{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T11:03:07Z","timestamp":1773572587088,"version":"3.50.1"},"reference-count":67,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (Portugal)","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (Portugal)","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (Portugal)","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (Portugal)","award":["DL57\/2016\/CP1361\/CT0033"],"award-info":[{"award-number":["DL57\/2016\/CP1361\/CT0033"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (Portugal)","award":["MAR-02.01.01-FEAMP-0175"],"award-info":[{"award-number":["MAR-02.01.01-FEAMP-0175"]}]},{"name":"DIVERSIAQUA II","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"DIVERSIAQUA II","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"DIVERSIAQUA II","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}]},{"name":"DIVERSIAQUA II","award":["DL57\/2016\/CP1361\/CT0033"],"award-info":[{"award-number":["DL57\/2016\/CP1361\/CT0033"]}]},{"name":"DIVERSIAQUA II","award":["MAR-02.01.01-FEAMP-0175"],"award-info":[{"award-number":["MAR-02.01.01-FEAMP-0175"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Taurine is a sulphur-containing amino acid with important physiological roles and a key compound for the synthesis of bile salts, which are essential for the emulsion and absorption of dietary lipids. This study aimed to evaluate the effects of taurine supplementation to low-fishmeal diets on the metabolism of taurine, bile acids, and lipids of Senegalese sole. A fishmeal (FM) and a plant-protein-based (PP0) diet were formulated, and the latter was supplemented with taurine at 0.5 and 1.5% (diets PP0.5 and PP1.5). Diets were assigned to triplicate tanks containing 35 fish (initial weight ~14 g) for 6 weeks. Fish from the PP0 treatment presented lower taurine and bile-acid concentrations compared with the FM treatment, and a downregulation of cyp7a1 and abcb11 was observed. Triolein catabolism decreased in PP0-fed fish, resulting in increased hepatic fat content and plasma triglycerides, while no effects on plasma cholesterol were observed. Taurine supplementation to plant-based diets resulted in a higher taurine accumulation in fish tissues, increased bile-acid concentration, and upregulation of cyp7a1 and abcb11. Hepatic fat content and plasma triglycerides decreased with increasing dietary taurine supplementation. Taurine supplementation mitigated part of the negative effects of plant-based diets, leading to better lipid utilisation.<\/jats:p>","DOI":"10.3390\/ani13091501","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T05:46:06Z","timestamp":1682660766000},"page":"1501","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Taurine Supplementation to Plant-Based Diets Improves Lipid Metabolism in Senegalese Sole"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9217-0183","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"Arag\u00e3o","sequence":"first","affiliation":[{"name":"Centre of Marine Sciences (CCMAR), 8005-139 Faro, Portugal"},{"name":"Universidade do Algarve, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8648-1241","authenticated-orcid":false,"given":"Rita","family":"Teod\u00f3sio","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences (CCMAR), 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7104-1844","authenticated-orcid":false,"given":"Rita","family":"Colen","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences (CCMAR), 8005-139 Faro, Portugal"}]},{"given":"Nad\u00e8ge","family":"Richard","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences (CCMAR), 8005-139 Faro, Portugal"},{"name":"Phileo by Lesaffre, 59700 Marcq-en-Baroeul, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8789-0197","authenticated-orcid":false,"given":"Ivar","family":"R\u00f8nnestad","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Bergen, 5020 Bergen, Norway"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-2624","authenticated-orcid":false,"given":"Jorge","family":"Dias","sequence":"additional","affiliation":[{"name":"SPAROS Lda., 8700-221 Olh\u00e3o, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-2068","authenticated-orcid":false,"given":"Lu\u00eds E. C.","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"SPAROS Lda., 8700-221 Olh\u00e3o, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0110-8860","authenticated-orcid":false,"given":"Laura","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"IPMA\u2014Portuguese Institute for the Ocean and Atmosphere\/EPPO\u2014Aquaculture Research Station, 8700-194 Olh\u00e3o, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41586-021-03308-6","article-title":"A 20-year retrospective review of global aquaculture","volume":"591","author":"Naylor","year":"2021","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.aquaculture.2014.12.006","article-title":"Taurine: A critical nutrient for future fish feeds","volume":"437","author":"Salze","year":"2015","journal-title":"Aquaculture"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/raq.12042","article-title":"Is dietary taurine supplementation beneficial for farmed fish and shrimp? 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