL, USA."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.anifeedsci.2010.11.001","article-title":"Effect of metal specific amino acid complexes and inorganic trace minerals on vitamin stability in premixes","volume":"163","author":"Shurson","year":"2011","journal-title":"Anim. Feed. Sci. Technol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.anifeedsci.2006.03.001","article-title":"Stability of vitamins in premixes","volume":"132","year":"2007","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Wang, H., Yang, P., Li, L., Zhang, N., and Ma, Y. (2021). Effects of sources or formulations of vitamin K3 on its stability during extrusion or pelleting in swine feed. Animals, 11.","DOI":"10.3390\/ani11030633"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Yang, P., Wang, H., Zhu, M., and Ma, Y. (2020). Evaluation of extrusion temperatures, pelleting parameters, and vitamin forms on vitamin stability in feed. Animals, 10.","DOI":"10.3390\/ani10050894"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/00015127509435056","article-title":"Stability of vitamin K3 in vitaminized mixed feeds","volume":"25","author":"Leerbeck","year":"1975","journal-title":"Acta Agric. Scand."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Orlando, P., Silvestri, S., Marcheggiani, F., Cirilli, I., and Tiano, L. (2019). Menaquinone 7 stability of formulations and its relationship with purity profile. Molecules, 24.","DOI":"10.3390\/molecules24050829"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1021\/jf00022a028","article-title":"Vitamin K1 (phylloquinone) content of edible oils: Effects of heating and light exposure","volume":"40","author":"Ferland","year":"1992","journal-title":"J. Agric. Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"C491","DOI":"10.1111\/j.1750-3841.2007.00567.x","article-title":"Determination of processing effects and of storage stability on vitamin k1 (phylloquinone) in sea buckthorn berries (Hippopha\u00eb rhamnoides L. ssp. Rhamnoides) and related products","volume":"72","author":"Gutzeit","year":"2007","journal-title":"J. Food Sci."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Wang, H., Yang, P., Li, L., Zhang, N., Ma, Y., and Xu, X. (2021). Effects of Sources and Forms of Vitamin K3 on Its Storage Stability in Vitamin Premixes or Vitamin Trace Mineral Premixes. Animals, 11.","DOI":"10.3390\/ani11041140"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Shearer, M.J. (1986). Assay of K vitamins in tissues by high-performance liquid chromatography with special reference to ultraviolet detection. Methods in Enzymology, Academic Press.","DOI":"10.1016\/S0076-6879(86)23027-X"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1093\/ajcn\/67.6.1226","article-title":"Plasma lipoproteins as carriers of phylloquinone (Vitamin K1) in humans","volume":"67","author":"Sadowski","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/jn\/nxaa336","article-title":"Vitamin D and vitamin K concentrations in human brain tissue are influenced by freezer storage time: The Memory and Aging Project","volume":"151","author":"Fu","year":"2021","journal-title":"J. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/fsh.10379","article-title":"Fish gut microbiome: A primer to an emerging discipline in the fisheries sciences","volume":"45","author":"Gallo","year":"2020","journal-title":"Fisheries"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Rimoldi, S., Terova, G., Ascione, C., Giannico, R., and Brambilla, F. (2018). Next Generation Sequencing for Gut Microbiome Characterization in rainbow trout (Oncorhynchus mykiss) fed animal by-product meals as an alternative to fishmeal protein sources. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193652"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Dom\u00ednguez-Maqueda, M., Cerezo, I.M., Tapia-Paniagua, S.T., De La Banda, I.G., Moreno-Ventas, X., Mori\u00f1igo, M.\u00c1., and Balebona, M.C. (2021). A tentative study of the effects of heat-inactivation of the probiotic strain Shewanella Putrefaciens Ppd11 on Senegalese Sole (Solea senegalensis) intestinal microbiota and immune response. Microorganisms, 9.","DOI":"10.3390\/microorganisms9040808"},{"key":"ref_63","first-page":"1","article-title":"Modulation of intestinal microbiota in Solea senegalensis fed low dietary level of Ulva ohnoi","volume":"10","author":"Fumanal","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"801744","DOI":"10.3389\/fmicb.2021.801744","article-title":"Solea senegalensis bacterial intestinal microbiota is affected by low dietary inclusion of Ulva ohnoi","volume":"12","author":"Cerezo","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"736592","DOI":"10.1016\/j.aquaculture.2021.736592","article-title":"Microbial community dynamics in a hatchery recirculating aquaculture system (RAS) of sole (Solea senegalensis)","volume":"539","author":"Almeida","year":"2021","journal-title":"Aquaculture"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.fsi.2016.09.010","article-title":"Effects on intestinal microbiota and immune genes of Solea senegalensis after suspension of the administration of Shewanella Putrefaciens Pdp11","volume":"58","author":"Vidal","year":"2016","journal-title":"Fish Shellfish. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1007\/s00253-016-7592-7","article-title":"Innate immune response, intestinal morphology and microbiota changes in Senegalese sole fed plant protein diets with probiotics or autolysed yeast","volume":"100","author":"Batista","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/s10126-014-9588-6","article-title":"Probiotic Supplementation influences the diversity of the intestinal microbiota during early stages of farmed senegalese sole (Solea senegalensis, Kaup 1858)","volume":"16","author":"Lobo","year":"2014","journal-title":"Mar. Biotechnol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s00248-010-9680-z","article-title":"Intestinal microbiota diversity of the flat fish Solea senegalensis (Kaup, 1858) following probiotic administration","volume":"60","author":"Banda","year":"2010","journal-title":"Microb Ecol"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.fsi.2014.08.019","article-title":"The treatment with the probiotic Shewanella putrefaciens Pdp11 of specimens of Solea senegalensis exposed to high stocking densities to enhance their resistance to disease","volume":"41","author":"Vidal","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1111\/j.1365-2109.2007.01790.x","article-title":"Intestinal microbiota variation in Senegalese sole (Solea senegalensis) under different feeding regimes","volume":"38","author":"Manchado","year":"2007","journal-title":"Aquac. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2095.2008.00581.x","article-title":"Effect of dietary administration of probiotics on growth and intestine functionality of juvenile Senegalese sole (Solea senegalensis, Kaup 1858)","volume":"15","author":"Smidt","year":"2009","journal-title":"Aquac. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1002\/pmic.200700437","article-title":"Proteomic investigation of amino acid catabolism in the indigenous gut anaerobe Fusobacterium varium","volume":"8","author":"Potrykus","year":"2008","journal-title":"Proteomics"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fnut.2018.00090","article-title":"How can we define \u201coptimal microbiota?\u201d: A comparative review of structure and functions of microbiota of animals, fish, and plants in agriculture","volume":"5","author":"Brugman","year":"2018","journal-title":"Front. Nutr."},{"key":"ref_75","first-page":"99","article-title":"Enterobacteriaceae associated with farm fish and retailed ones","volume":"42","author":"Elsherief","year":"2014","journal-title":"Alex. J. Vet. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/jam.14302","article-title":"Variations of the intestinal gut microbiota of farmed rainbow trout, Oncorhynchus mykiss (Walbaum), depending on the infection status of the fish","volume":"127","author":"Parshukov","year":"2019","journal-title":"J. Appl. Microbiol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Wagatsuma, K., Yamada, S., Ao, M., Matsuura, M., Tsuji, H., Iida, T., Miyamoto, K., Oka, K., Takahashi, M., and Tanaka, K. (2019). Diversity of Gut Microbiota Affecting Serum Level of Undercarboxylated Osteocalcin in Patients with Crohn\u2019s Disease. Nutrients, 11.","DOI":"10.3390\/nu11071541"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1111\/cmi.12308","article-title":"Defining dysbiosis and its influence on host immunity and disease","volume":"16","author":"Petersen","year":"2014","journal-title":"Cell. Microbiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nrmicro2989","article-title":"\u201cBlooming\u201d in the gut: How dysbiosis might contribute to pathogen evolution","volume":"11","author":"Stecher","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1073\/pnas.052694299","article-title":"Quorum-sensing regulators control virulence gene expression in Vibrio cholerae","volume":"99","author":"Zhu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"13604","DOI":"10.1038\/s41598-019-49501-6","article-title":"Understanding pseudo-albinism in sole (Solea senegalensis): A transcriptomics and metagenomics approach","volume":"9","author":"Pinto","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.aquaculture.2007.06.015","article-title":"Occurrence and virulence of Pseudoalteromonas spp. in cultured gilthead sea bream (Sparus aurata L.) and European sea bass (Dicentrarchus labrax L.). Molecular and phenotypic characterisation of P. undina strain U58","volume":"271","author":"Pujalte","year":"2007","journal-title":"Aquaculture"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fphys.2015.00133","article-title":"Impact of a novel protein meal on the gastrointestinal microbiota and the host transcriptome of larval zebrafish Danio rerio","volume":"6","author":"Rurangwa","year":"2015","journal-title":"Front. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/1462-2920.13701","article-title":"Integrating gut microbiota immaturity and disease-discriminatory taxa to diagnose the initiation and severity of shrimp disease","volume":"19","author":"Xiong","year":"2017","journal-title":"Env. Microbiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41598-018-37042-3","article-title":"Dynamics of the gut microbiota in developmental stages of Litopenaeus Vannamei reveal its association with body weight","volume":"9","author":"Fan","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.aquaculture.2019.01.026","article-title":"Strain-specific changes in the gut microbiota profiles of the white shrimp Litopenaeus Vannamei in response to cold stress","volume":"503","author":"Liu","year":"2019","journal-title":"Aquaculture"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Richards, G.P., Watson, M.A., Needleman, D.S., Uknalis, J., Boyd, E.F., and Fay, J.P. (2017). Mechanisms for Pseudoalteromonas piscicida-induced killing of Vibrios and other bacterial pathogens. Appl. Environ. Microbiol., 83.","DOI":"10.1128\/AEM.00175-17"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10126-015-9627-y","article-title":"The pathogen of the great barrier reef sponge Rhopaloeides odorabile is a new strain of Pseudoalteromonas agarivorans containing abundant and diverse virulence-related genes","volume":"17","author":"Choudhury","year":"2015","journal-title":"Mar. Biotechnol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.aquaculture.2008.02.007","article-title":"Monitoring the opportunistic bacteria Pseudoalteromonas sp. LT-13 in a great scallop, Pecten maximus hatchery","volume":"276","author":"Sandaa","year":"2008","journal-title":"Aquaculture"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Rosenberg, E., DeLong, E.F., Lory, S., Stackebrandt, E., and Thompson, F. (2014). The family campylobacteraceae. The prokaryotes, Springer.","DOI":"10.1007\/978-3-642-30138-4"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/femsec\/fiaa163","article-title":"Bacterial community assembly in atlantic cod larvae (Gadus Morhua): Contributions of ecological processes and metacommunity structure","volume":"96","author":"Vestrum","year":"2020","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.3389\/fmicb.2017.02664","article-title":"The inner workings of the outer surface: Skin and gill microbiota as indicators of changing gut health in yellowtail kingfish","volume":"8","author":"Legrand","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"734202","DOI":"10.1016\/j.aquaculture.2019.734202","article-title":"Bacterial signatures of productivity decay in Penaeus monodon ponds infected with PirA toxin","volume":"511","author":"Huerlimann","year":"2019","journal-title":"Aquaculture"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1462-2920.2006.01161.x","article-title":"The bacterial storage compound poly- \u03b2-hydroxybutyrate protects Artemia franciscana from pathogenic Vibrio campbellii","volume":"9","author":"Defoirdt","year":"2007","journal-title":"Environ. Microbiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1574-6941.2007.00305.x","article-title":"Poly-\u03b2-hydroxybutyrate-accumulating bacteria protect gnotobiotic Artemia franciscana from pathogenic Vibrio campbellii: Phb-accumulating bacteria protect Artemia from Vibrio","volume":"60","author":"Halet","year":"2007","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1099\/ijs.0.63938-0","article-title":"Roseomonas lacus Sp. Nov., Isolated from freshwater lake sediment","volume":"56","author":"Jiang","year":"2006","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"31130","DOI":"10.1007\/s11356-020-09277-z","article-title":"Effect of oxygen limitation on the enrichment of bacteria degrading either benzene or toluene and the identification of Malikia spinosa (Comamonadaceae) as prominent aerobic benzene-, toluene-, and ethylbenzene-degrading bacterium: Enrichment, isolation and whole-genome analysis","volume":"27","author":"Farkas","year":"2020","journal-title":"Environ. Sci. Pollut. Res."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/23\/3248\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:24:57Z","timestamp":1760145897000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/23\/3248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,23]]},"references-count":97,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["ani12233248"],"URL":"https:\/\/doi.org\/10.3390\/ani12233248","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,23]]}}}