{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:14:58Z","timestamp":1770833698965,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>In this retrospective study to determine the optimal method of evaluating static weight-bearing distribution to assess response to treatment in dogs with osteoarthritis using a weight distribution platform, data from the Clinica Veterin\u00e1ria de C\u00e3es (Portuguese Republican National Guard) clinical records were extracted. At baseline and at 15 days post-treatment, follow-up data from 80 dogs treated for bilateral hip osteoarthritis were categorized based on an anchor question. Estimates of minimal clinically important differences were calculated with distribution-based and anchor-based methods for deviation from normal weight-bearing and a symmetry index (SI). For deviation, the anchor-based methods provided a range from \u22120.3 to \u22123.1, and the distribution-based methods from 0.16 to 0.29. For SI, the anchor-based methods provided a range from \u221210.0 to \u221223.9, and the distribution-based methods from 1.31 to 2.88. Receiver operator characteristic curves provided areas under the curve &gt;0.7, indicating an acceptable cut-off point. We presented estimates of \u22121 for deviation and \u221210 for SI in dogs with OA. These estimates can be used for research and patient monitoring. Future studies should include OA from other joints and animals from a broader clinical context.<\/jats:p>","DOI":"10.3390\/ani14010128","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T09:15:11Z","timestamp":1703841311000},"page":"128","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Minimal Clinically Important Differences for a Weight Distribution Platform in Dogs with Osteoarthritis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-3709","authenticated-orcid":false,"given":"J. C.","family":"Alves","sequence":"first","affiliation":[{"name":"Divis\u00e3o de Medicina Veterin\u00e1ria, Guarda Nacional Republicana (GNR), Rua Presidente Arriaga, 9, 1200-771 Lisbon, Portugal"},{"name":"Faculty of Veterinary Medicine, Lus\u00f3fona University, 1749-024 Lisbon, Portugal"},{"name":"Centro de Ci\u00eancia Animal e Veterin\u00e1ria, Lus\u00f3fona University, 1749-024 Lisbon, Portugal"},{"name":"MED\u2014Mediterranean Institute for Agriculture, Environment and Development, Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada, Universidade de \u00c9vora, P\u00f3lo da Mitra, Ap. 94, 7006-554 \u00c9vora, Portugal"}]},{"given":"Ana","family":"Santos","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Medicina Veterin\u00e1ria, Guarda Nacional Republicana (GNR), Rua Presidente Arriaga, 9, 1200-771 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2927-9071","authenticated-orcid":false,"given":"Catarina","family":"Lavrador","sequence":"additional","affiliation":[{"name":"MED\u2014Mediterranean Institute for Agriculture, Environment and Development, Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada, Universidade de \u00c9vora, P\u00f3lo da Mitra, Ap. 94, 7006-554 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6784-2806","authenticated-orcid":false,"given":"L. Miguel","family":"Carreira","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Lisbon (FMV\/ULisboa), 1300-477 Lisbon, Portugal"},{"name":"Interdisciplinary Centre for Research in Animal Health (CIISA), University of Lisbon, (FMV\/ULisboa), 1649-004 Lisbon, Portugal"},{"name":"Anjos of Assis Veterinary Medicine Centre (CMVAA), 2830-077 Barreiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zink, C., and Van Dyke, J. (2018). Canine Sports Medicine and Rehabilitation, John Wiley & Sons, Ltd.. [2nd ed.].","DOI":"10.1002\/9781119380627"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1038\/s41598-018-23940-z","article-title":"Prevalence, duration and risk factors for appendicular osteoarthritis in a UK dog population under primary veterinary care","volume":"8","author":"Anderson","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_3","unstructured":"Enomoto, M., Castro, N., Hash, J., Nakanishi, A., Taylor, A., Snyder, A., Ross-Estrada, M., Ferris, K., Deresienski, D., and Frey, E. (2022). NC State College of Veterinary Medicine Research Forum, NC State CVM."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Alves, J.C., Santos, A., Jorge, P., Lavrador, C., and Carreira, L.M. (2021). Comparison of clinical and radiographic signs of hip osteoarthritis in contralateral hip joints of fifty working dogs. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0248767"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1055\/s-0038-1667063","article-title":"Sensitivity and specificity of a weight distribution platform for the detection of objective lameness and orthopaedic disease","volume":"31","author":"Clough","year":"2018","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Meijer, E., Bertholle, C.P., Oosterlinck, M., van der Staay, F.J., Back, W., and van Nes, A. (2014). Pressure mat analysis of the longitudinal development of pig locomotion in growing pigs after weaning. BMC Vet. Res., 10.","DOI":"10.1186\/s12917-014-0193-8"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/vsu.12512","article-title":"Evaluation of a single intra-articular injection of autologous protein solution for treatment of osteoarthritis in a canine population","volume":"45","author":"Wanstrath","year":"2016","journal-title":"Vet. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2460\/ajvr.67.2.277","article-title":"Evaluation of a pressure walkway system for measurement of vertical limb forces in clinically normal dogs","volume":"67","author":"Lascelles","year":"2006","journal-title":"Am. J. Vet. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3415\/VCOT-11-09-0135","article-title":"Use of bathroom scales in measuring asymmetry of hindlimb static weight bearing in dogs with osteoarthritis","volume":"25","author":"Junnila","year":"2012","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1532-950X.2012.00957.x","article-title":"Comparison of Body Weight Distribution, Peak Vertical Force, and Vertical Impulse as Measures of Hip Joint Pain and Efficacy of Total Hip Replacement","volume":"41","author":"Seibert","year":"2012","journal-title":"Vet. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1055\/s-0038-1668246","article-title":"Assessing clinical relevance of weight distribution as measured on a stance analyzer through comparison with lameness determined on a pressure sensitive walkway and clinical diagnosis","volume":"31","author":"Clough","year":"2018","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3415\/VCOT-16-09-0128","article-title":"Repeatability and accuracy testing of a weight distribution platform and comparison to a pressure sensitive walkway to assess static weight distribution","volume":"30","author":"Bosscher","year":"2017","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2460\/ajvr.80.4.403","article-title":"Single-day and multiday repeatability of stance analysis results for dogs with hind limb lameness","volume":"80","author":"Wilson","year":"2019","journal-title":"Am. J. Vet. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100655","DOI":"10.1016\/j.tcam.2022.100655","article-title":"Characterization of Weight-bearing Compensation in Dogs with Bilateral Hip Osteoarthritis","volume":"49","author":"Alves","year":"2022","journal-title":"Top. Companion Anim. Med."},{"key":"ref_15","first-page":"108","article-title":"The effect of measurement method on static weight distribution to all legs in dogs using the Quadruped Biofeedback System","volume":"20","author":"Phelps","year":"2007","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3415\/VCOT-16-05-0075","article-title":"The effect of limb amputation on standing weight distribution in the remaining three limbs in dogs","volume":"30","author":"Cole","year":"2017","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"White, D.A., Harkin, K.R., Roush, J.K., Renberg, W.C., and Biller, D. (2020). Fortetropin inhibits disuse muscle atrophy in dogs after tibial plateau leveling osteotomy. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0231306"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ben-Amotz, R., Dycus, D., Levine, D., Arruda, A.G., Fagan, N., and Marcellin-Little, D. (2020). Stance and weight distribution after tibial plateau leveling osteotomy in forelimb and hind limb amputee dogs. BMC Vet. Res., 16.","DOI":"10.1186\/s12917-020-02402-7"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.2460\/ajvr.74.12.1467","article-title":"Power of treatment success definitions when the Canine Brief Pain Inventory is used to evaluate carprofen treatment for the control of pain and inflammation in dogs with osteoarthritis","volume":"74","author":"Brown","year":"2013","journal-title":"Am. J. Vet. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"iii40","DOI":"10.1136\/ard.2007.079798","article-title":"Minimal clinically important improvement\/difference (MCII\/MCID) and patient acceptable symptom state (PASS): What do these concepts mean?","volume":"66","author":"Kvien","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"ref_21","first-page":"1","article-title":"Initial psychometric evaluation of the Portuguese version of the Canine Brief Pain Inventory","volume":"84","author":"Alves","year":"2022","journal-title":"Am. J. Vet. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1177\/0194599819852604","article-title":"Understanding the Minimal Clinically Important Difference (MCID) of Patient-Reported Outcome Measures","volume":"161","author":"Sedaghat","year":"2019","journal-title":"Otolaryngol.\u2013Head Neck Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1532-950X.2009.00607.x","article-title":"Evaluation of functional outcome after BFX total hip replacement using a pressure sensitive walkway","volume":"39","author":"Lascelles","year":"2010","journal-title":"Vet. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Alves, J.C., Santos, A., Jorge, P., Lavrador, C., and Carreira, L.M. (2020). A report on the use of a single intra-articular administration of autologous platelet therapy in a naturally occurring canine osteoarthritis model\u2014A preliminary study. BMC Musculoskelet. Disord., 21.","DOI":"10.1186\/s12891-020-3140-9"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1038\/s41598-021-82795-z","article-title":"Intraarticular triamcinolone hexacetonide, stanozolol, Hylan G-F 20 and platelet concentrate in a naturally occurring canine osteoarthritis model","volume":"11","author":"Alves","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Alves, J.C., Santos, A., and Jorge, P. (2021). Platelet-rich plasma therapy in dogs with bilateral hip osteoarthritis. BMC Vet. Res., 17.","DOI":"10.1186\/s12917-021-02913-x"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Alves, J.C., and Innes, J.F. (2023). Minimal clinically-important differences for the \u201cLiverpool Osteoarthritis in Dogs\u201d (LOAD) and the \u201cCanine Orthopedic Index\u201d (COI) in dogs with osteoarthritis. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0291881"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Innes, J.F., Morton, M.A., and Lascelles, B.D.X. (2023). Minimal clinically-important differences for the \u2018Liverpool Osteoarthritis in Dogs\u2019 (LOAD) and the \u2018Canine Orthopedic Index\u2019 (COI) client-reported outcomes measures. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0280912"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.2460\/javma.233.8.1278","article-title":"Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis","volume":"233","author":"Brown","year":"2008","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Walton, M.B., Cowderoy, E., Lascelles, D., and Innes, J.F. (2013). Evaluation of construct and criterion validity for the \u2018Liverpool Osteoarthritis in Dogs\u2019 (LOAD) clinical metrology instrument and comparison to two other instruments. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058125"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3415\/VCOT-16-04-0054","article-title":"The evaluation of limb symmetry indices using ground reaction forces collected with one or two force plates in healthy dogs","volume":"30","author":"Volstad","year":"2017","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"512523","DOI":"10.3389\/fvets.2020.512523","article-title":"A Pilot Study on the Efficacy of a Single Intra-Articular Administration of Triamcinolone Acetonide, Hyaluronan, and a Combination of Both for Clinical Management of Osteoarthritis in Police Working Dogs","volume":"7","author":"Alves","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Alves, J.C., Santos, A., Jorge, P., and Carreira, L.M. (2022). A randomized double-blinded controlled trial on the effects of photobiomodulation therapy in dogs with osteoarthritis. Am. J. Vet. Res., 83.","DOI":"10.2460\/ajvr.22.03.0036"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1586\/14737167.2014.894462","article-title":"The minimum clinically important difference for EQ-5D index: A critical review","volume":"14","author":"Coretti","year":"2014","journal-title":"Expert Rev. Pharmacoecon. Outcomes Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jclinepi.2007.03.012","article-title":"Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes","volume":"61","author":"Revicki","year":"2008","journal-title":"J. Clin. Epidemiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1177\/1947603518799839","article-title":"Minimal Clinically Important Differences and Substantial Clinical Benefit in Patient-Reported Outcome Measures after Autologous Chondrocyte Implantation","volume":"11","author":"Ogura","year":"2018","journal-title":"CARTILAGE"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1055\/s-0038-1677509","article-title":"Kinetic and Kinematic Analysis of Dogs Suffering from Hip Osteoarthritis and Healthy Dogs Across Different Physical Activities","volume":"32","author":"Souza","year":"2019","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1160\/VCOT-07-01-0008","article-title":"Force plate gait analysis at the walk and trot in dogs with low-grade hindlimb lameness","volume":"20","author":"Voss","year":"2007","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Br\u00f8nniche M\u00f8ller Nielsen, M., Pedersen, T., Mouritzen, A., Vitger, A.D., Nielsen, L.N., Poulsen, H.H., and Miles, J.E. (2020). Kinetic gait analysis in healthy dogs and dogs with osteoarthritis: An evaluation of precision and overlap performance of a pressure-sensitive walkway and the use of symmetry indices. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0243819"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1055\/s-0038-1632773","article-title":"Gait evaluation in hip osteoarthritic and normal dogs using a serial force plate system","volume":"16","author":"Kennedy","year":"2003","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13028-015-0158-3","article-title":"Gait analysis in dogs with pelvic fractures treated conservatively using a pressure-sensing walkway","volume":"57","author":"Vassalo","year":"2015","journal-title":"Acta Vet. Scand."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1002\/jor.23191","article-title":"Hyaluronic acid versus saline intra-articular injections for amelioration of chronic knee osteoarthritis: A canine model","volume":"34","author":"Pashuck","year":"2016","journal-title":"J. Orthop. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.rvsc.2012.11.020","article-title":"Effects of intraarticular treatment with stanozolol on synovial membrane and cartilage in an ovine model of osteoarthritis","volume":"94","author":"Spadari","year":"2013","journal-title":"Res. Vet. Sci."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/1\/128\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:44:20Z","timestamp":1760132660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/1\/128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,29]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["ani14010128"],"URL":"https:\/\/doi.org\/10.3390\/ani14010128","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,29]]}}}