{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:55:47Z","timestamp":1773827747513,"version":"3.50.1"},"reference-count":51,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Regional Ministry of Economy and Infrastructure, Extremadura Government (Spain)","award":["GR21085"],"award-info":[{"award-number":["GR21085"]}]},{"name":"Regional Ministry of Economy and Infrastructure, Extremadura Government (Spain)","award":["RYC-2017-21545"],"award-info":[{"award-number":["RYC-2017-21545"]}]},{"name":"\u201cAyudas a grupos de la Universidad de Extremadura\u201d","award":["GR21085"],"award-info":[{"award-number":["GR21085"]}]},{"name":"\u201cAyudas a grupos de la Universidad de Extremadura\u201d","award":["RYC-2017-21545"],"award-info":[{"award-number":["RYC-2017-21545"]}]},{"name":"Ministry of Economy, Industry and Competitiveness (Spain)","award":["GR21085"],"award-info":[{"award-number":["GR21085"]}]},{"name":"Ministry of Economy, Industry and Competitiveness (Spain)","award":["RYC-2017-21545"],"award-info":[{"award-number":["RYC-2017-21545"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Systemic inflammatory response syndrome (SIRS) is a very common finding in critically ill patients. To accurately identify patients with SIRS and those who need intensive care, several markers have been evaluated, including cortisol, WBC or lactate. It is widely known that a stress leukogram includes eosinopenia as one of its main markers (neutrophilia, eosinopenia, lymphopenia and mild monocytes). It is known that cortisol concentration in plasma is the main stress biomarker and is strongly correlated with the severity of disease in horses. However, it is not possible to measure this parameter routinely in clinical conditions. Hence, in this study it was hypothesized that the eosinophil count could be a reliable parameter to identify critically ill horses. Horses included in this study were divided into three groups: Group A (sick horses received at the Emergency Unit which did not fulfil the criteria for SIRS), Group B (horses that meet two or more criteria for inclusion in the definition of SIRS) and a control group of healthy horses. In this study, horses with SIRS showed lower eosinophil counts than healthy horses. Moreover, non-surviving horses exhibited lower eosinophil counts than survivors. Eosinopenia could be used to identify horses with SIRS and can be useful as a prognostic marker.<\/jats:p>","DOI":"10.3390\/ani12243547","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T02:16:41Z","timestamp":1671157001000},"page":"3547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Eosinopenia as a SIRS Biomarker in Critically Ill Horses"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4169-5318","authenticated-orcid":false,"given":"Mar\u00eda","family":"Mart\u00edn-Cuervo","sequence":"first","affiliation":[{"name":"Grupo MECIAN, Departamento de Medicina Animal, Facultad de Veterinaria, Campus de C\u00e1ceres, Universidad de Extremadura, 10003 C\u00e1ceres, Spain"}]},{"given":"Luis Alfonso","family":"Gracia-Calvo","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, University of Helsinki, Koetilankuja 1, 00790 Helsinki, Finland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-9793","authenticated-orcid":false,"given":"Beatriz","family":"Mac\u00edas-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Grupo MINVET, Departamento de Medicina Animal, Facultad de Veterinaria, Campus de C\u00e1ceres, Universidad de Extremadura, 10003 C\u00e1ceres, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-9480","authenticated-orcid":false,"given":"Luis Javier","family":"Ezquerra","sequence":"additional","affiliation":[{"name":"Grupo MECIAN, Departamento de Medicina Animal, Facultad de Veterinaria, Campus de C\u00e1ceres, Universidad de Extremadura, 10003 C\u00e1ceres, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3341-7331","authenticated-orcid":false,"given":"Rafael","family":"Barrera","sequence":"additional","affiliation":[{"name":"Grupo MINVET, Departamento de Medicina Animal, Facultad de Veterinaria, Campus de C\u00e1ceres, Universidad de Extremadura, 10003 C\u00e1ceres, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Brink, A., Alsma, J., Verdonschot, R.J.C.G., Rood, P.P.M., Zietse, R., Lingsma, H.F., and Schuit, S.C.E. 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