{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:18:54Z","timestamp":1776644334806,"version":"3.51.2"},"reference-count":58,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Osteoarthritis (OA) is highly prevalent in the canine population. Due to the multiple dimensions of the disease, a multimodal approach is usually favored by clinicians. To evaluate the combined treatment with intra-articular platelet-rich plasma (PRP) and photobiomodulation in dogs with bilateral hip OA, thirty dogs were assigned to a PRP group (PRPG, n = 10), a photobiomodulation group (PBMTG, n = 10), or a combined therapies group (PRP+PBMTG, n = 10). The PRPG received two intra-articular administrations of platelet-rich plasma 14 days apart. The PBMTG received photobiomodulation with a therapeutic laser, with three sessions every other day in week one; two sessions in week two; a single session in week three; and one session\/month on follow-up evaluation days. The PRP+PBMTG received the two combined therapies. The response to treatment was evaluated with weight-bearing distribution and the Canine Brief Pain Inventory, the Liverpool Osteoarthritis in Dogs, and the Canine Orthopedic Index. Evaluations were conducted before treatment and +8, +15, +30, +60, and +90 days after initial treatment. Normality was assessed with a Shapiro\u2013Wilk test, and the groups\u2019 results in each evaluation moment were compared using a Mann\u2013Whitney U test. Animals of both sexes (male n = 19, female n = 11) were included in the sample, with a mean age of 7.8 \u00b1 2.5 years and a body weight of 26.5 \u00b1 4.7 kg. Joints were classified as mild (n = 6, three in PRPG, two in PBMTG, and one in PRP+PBMTG), moderate (n = 18, six in PRPG, five in PBMTG, and seven in PRP+PBMTG), and severe (n = 6, one in PRPG, three in PBMTG, and two in PRP+PBMTG). No differences were found between groups at the initial evaluation. All treatments produced clinically significant improvements compared to the assessment on treatment day. The combination of PRP and photobiomodulation produced greater, longer-lasting improvements. PRP and photobiomodulation can improve objective outcomes and client-reported outcome measures in dogs with OA. Their combined use leads to greater, longer-lasting, clinically significant improvements.<\/jats:p>","DOI":"10.3390\/ani13203247","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T09:56:57Z","timestamp":1697623017000},"page":"3247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Preliminary Report on the Combined Effect of Intra-Articular Platelet-Rich Plasma Injections and Photobiomodulation in Canine Osteoarthritis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-3709","authenticated-orcid":false,"given":"J. C.","family":"Alves","sequence":"first","affiliation":[{"name":"Divis\u00e3o de Medicina Veterin\u00e1ria, Guarda Nacional Republicana (GNR), Rua Presidente Arriaga, 9, 1200-771 Lisbon, Portugal"},{"name":"Faculty of Veterinary Medicine, Lus\u00f3fona University, 1749-024 Lisbon, Portugal"},{"name":"Centro de Ci\u00eancia Animal e Veterin\u00e1ria, Lus\u00f3fona University, 1749-024 Lisbon, Portugal"},{"name":"MED\u2014Mediterranean Institute for Agriculture, Environment and Development, Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada, Universidade de \u00c9vora, P\u00f3lo da Mitra, Ap. 94, 7006-554 \u00c9vora, Portugal"}]},{"given":"Ana","family":"Santos","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Medicina Veterin\u00e1ria, Guarda Nacional Republicana (GNR), Rua Presidente Arriaga, 9, 1200-771 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6784-2806","authenticated-orcid":false,"given":"L. Miguel","family":"Carreira","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Lisbon (FMV\/ULisboa), 1300-477 Lisbon, Portugal"},{"name":"Interdisciplinary Centre for Research in Animal Health (CIISA), University of Lisbon (FMV\/ULisboa), 1649-004 Lisbon, Portugal"},{"name":"Anjos of Assis Veterinary Medicine Centre (CMVAA), 2830-077 Barreiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Alves, J.C., Santos, A., Jorge, P., Lavrador, C., and Carreira, L.M. (2020). Clinical and diagnostic imaging findings in police working dogs referred for hip osteoarthritis. BMC Vet. 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