{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T21:57:04Z","timestamp":1774303024488,"version":"3.50.1"},"reference-count":128,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"FCT","doi-asserted-by":"publisher","award":["UIDB\/00276\/2024"],"award-info":[{"award-number":["UIDB\/00276\/2024"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT","doi-asserted-by":"publisher","award":["HORIZON-MSCA-2022-10112045"],"award-info":[{"award-number":["HORIZON-MSCA-2022-10112045"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CryoStore","award":["UIDB\/00276\/2024"],"award-info":[{"award-number":["UIDB\/00276\/2024"]}]},{"name":"CryoStore","award":["HORIZON-MSCA-2022-10112045"],"award-info":[{"award-number":["HORIZON-MSCA-2022-10112045"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>In the last decades, major changes in ecosystems related to industrial development and environmental modifications have had a direct impact on mammalian fertility, as well as on biodiversity. It is widely demonstrated that all these changes impair reproductive function. Several studies have connected the increase of reactive oxygen species (ROS) generated in mitochondria to the recently identified decline of fertility due to various factors, including heat stress. The study of antioxidants, and especially of mitochondria targeted antioxidants, has been focused on identifying more efficient and less toxic therapies that could circumvent fertility problems. These antioxidants can be derived from natural compounds in the diet and delivered to the mitochondria in more effective forms, providing a much more natural therapy. The use of mitochondriotropic diet-based antioxidants in assisted reproductive technologies (ART) may be an important way to overcome low fertility, allowing the conservation of animal biodiversity and productivity. This paper provides a concise review of the current state of the art on this topic, with a particular focus on the antioxidants mitoquinone, AntiOxBEN2, AntiOxCIN4, urolithin A and piperine, and their effects on bovine and other animal species.<\/jats:p>","DOI":"10.3390\/ani15030289","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T05:47:42Z","timestamp":1737438462000},"page":"289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Assisted Reproduction Technologies (ART): Impact of Mitochondrial (Dys)function and Antioxidant Therapy"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5385-4012","authenticated-orcid":false,"given":"Filipa C.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Unit of Biotechnology and Genetic Resources, National Institute of Agrarian and Veterinary Research, Quinta da Fonte Boa, 2005-424 Vale de Santar\u00e9m, Portugal"},{"name":"GeoBioTec\u2014Faculty of Sciences and Technology, New University of Lisbon, Campus da Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0834-5698","authenticated-orcid":false,"given":"Jos\u00e9","family":"Teixeira","sequence":"additional","affiliation":[{"name":"CNC\u2014Centre for Neurosciences and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"CIBB, Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal"}]},{"given":"Fernando","family":"Lidon","sequence":"additional","affiliation":[{"name":"GeoBioTec\u2014Faculty of Sciences and Technology, New University of Lisbon, Campus da Caparica, 2829-516 Caparica, Portugal"}]},{"given":"Fernando","family":"Cagide","sequence":"additional","affiliation":[{"name":"CIQ-Department of Chemistry and Biochemistry, Faculty of Science, University of Porto, Campo Alegre, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1050-2402","authenticated-orcid":false,"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"CIQ-Department of Chemistry and Biochemistry, Faculty of Science, University of Porto, Campo Alegre, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7514-6130","authenticated-orcid":false,"given":"Rosa M. L. N.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Unit of Biotechnology and Genetic Resources, National Institute of Agrarian and Veterinary Research, Quinta da Fonte Boa, 2005-424 Vale de Santar\u00e9m, Portugal"},{"name":"CIISA, Faculty of Veterinary Medicine, University of Lisbon, and Associated Laboratory for Animal and Veterinary Science (AL4AnimalS), Av. da Universidade T\u00e9cnica, 1300-477 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"ref_1","unstructured":"Luoma, J. (2005, January Late). Challenged Conceptions: Environmental Chemicals and Fertility. Proceedings of the Understanding Environmental Contaminants and Human Fertility: Science and Strategy, Menlo Park, CA, USA."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Canipari, R., De Santis, L., and Cecconi, S. (2020). Female Fertility and Environmental Pollution. Int. J. Environ. Res. Public. 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