{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:59:32Z","timestamp":1775141972135,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Statins could increase the effectiveness of Helicobacter pylori eradication therapies due to their anti-inflammatory effect. The aim of this study was to analyze the impact of this therapeutic association in real life. This is a multicenter, prospective, non-interventional study aimed at evaluating the management of H. pylori by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap from 2013 to 2020. The association between statin use and H. pylori eradication effectiveness was evaluated through multivariate analysis. Overall, 9988 and 705 patients received empirical and culture-guided treatment, respectively. Overall, statin use was associated with higher effectiveness in the empirical group (OR = 1.3; 95%CI = 1.1\u20131.5), but no association was found with first-line treatment effectiveness (N = 7738); as an exception, statin use was specifically associated with lower effectiveness of standard triple therapy (OR = 0.76; 95%CI = 0.59\u20130.99). In the rescue therapy empirical group (N = 2228), statins were associated with higher overall effectiveness (OR = 1.9; 95%CI = 1.4\u20132.6). However, sub-analyses by treatment schemes only confirmed this association for the single-capsule bismuth quadruple therapy (OR = 2.8; 95%CI = 1.3\u20135.7). No consistent association was found between statin use and H. pylori therapy effectiveness. Therefore, the addition of statins to the usual H. pylori treatment cannot be currently recommended to improve cure rates.<\/jats:p>","DOI":"10.3390\/antibiotics10080965","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T08:35:52Z","timestamp":1628670952000},"page":"965","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5017-9913","authenticated-orcid":false,"given":"Mar\u00eda","family":"Caldas","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Gastroenterology Unit, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP), Hospital Universitario de La Princesa, Universidad Aut\u00f3noma de Madrid (UAM), 28006 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2974-1382","authenticated-orcid":false,"given":"\u00c1ngeles","family":"P\u00e9rez-Aisa","sequence":"additional","affiliation":[{"name":"Digestive Unit, Hospital Costa del Sol and Red de Investigaci\u00f3n en Servicios de Salud en Enfermedades Cr\u00f3nicas (REDISSEC), 29651 Marbella, Spain"}]},{"given":"Bojan","family":"Tepes","sequence":"additional","affiliation":[{"name":"AM DC Rogaska, 3250 Rogaska Slatina, Slovenia"}]},{"given":"Alma","family":"Keco-Huerga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital de Valme, 41014 Sevilla, Spain"}]},{"given":"Luis","family":"Bujanda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Department of Gastroenterology, Hospital Donostia\/Instituto Biodonostia, Universidad del Pa\u00eds Vasco (UPV\/EHU), 20014 San Sebasti\u00e1n, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-1072","authenticated-orcid":false,"given":"Alfredo","family":"Lucendo","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP), Department of Gastroenterology, Hospital General de Tomelloso, 13700 Ciudad Real, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1717-9345","authenticated-orcid":false,"given":"Luis","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}]},{"given":"Dino","family":"Vaira","sequence":"additional","affiliation":[{"name":"S. Orsola Malpighi Hospital, 40138 Bologna, Italy"}]},{"given":"Luis","family":"Fern\u00e1ndez-Salazar","sequence":"additional","affiliation":[{"name":"Digestive Service, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain"}]},{"given":"Jose","family":"Huguet","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, Spain"}]},{"given":"Jorge","family":"P\u00e9rez-Lasala","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, University Hospital of Torrej\u00f3n, 28850 Madrid, Spain"}]},{"given":"Natasa","family":"Jurecic","sequence":"additional","affiliation":[{"name":"Diagnosticni Center Bled d.o.o., 4260 Bled, Slovenia"}]},{"given":"Galina","family":"Fadeenko","sequence":"additional","affiliation":[{"name":"Digestive Ukrainian Academy of Medical Sciences, 01030 Kyiv, 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Italy"}]},{"given":"Marcis","family":"Leja","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center, GASTRO, Institute of Clinical and Preventive Medicine and Faculty of Medicine, University of Latvia, LV-1079 Riga, Latvia"}]},{"given":"Javier","family":"Molina-Infante","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital San Pedro de Alc\u00e1ntara, 10003 C\u00e1ceres and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), 28006 Madrid, Spain"}]},{"given":"Pavel","family":"Bogomolov","sequence":"additional","affiliation":[{"name":"Universal Clinic Private Medical Center, 129110 Moscow, Russia"}]},{"given":"Sergey","family":"Alekseenko","sequence":"additional","affiliation":[{"name":"Far Eastern State Medical University, 680000 Khabarovsk, Russia"}]},{"given":"Manuel","family":"Dom\u00ednguez-Cajal","sequence":"additional","affiliation":[{"name":"Digestive Service, Hospital San 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Spain"}]},{"given":"Aiman","family":"Sarsenbaeva","sequence":"additional","affiliation":[{"name":"Gastroenterologist Department of Regional Clinical Hospital \u21163, 454076 Chelyabinsk, Russia"}]},{"given":"Pedro","family":"Almela","sequence":"additional","affiliation":[{"name":"Digestive Service, Hospital Universitari General de Castell\u00f3, 12004 Castell\u00f3n, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1296-3803","authenticated-orcid":false,"given":"Perminder","family":"Phull","sequence":"additional","affiliation":[{"name":"Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1658-2178","authenticated-orcid":false,"given":"Marta","family":"Espada","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Gastroenterology Unit, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP), Hospital Universitario de La Princesa, Universidad 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