{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:47:11Z","timestamp":1777092431535,"version":"3.51.4"},"reference-count":418,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"National Funds through FCT\u2014Foundation for Science and Technology","doi-asserted-by":"publisher","award":["CECAV UIDB\/00772\/2020"],"award-info":[{"award-number":["CECAV UIDB\/00772\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"National Funds through FCT\u2014Foundation for Science and Technology","doi-asserted-by":"publisher","award":["MED UIDB\/05183\/2020"],"award-info":[{"award-number":["MED UIDB\/05183\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"National Funds through FCT\u2014Foundation for Science and Technology","doi-asserted-by":"publisher","award":["CHANGE"],"award-info":[{"award-number":["CHANGE"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"National Funds through FCT\u2014Foundation for Science and Technology","doi-asserted-by":"publisher","award":["UI\/BD\/150834\/2021"],"award-info":[{"award-number":["UI\/BD\/150834\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Colostrum contains macro- and micronutrients necessary to meet the nutritional and energy requirements of the neonatal calf, bioactive components that intervene in several physiological aspects, and cells and microorganisms that modulate the calf\u2019s immune system and gut microbiome. Colostrum is sometimes mistaken as transition milk, which, although more nutritive than whole milk, has a distinct biochemical composition. Furthermore, most research about colostrum quality and colostrum management focuses on the transfer of maternal IgG to the newborn calf. The remaining components of colostrum and transition milk have not received the same attention, despite their importance to the newborn animal. In this narrative review, a large body of literature on the components of bovine colostrum was reviewed. The variability of these components was summarized, emphasizing specific components that warrant deeper exploration. In addition, the effects of each component present in colostrum and transition milk on several key physiological aspects of the newborn calf are discussed.<\/jats:p>","DOI":"10.3390\/ani14071130","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T06:04:58Z","timestamp":1712556298000},"page":"1130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["A Comprehensive Review of Bovine Colostrum Components and Selected Aspects Regarding Their Impact on Neonatal Calf Physiology"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4218-498X","authenticated-orcid":false,"given":"Fl\u00e1vio G.","family":"Silva","sequence":"first","affiliation":[{"name":"Veterinary and Animal Research Centre (CECAV), Associate Laboratory of Animal and Veterinary Science (AL4AnimalS), University of Tr\u00e1s-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"},{"name":"MED\u2014Mediterranean Institute for Agriculture, Environment and Development & CHANGE\u2014Global Change and Sustainability Institute, Department of Zootechnics, School of Science and Technology, University of \u00c9vora, P\u00f3lo da Mitra Apartado 94, 7006-554 \u00c9vora, Portugal"},{"name":"Center for Research and Development in Agrifood Systems and Sustainability, Polytechnic Institute of Viana do Castelo, Agrarian School of Ponte de Lima, Rua D. Mendo Afonso, 147 Ref\u00f3ios do Lima, 4990-706 Ponte de Lima, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-2075","authenticated-orcid":false,"given":"Severiano R.","family":"Silva","sequence":"additional","affiliation":[{"name":"Veterinary and Animal Research Centre (CECAV), Associate Laboratory of Animal and Veterinary Science (AL4AnimalS), University of Tr\u00e1s-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9430-9399","authenticated-orcid":false,"given":"Alfredo M. F.","family":"Pereira","sequence":"additional","affiliation":[{"name":"MED\u2014Mediterranean Institute for Agriculture, Environment and Development & CHANGE\u2014Global Change and Sustainability Institute, Department of Zootechnics, School of Science and Technology, University of \u00c9vora, P\u00f3lo da Mitra Apartado 94, 7006-554 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0022-2749","authenticated-orcid":false,"given":"Joaquim Lima","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Veterinary and Animal Research Centre (CECAV), Associate Laboratory of Animal and Veterinary Science (AL4AnimalS), University of Tr\u00e1s-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"},{"name":"Center for Research and Development in Agrifood Systems and Sustainability, Polytechnic Institute of Viana do Castelo, Agrarian School of Ponte de Lima, Rua D. Mendo Afonso, 147 Ref\u00f3ios do Lima, 4990-706 Ponte de Lima, Portugal"}]},{"given":"Cristina","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"MED\u2014Mediterranean Institute for Agriculture, Environment and Development & CHANGE\u2014Global Change and Sustainability Institute, Department of Zootechnics, School of Science and Technology, University of \u00c9vora, P\u00f3lo da Mitra Apartado 94, 7006-554 \u00c9vora, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.3168\/jds.2020-20114","article-title":"Invited review: The importance of colostrum in the newborn dairy calf","volume":"105","author":"Lopez","year":"2022","journal-title":"J. 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